Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells.

scientific article published on November 1995

Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID1869534
P698PubMed publication ID7485411

P2093author name stringJ M Anderson
A K McNally
P2860cites workSynovial fluid macrophages and blood monocytes differ in their response to IL-4.Q44983424
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IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-gammaQ45309262
Regulation of murine macrophage function by IL-4: IL-4 and IFN-gamma differentially regulate macrophage tumoricidal activation.Q46014288
Theoretical analysis on cell size distribution and kinetics of foreign-body giant cell formation in vivo on polyurethane elastomersQ47408722
IL-4 suppresses cytokine gene expression induced by IFN-gamma and/or IL-2 in murine peritoneal macrophagesQ68053384
Anti-class II MHC antibody induces multinucleated giant cell formation from peripheral blood monocytesQ68065955
IL-3 and granulocyte-macrophage colony-stimulating factor stimulate two distinct phases of adhesion in human monocytesQ68090812
Multinucleate foreign-body giant cell formationQ68161439
Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4Q68340490
IL-4 decreases Fc gamma R membrane expression and Fc gamma R-mediated cytotoxic activity of human monocytesQ68415018
Comparison of the effects of IL-3, granulocyte-macrophage colony-stimulating factor, and macrophage colony-stimulating factor in supporting monocyte differentiation in culture. Analysis of macrophage antibody-dependent cellular cytotoxicityQ68421976
IL-4 inhibits superoxide production by human mononuclear phagocytesQ68447056
IL-4 inhibits the expression of IL-8 from stimulated human monocytesQ68533598
IL-4 down-regulates IL-1 and TNF gene expression in human monocytesQ69738307
Foreign-body giant cells and polyurethane biostability: in vivo correlation of cell adhesion and surface crackingQ70199511
Formation of giant cells in vivoQ70401677
Direct evidence that inflammatory multinucleate giant cells form by fusionQ70405659
Differential regulation of formation of multinucleated giant cells from concanavalin A-stimulated human blood monocytes by IFN-gamma and IL-4Q70615420
Role for interleukin-4 in foreign-body giant cell formation on a poly(etherurethane urea) in vivoQ70890044
Intracellular levels and stimulated release of lysosomal enzymes from human peripheral blood monocytes and monocyte-derived macrophagesQ72863013
Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cellsQ22066161
Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritisQ28580456
Induction of Multinucleated Giant Cell Formation from In Vitro Culture of Human Monocytes with Interleukin-3 and Interferon-γ: Comparison with Other Stimulating FactorsQ30442848
Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2Q33858688
Secretory products of macrophagesQ34557411
Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4Q35604825
Multinucleated giant cells generated in vitro. Terminally differentiated macrophages with down-regulated c-fms expressionQ35818196
Complement C3 participation in monocyte adhesion to different surfacesQ35834513
Transformation of monocytes in tissue culture into macrophages, epithelioid cells, and multinucleated giant cells. An electron microscope studyQ36187790
Recombinant human gamma-interferon induces human monocyte polykaryon formationQ36273638
1 alpha,25-dihydroxyvitamin D3 promotes fusion of mouse alveolar macrophages both by a direct mechanism and by a spleen cell-mediated indirect mechanismQ37348815
Interleukin-4: a prototypic immunoregulatory lymphokineQ37699523
Inflammatory giant cellsQ40334272
Lymphokine production by human T cells in disease statesQ40661109
Inflammatory response to implantsQ41428788
The separation, long-term cultivation, and maturation of the human monocyteQ41842963
Inhibition of human monocyte adhesion by interleukin-4Q42464430
Cytokine-induced generation of multinucleated giant cells in vitro requires interferon-gamma and expression of LFA-1.Q43812503
Effects of recombinant human colony stimulating factors (CSF) (granulocyte-macrophage CSF, granulocyte CSF, and CSF-1) on human monocyte/macrophage differentiationQ44419796
Administration of recombinant IL-4 to humans regulates gene expression, phenotype, and function in circulating monocytesQ44697590
IL-4 inhibits macrophage-mediated killing of Plasmodium falciparum in vitro. A possible parasite-immune evasion mechanismQ44762307
Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicansQ44907215
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
giant cellQ2152526
P304page(s)1487-1499
P577publication date1995-11-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleInterleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells
P478volume147

Reverse relations

cites work (P2860)
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