Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis

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Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.20041785
P932PMC publication ID2212837
P698PubMed publication ID15753204
P5875ResearchGate publication ID7981428

P50authorRamses ForsythQ73149661
R Maarten EgelerQ89698733
Nicola AnnelsQ115203377
P2093author name stringPancras C W Hogendoorn
Claudia M J M Faaij
Cristiana E T da Costa
P2860cites workFlt3+ macrophage precursors commit sequentially to osteoclasts, dendritic cells and microgliaQ24794597
Bone resorption by osteoclastsQ28145169
Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identificationQ28280533
Integrin receptor-mediated mobilisation of intranuclear calcium in rat osteoclastsQ28568502
Treatment of Langerhans cell histiocytosis with pamidronateQ31983931
Multinucleated giant cell formation induced by IFN-gamma/IL-3 is associated with restriction of virulent Mycobacterium tuberculosis cell to cell invasion in human monocyte monolayersQ32012327
Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67Q33528106
Multinucleated giant cellsQ33802348
Mechanisms of bisphosphonate effects on osteoclasts, tumor cell growth, and metastasisQ35057815
Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells.Q35795586
Multinucleated giant cells generated in vitro. Terminally differentiated macrophages with down-regulated c-fms expressionQ35818196
The histopathology of Langerhans cell histiocytosisQ36291266
Aberrant chemokine receptor expression and chemokine production by Langerhans cells underlies the pathogenesis of Langerhans cell histiocytosis.Q42944753
Expression of cell cycle-related gene products in Langerhans cell histiocytosis.Q44240570
Roles of macrophage-colony stimulating factor and osteoclast differentiation factor in osteoclastogenesis.Q54046308
Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase.Q54083199
Long-lived immature dendritic cells mediated by TRANCE-RANK interactionQ56966224
Langerhans cell histiocytosisQ71870918
Expression of adhesion molecules in Langerhans' cell histiocytosisQ72093953
Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorptionQ72648485
Multinucleated giant cells generation induced by interferon-gamma. Changes in the expression and distribution of the intercellular adhesion molecule-1 during macrophages fusion and multinucleated giant cell formationQ72823082
Differential In situ cytokine profiles of Langerhans-like cells and T cells in Langerhans cell histiocytosis: abundant expression of cytokines relevant to disease and treatmentQ73254123
Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expressionQ73271328
Langerhans cell histiocytosis: an evaluation of histopathological parameters, demonstration of proliferation by Ki-67 and mitotic bodiesQ73320953
Dendritic cells generated from CD34+ progenitor cells with flt3 ligand, c-kit ligand, GM-CSF, IL-4, and TNF-alpha are functional antigen-presenting cells resembling mature monocyte-derived dendritic cellsQ73475202
Distinct subsets of dendritic cells resembling dermal DCs can be generated in vitro from monocytes, in the presence of different serum supplementsQ73661037
Proinflammatory cytokine (TNFalpha/IL-1alpha) induction of human osteoclast formationQ74802758
Interferon-alpha and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cellsQ77303042
Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by the rheumatoid arthritis microenvironmentQ80445625
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectgiant cellQ2152526
Langerhans cell histiocytosis specific to childhoodQ55786740
P304page(s)687-693
P577publication date2005-03-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titlePresence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis
P478volume201

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