RNA therapeutics targeting osteoclast-mediated excessive bone resorption

scientific article published on 10 September 2011

RNA therapeutics targeting osteoclast-mediated excessive bone resorption is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.ADDR.2011.09.002
P932PMC publication ID3293106
P698PubMed publication ID21945356
P5875ResearchGate publication ID51672444

P2093author name stringYuwei Wang
David W Grainger
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Osteoclast precursors, RANKL/RANK, and immunologyQ36324916
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Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alphaQ28593804
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The structural era of endocytosisQ33683033
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beta(3) Integrin subunit mediates the bone-resorbing function exerted by cultured myeloma plasma cellsQ43298697
Setting characteristics and mechanical behaviour of a calcium phosphate bone cement containing tetracycline.Q43580609
Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signalingQ43648531
New insights into the regulation of cathepsin K gene expression by osteoprotegerin ligandQ43667822
Alendronate reduces periprosthetic bone loss after uncemented primary total hip arthroplasty: a prospective randomized studyQ43791673
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Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue.Q43987361
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Effect of alendronate on periprosthetic bone loss after cemented primary total hip arthroplasty: a prospective randomized studyQ44709291
Regulation of the type 1 inositol 1,4,5-trisphosphate receptor by phosphorylation at tyrosine 353.Q44755165
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Adenoviral delivery of osteoprotegerin ameliorates bone resorption in a mouse ovariectomy model of osteoporosisQ44920044
Inhibition of the osteoclast V-ATPase by small interfering RNAsQ81098185
Drugs for prevention and treatment of postmenopausal osteoporosisQ81246923
Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitorsQ81489492
Long-term safety of bisphosphonatesQ81502820
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptorsQ81772313
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Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNAQ37219628
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiationQ37286240
Osteoporosis: how long should we treat?Q37312945
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivoQ37346696
A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivoQ37366963
Bone health - An investmentQ37388070
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Physiological levels of calcitonin regulate the mouse osteoclast calcitonin receptor by a protein kinase Alpha-mediated mechanismQ38287550
Microarray profile of gene expression during osteoclast differentiation in modelled microgravity.Q38341566
Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulatorQ38363724
Skeletal repair by in situ formation of the mineral phase of boneQ38505425
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Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaqueQ39362979
Gefitinib inhibits the ability of human bone marrow stromal cells to induce osteoclast differentiation: implications for the pathogenesis and treatment of bone metastasisQ39365959
Retinoblastoma protein-interacting zinc finger 1 (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expressionQ39711113
Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesisQ39714931
Synthesis and physical and physiological properties of 4'-thioRNA: application to post-modification of RNA aptamer toward NF-kappaBQ39752190
The role of Mac-1 (CD11b/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-kappaB ligandQ39942676
Silencing of YY1 downregulates RIZ1 promoter in human osteosarcoma.Q39980827
AP-1 stimulates the cathepsin K promoter in RAW 264.7 cellsQ40075875
RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathwayQ40118270
Sialylation of cell surface glycoconjugates is essential for osteoclastogenesisQ40130750
Targeted deletion of the osteoclast protein-tyrosine phosphatase (PTP-oc) promoter prevents RANKL-mediated osteoclastic differentiation of RAW264.7 cells.Q40133607
Morphological features of osteoclasts derived from a co-culture system.Q40231635
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis.Q40264908
RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesisQ40271536
Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritisQ40437124
TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSF.Q40542323
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The signaling adapter protein DAP12 regulates multinucleation during osteoclast developmentQ40589041
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Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammationQ40832683
Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signalingQ40890957
RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis.Q41107411
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Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivoQ41753607
Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclastsQ42043704
Defective osteoclastogenesis by IKKbeta-null precursors is a result of receptor activator of NF-kappaB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiationQ42426515
Intracellular ClC-3 chloride channels promote bone resorption in vitro through organelle acidification in mouse osteoclastsQ42524180
Cell-to-Cell adhesion via intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 pathway is involved in 1alpha,25(OH)2D3, PTH and IL-1alpha-induced osteoclast differentiation and bone resorptionQ42527337
Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity.Q51947476
Suppression of osteoclastogenesis by N,N-dimethyl-D-erythro-sphingosine: a sphingosine kinase inhibition-independent action.Q51985828
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The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts.Q52509359
Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification.Q52537176
A microtubule-binding myosin required for nuclear anchoring and spindle assembly.Q52560093
Coordination of microtubules and the actin cytoskeleton is important in osteoclast function, but calcitonin disrupts sealing zones without affecting microtubule networks.Q52571447
MDM2 antagonist Nutlin-3 suppresses the proliferation and differentiation of human pre-osteoclasts through a p53-dependent pathway.Q52580047
Application of small interfering RNA for inhibition of lipopolysaccharide-induced osteoclast formation and cytokine stimulation.Q53481036
Chemical modification of siRNAs to improve serum stability without loss of efficacy.Q53600125
Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis.Q53672361
Optimized transfection of diced siRNA into mature primary human osteoclasts: inhibition of cathepsin K mediated bone resorption by siRNA.Q54644666
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Regulation of Actin Ring Formation by Rho GTPases in OsteoclastsQ57372361
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanismsQ58326878
Genetic control of skeletal developmentQ58326890
TRAIL inhibits osteoclastic differentiation by counteracting RANKL-dependent p27Kip1 accumulation in pre-osteoclast precursorsQ59225103
WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorptionQ61053891
BisphosphonatesQ61786757
Phosphorylation of a Wiscott-Aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorptionQ64377259
Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow culturesQ68274092
Bone-targeted carbonic anhydrase inhibitors: effect of a proinhibitor on bone resorption in vitroQ69244135
Targeted delivery of antineoplastic agent to bone: biodistribution studies of technetium-99m-labeled gem-bisphosphonate conjugate of methotrexateQ70845000
Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritisQ71503443
Direct stimulation of bone resorption by epidermal growth factorQ72075897
Biochemical characterization of human osteoclast integrins. Osteoclasts express alpha v beta 3, alpha 2 beta 1, and alpha v beta 1 integrinsQ72865482
Particle opsonization and lung macrophage cytokine response. In vitro and in vivo analysisQ72901016
Osteoclast differentiation is associated with transient upregulation of cyclin-dependent kinase inhibitors p21(WAF1/CIP1) and p27(KIP1)Q73339269
Transforming growth factor-beta1 incorporated during setting in calcium phosphate cement stimulates bone cell differentiation in vitroQ73379018
Elimination and biochemical responses to intravenous alendronate in postmenopausal osteoporosisQ73794664
Effects of added antibiotics on the basic properties of anti-washout-type fast-setting calcium phosphate cementQ74148811
Targeting systemically administered proteins to bone by bisphosphonate conjugationQ74251618
In vitro elution of gentamicin, amikacin, and ceftiofur from polymethylmethacrylate and hydroxyapatite cementQ74351252
Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal womenQ74586981
Involvement of lymphocyte function-associated antigen-1 and intercellular adhesion molecule-1 in osteoclastogenesis: a possible role in direct interaction between osteoclast precursorsQ77180427
RNA interference targeting Fas protects mice from fulminant hepatitisQ78961966
Osteoclastic differentiation and function regulated by old and new pathwaysQ79370827
Three Na+/Ca2+ exchanger (NCX) variants are expressed in mouse osteoclasts and mediate calcium transport during bone resorptionQ79818794
Expression of mouse osteoclast K-Cl Co-transporter-1 and its role during bone resorptionQ79822562
A transmembrane osteoclastic protein-tyrosine phosphatase regulates osteoclast activity in part by promoting osteoclast survival through c-Src-dependent activation of NFkappaB and JNK2Q80074246
The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritisQ80337310
Percutaneous injection of recombinant human bone morphogenetic protein-2 in a calcium phosphate paste accelerates healing of a canine tibial osteotomyQ80337437
The in vitro antibiotic release from anti-washout apatite cement using chitosanQ80528155
Phenotypic non-equivalence of murine (monocyte-) macrophage cells in biomaterial and inflammatory modelsQ80928315
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)1341-1357
P577publication date2011-09-10
P1433published inAdvanced Drug Delivery ReviewsQ2825362
P1476titleRNA therapeutics targeting osteoclast-mediated excessive bone resorption
P478volume64

Reverse relations

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