Genetic control of skeletal development

article

Genetic control of skeletal development is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0959-437X(00)00228-8
P698PubMed publication ID11532394

P50authorErwin F. WagnerQ40012298
P2093author name stringG Karsenty
P2860cites workAtp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification.Q52537176
Fosl1 is a transcriptional target of c-Fos during osteoclast differentiationQ57675158
Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1Q57675161
Mice deficient in Abl are osteoporotic and have defects in osteoblast maturationQ58085524
c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodelingQ58326943
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γQ59064307
Characterization of Osf1, an osteoblast-specific transcription factor binding to a critical cis-acting element in the mouse Osteocalcin promotersQ73066690
The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutantsQ73531419
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis 1Q22306225
Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasiaQ24309601
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cellsQ24315251
RANK is essential for osteoclast and lymph node developmentQ24598872
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formationQ24600279
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationQ24603266
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytesQ24628843
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone developmentQ28119185
TGF-beta signalling from cell membrane to nucleus through SMAD proteinsQ28131770
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand familiesQ28137631
Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinaseQ28137640
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding proteinQ28137935
Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosisQ28140437
Negative regulation of BMP/Smad signaling by Tob in osteoblastsQ28143428
Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosisQ28143618
Bone resorption by osteoclastsQ28145169
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and manQ28201425
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiationQ28240596
Bone: formation by autoinductionQ28251545
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related proteinQ28281538
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone massQ28505908
PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growthQ28506149
Maturational disturbance of chondrocytes in Cbfa1-deficient miceQ28506259
Regulation of chondrocyte differentiation by Cbfa1Q28509820
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
Sox9 is required for cartilage formationQ28588649
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide geneQ28590408
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblastsQ29547605
Proposed standard nomenclature for new tumor necrosis factor family members involved in the regulation of bone resorption. The American Society for Bone and Mineral Research President's Committee on NomenclatureQ30621126
FGFs, heparan sulfate and FGFRs: complex interactions essential for developmentQ33828280
Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis.Q33916614
Regulation of the differentiation and function of osteoclastsQ34010151
The osteoblast: a sophisticated fibroblast under central surveillanceQ34021172
AP-1 in mouse development and tumorigenesisQ34279346
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitroQ34459310
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient miceQ35076965
Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bonesQ36316526
Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptorsQ36375584
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerinQ39116155
Chondrogenesis just ain't what it used to be.Q39906724
Fra-1 replaces c-Fos-dependent functions in miceQ40445308
Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.Q41121255
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.Q41649459
Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytesQ42934690
Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia.Q45345530
P433issue5
P304page(s)527-532
P577publication date2001-10-01
P1433published inCurrent Opinion in Genetics & DevelopmentQ13505684
P1476titleGenetic control of skeletal development
P478volume11

Reverse relations

cites work (P2860)
Q394896403β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species
Q35586731A bit of give and take: the relationship between the extracellular matrix and the developing chondrocyte
Q36323606A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation
Q38322094A specific oligodeoxynucleotide promotes the differentiation of osteoblasts via ERK and p38 MAPK pathways
Q37374302ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae
Q39041957Achondroplasia: Development, pathogenesis, and therapy.
Q42210499Adult stem cells properties in terms of commitment, aging and biological safety of grit-blasted and Acid-etched ti dental implants surfaces
Q42549696Aggrecan is required for growth plate cytoarchitecture and differentiation
Q42931803Aggrecan modulation of growth plate morphogenesis
Q35138548Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos
Q35007314Aryl hydrocarbon receptors in osteoclast lineage cells are a negative regulator of bone mass
Q36324476Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes
Q42003155Bone morphogenetic protein receptor in the osteogenic differentiation of rat bone marrow stromal cells
Q81659680Cbfa1-dependent expression of an interferon-inducible p204 protein is required for chondrocyte differentiation
Q39793750Cellular morphology and markers of cartilage and bone in the marine teleost Sparus auratus.
Q47330729Connexin43 intercellular communication drives the early differentiation of human bone marrow stromal cells into osteoblasts
Q37286240Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation
Q38188554Current understanding on the molecular basis of chondrogenesis
Q91643125Daily intake of polyamine-rich Saccharomyces cerevisiae S631 prevents osteoclastic activation and bone loss in ovariectomized mice
Q36612109Defining structural abnormalities of the hip joint at risk of degeneration
Q101468030Defining the Critical Period of Hedgehog Pathway Inhibitor-Induced Cranial Base Dysplasia in Mice
Q42552589Disruption of calvarial ossification in E2f4 mutant embryos correlates with increased proliferation and progenitor cell populations
Q28588130Dlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification
Q55230047EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation.
Q38847179Effects of electromagnetic fields on osteoporosis: A systematic literature review
Q50448979Emodin regulates bone remodeling by inhibiting osteoclastogenesis and stimulating osteoblast formation.
Q40450496Eriodicyol inhibits osteoclast differentiation and ovariectomy-induced bone loss in vivo.
Q88071349Extracellular matrix dynamics during mesenchymal stem cells differentiation
Q36111408FGF signaling in the developing endochondral skeleton
Q28505595FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate
Q39260911Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.
Q28235267Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development
Q34874767Formation and function of the ruffled border in osteoclasts
Q34963037Functions of AP1 (Fos/Jun) in bone development
Q37730952Functions of nuclear factor kappaB in bone
Q47425056Genome scan for QTLs underlying bone size variation at 10 refined skeletal sites: genetic heterogeneity and the significance of phenotype refinement
Q35802390Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis
Q28539657Growth factor priming differentially modulates components of the extracellular matrix proteome in chondrocytes and synovium-derived stem cells
Q30579948Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors
Q38944254High glucose inhibits receptor activator of nuclear factor‑κB ligand-induced osteoclast differentiation via downregulation of v‑ATPase V0 subunit d2 and dendritic cell‑specific transmembrane protein
Q37348836Host cell specificity of minute virus of mice in the developing mouse embryo
Q41640132Icariside II promotes osteogenic differentiation of bone marrow stromal cells in beagle canine
Q46931406Identification of vitamin D receptor as a target of p63.
Q28593802Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base
Q29618116Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
Q37401772Inhibition of osteoblastic bone formation by nuclear factor-kappaB.
Q42680295Integrated mRNA and microRNA transcriptome analyses reveal regulation of thermal acclimation in Gymnocypris przewalskii: A case study in Tibetan Schizothoracine fish.
Q35575324MAP kinases in chondrocyte differentiation.
Q38641208Mandible and Tongue Development
Q34994492Mechanisms of bone resorption and new bone formation in spondyloarthropathies
Q36073894Mechanistic insight into osteoclast differentiation in osteoimmunology
Q34246045Mice Deficient in NF-κB p50 and p52 or RANK Have Defective Growth Plate Formation and Post-natal Dwarfism.
Q34695969Myocyte enhancer factor-2 interacting transcriptional repressor (MITR) is a switch that promotes osteogenesis and inhibits adipogenesis of mesenchymal stem cells by inactivating peroxisome proliferator-activated receptor gamma-2.
Q37516656NOTCHing the bone: insights into multi-functionality.
Q37177999Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification.
Q38285398Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies
Q42823527Osteoblast-specific expression of MEF induces osteopenia through downregulation of osteoblastogenesis and upregulation of osteoclastogenesis
Q30482448Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis
Q29547556Osteoclast differentiation and activation
Q36803600Osteosarcoma development and stem cell differentiation
Q51614047Ovariectomy-associated changes in bone mineral density and bone marrow haematopoiesis in rats.
Q35191578PPAR Gamma Activity and Control of Bone Mass in Skeletal Unloading
Q37161420Perichondrial expression of Wdr5 regulates chondrocyte proliferation and differentiation
Q38163881Polyamine delivery as a tool to modulate stem cell differentiation in skeletal tissue engineering
Q34792780Primitive adult hematopoietic stem cells can function as osteoblast precursors
Q38824534Protective effects of casein-derived peptide VLPVPQK against hydrogen peroxide-induced dysfunction and cellular oxidative damage in rat osteoblastic cells
Q57675150RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β
Q24629421RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro
Q35800463RNA therapeutics targeting osteoclast-mediated excessive bone resorption
Q34611297Reaching a genetic and molecular understanding of skeletal development
Q33527391Regulation of gene expression by PI3K in mouse growth plate chondrocytes
Q38103811Regulatory mechanisms for the development of growth plate cartilage
Q36794857Relationship between joint shape and the development of osteoarthritis
Q42828127Retinoic acid inhibits osteogenic differentiation of mouse embryonic palate mesenchymal cells
Q40598895RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation.
Q33933027Role of ox-PAPCs in the differentiation of mesenchymal stem cells (MSCs) and Runx2 and PPARγ2 expression in MSCs-like of osteoporotic patients
Q38056632Roles of Wnt signals in bone resorption during physiological and pathological states.
Q34731222Signaling crosstalk between RANKL and interferons in osteoclast differentiation
Q35553533Signalling in osteoclasts and the role of Fos/AP1 proteins
Q33299652Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation
Q33327777The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation
Q35831159The regulation of osteoclast differentiation by Wnt signals
Q33861355The synergistic regulatory effect of Runx2 and MEF transcription factors on osteoblast differentiation markers
Q34191657The two faces of serotonin in bone biology
Q28512237Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis
Q83177173Vascular endothelial growth factor-D activates VEGFR-3 expressed in osteoblasts inducing their differentiation
Q93014287Vaspin antagonizes high fat-induced bone loss in rats and promotes osteoblastic differentiation in primary rat osteoblasts through Smad-Runx2 signaling pathway
Q35083564Wdr5 is required for chick skeletal development.
Q34156626Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB.

Search more.