Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites

scientific article published on 13 March 2007

Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites is …
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scholarly articleQ13442814

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P356DOI10.1093/NAR/GKM090
P932PMC publication ID1874654
P698PubMed publication ID17355985
P5875ResearchGate publication ID6451177

P50authorStephen C StromQ40919746
P2093author name stringScott S Auerbach
Curtis J Omiecinski
Matthew A Stoner
Stephanie M Zamule
P2860cites workAndrostane metabolites bind to and deactivate the nuclear receptor CAR-betaQ22003994
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The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CARQ24554260
Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B geneQ24554439
Multiple sequence alignment with the Clustal series of programsQ24672842
Alternatively spliced isoforms of the human constitutive androstane receptorQ24679627
Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptorQ24797407
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 geneQ28137778
Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbitalQ28190299
The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4Q28201907
Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional stateQ28205269
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genesQ28213013
Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1Q28360604
At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cellsQ29618360
Nuclear receptors and lipid physiology: opening the X-filesQ29619362
Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).Q33781766
DNA binding of the glucocorticoid receptor is not essential for survivalQ34469789
Induction of phase I, II and III drug metabolism/transport by xenobioticsQ36099291
Separation of retinoid X receptor homo- and heterodimerization functionsQ36139646
The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers.Q38312085
Overexpressed activated retinoid X receptors can mediate growth inhibitory effects of retinoids in human carcinoma cellsQ38332852
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Serine 202 regulates the nuclear translocation of constitutive active/androstane receptorQ40336237
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The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated tQ40901938
Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase geneQ41237260
Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cellsQ42526349
Transactivation via RAR/RXR-Sp1 interaction: characterization of binding between Sp1 and GC box motifQ43752382
Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivoQ43986663
Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptorQ44535717
Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 CellsQ44628543
Expression of constitutive androstane receptor splice variants in human tissues and their functional consequencesQ44934633
A structural basis for constitutive activity in the human CAR/RXRalpha heterodimerQ45195405
The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoterQ46513221
Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alphaQ46955937
Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes.Q51727651
Neural network prediction of translation initiation sites in eukaryotes: perspectives for EST and genome analysis.Q52282359
An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte culturesQ73599278
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)2177-2190
P577publication date2007-03-13
P1433published inNucleic Acids ResearchQ135122
P1476titleTransactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites
P478volume35