Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

scientific article published on 3 November 2011

Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1242/DMM.008409
P932PMC publication ID3291643
P698PubMed publication ID22052944
P5875ResearchGate publication ID51769756

P50authorShinya YamanakaQ80917
Erja KerkeläQ39399909
Jari HyttinenQ47236912
P2093author name stringKimmo Kontula
Katriina Aalto-Setälä
Heikki Swan
Olli Silvennoinen
Bruce R Conklin
Anna L Lahti
Ari-Pekka Koivisto
Hugh Chapman
Mari Pekkanen-Mattila
Ville J Kujala
P2860cites workA molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndromeQ24316980
Induced pluripotent stem cell lines derived from human somatic cellsQ27860597
Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
The genetic basis of long QT and short QT syndromes: a mutation updateQ28262724
Modelling the long QT syndrome with induced pluripotent stem cellsQ29620092
Patient-specific induced pluripotent stem-cell models for long-QT syndromeQ29620353
Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndromeQ30499663
Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias.Q33146000
Drug-induced prolongation of the QT intervalQ33151147
Clinical practice. Long-QT syndromeQ33155879
High prevalence of four long QT syndrome founder mutations in the Finnish populationQ33401777
A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cellsQ33564271
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndromeQ33910479
The long QT syndromes: genetic basis and clinical implicationsQ33970623
Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutationQ34793218
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug developmentQ35095735
Long QT syndrome: reduced repolarization reserve and the genetic linkQ36335258
Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspectiveQ37171823
The hERG potassium channel and hERG screening for drug-induced torsades de pointesQ37212382
Post-mortem review and genetic analysis of sudden unexpected death in epilepsy (SUDEP) cases.Q37793374
Cardiomyocyte differentiation of human induced pluripotent stem cellsQ39794134
Generation and characterization of functional cardiomyocytes using induced pluripotent stem cells derived from human fibroblastsQ39803924
Baseline values and sotalol-induced changes of ventricular repolarization duration, heterogeneity, and instability in patients with a history of drug-induced torsades de pointesQ39860280
Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cellsQ40648427
Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG-encoded potassium channel.Q41819839
Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointesQ44331873
Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relativesQ46455168
In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytesQ46569292
Four potassium channel mutations account for 73% of the genetic spectrum underlying long-QT syndrome (LQTS) and provide evidence for a strong founder effect in FinlandQ47398470
Postmortem long QT syndrome genetic testing for sudden unexplained death in the youngQ48480320
Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivationQ48933322
Induced pluripotent stem cell technology for the study of human disease.Q51919490
Sinus node function and ventricular repolarization during exercise stress test in long QT syndrome patients with KvLQT1 and HERG potassium channel defects.Q54095734
Low penetrance in the long-QT syndrome: clinical impactQ77932863
Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndromeQ79352873
Isolation and characterization of I(Kr) in cardiac myocytes by Cs+ permeationQ81356187
Molecular characterization of two founder mutations causing long QT syndrome and identification of compound heterozygous patientsQ83928276
The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cellsQ84250613
P4510describes a project that usesUTA.00112.hFFQ54992201
UTA.00514.LQT2Q54992206
UTA.00525.LQT2Q54992207
UTA.01006.WTQ54992208
UTA.04602.WTQ54992209
P433issue2
P921main subjectlong QT syndromeQ653924
cell lineQ21014462
P304page(s)220-230
P577publication date2011-11-03
P1433published inDisease Models & MechanismsQ1524006
P1476titleModel for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture
P478volume5

Reverse relations

described by source (P1343)
Q54992201UTA.00112.hFF
Q54992206UTA.00514.LQT2
Q54992207UTA.00525.LQT2
Q54992208UTA.01006.WT
Q54992209UTA.04602.WT

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