The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2.

scientific article published on May 2015

The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.3414
P932PMC publication ID4484424
P698PubMed publication ID25890497
P5875ResearchGate publication ID275156255

P50authorBelinda DuchêneQ53225077
Nicolas JonckheereQ53225113
Isabelle Van SeuningenQ58158912
Romain VasseurQ87147072
P2093author name stringAudrey Vincent
Nicolas Skrypek
P2860cites workGlobal cancer statisticsQ22241238
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ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 lossQ33878879
Cancer biomarkers: can we turn recent failures into success?Q34176379
The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathwaysQ34185812
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ABC multidrug transporters: structure, function and role in chemoresistance.Q34586418
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Pharmacogenetic pathway analysis of irinotecanQ37381224
Signal integration by JNK and p38 MAPK pathways in cancer developmentQ37560607
The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family.Q37605606
Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cellsQ38311644
Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabineQ38948274
p53 status determines the role of autophagy in pancreatic tumour developmentQ39048945
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United StatesQ39190004
Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis.Q39226379
Trastuzumab has opposing effects on SN-38-induced double-strand breaks and cytotoxicity in HER2-positive gastric cancer cells depending on administration sequence.Q39610962
Role of efflux pump activity in lapatinib/caelyx combination in breast cancer cell linesQ39799826
The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38.Q39836423
Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environmentQ39847370
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclQ40093939
Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha.Q40220702
Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.Q40464000
The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cellsQ40492838
ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases.Q40577436
Expression of multidrug resistance-associated protein 2 in human gallbladder carcinomaQ41444935
Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.Q41927415
Sorafenib overcomes irinotecan resistance in colorectal cancer by inhibiting the ABCG2 drug-efflux pump.Q45736203
HER2 overexpression correlates with survival after curative resection of pancreatic cancer.Q46016285
Differences in transcript levels of ABC transporters between pancreatic adenocarcinoma and nonneoplastic tissues.Q46476988
A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis.Q47376029
Constitutive Expression of MAP Kinase Phosphatase-1 Confers Multi-drug Resistance in Human Glioblastoma Cells.Q48325028
Of autophagy and in vivo pancreatic carcinogenesis: the p53 status matters!Q53235695
Pancreatic CancerQ54135367
Copy number of chromosome 17 but not HER2 amplification predicts clinical outcome of patients with pancreatic ductal adenocarcinomaQ81073375
Breast cancer resistance protein expression is associated with early recurrence and decreased survival in resectable pancreatic cancer patientsQ83502693
ABCC2 (MRP2, cMOAT) localized in the nuclear envelope of breast carcinoma cells correlates with poor clinical outcomeQ85071186
P4510describes a project that usesImageQuantQ112270642
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectmultiple drug resistanceQ643839
pancreatic cancerQ212961
P304page(s)10853-10867
P577publication date2015-05-01
P1433published inOncotargetQ1573155
P1476titleThe oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2
P478volume6

Reverse relations

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