Transgenic Production of an Anti HIV Antibody in the Barley Endosperm

scientific article published on 13 October 2015

Transgenic Production of an Anti HIV Antibody in the Barley Endosperm is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1040476H
P356DOI10.1371/JOURNAL.PONE.0140476
P8608Fatcat IDrelease_63rtgf3wc5d5ja4vx3xikbabrq
P932PMC publication ID4604167
P698PubMed publication ID26461955
P5875ResearchGate publication ID282972677

P50authorMarkus SackQ55475826
Elsa ArcalisQ56942086
Jochen KumlehnQ38799428
Goetz HenselQ42258810
Twan RuttenQ42258823
P2093author name stringEva Stoger
Stanislav Melnik
Friedrich Altmann
Udo Conrad
Doreen M Floss
P2860cites workA role for gamma 3 hordein in the transport and targeting of prolamin polypeptides to the vacuole of developing barley endospermQ48096150
Unexpected deposition patterns of recombinant proteins in post-endoplasmic reticulum compartments of wheat endospermQ48167880
Biochemical and functional characterization of anti-HIV antibody-ELP fusion proteins from transgenic plants.Q51790897
Evidence of two enzymes performing the de-N-glycosylation of proteins in barley: expression during germination, localization within the grain and set-up during grain formation.Q52165919
Improving the protein content and composition of cereal grainQ56094870
High-value products from transgenic maizeQ57522847
Molecular pharming in cereal cropsQ57522980
A plant-derived recombinant human glucocerebrosidase enzyme--a preclinical and phase I investigationQ21092136
Protein disulfide isomeraseQ28263008
Analysis of immunoglobulin glycosylation by LC-ESI-MS of glycopeptides and oligosaccharidesQ28288481
Rapid transient production in plants by replicating and non-replicating vectors yields high quality functional anti-HIV antibodyQ28476129
A DNA transformation-competent Arabidopsis genomic library in Agrobacterium.Q30988477
Nutrient requirements of suspension cultures of soybean root cellsQ34237145
Rapid high-level production of functional HIV broadly neutralizing monoclonal antibodies in transient plant expression systemsQ34637663
Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic Arabidopsis seeds.Q35611679
Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants.Q37233850
Production of antibodies in plants: status after twenty yearsQ37687534
Transgene expression systems in the Triticeae cerealsQ37782471
Barley grains for the production of endotoxin-free growth factorsQ38121252
Efficient generation of transgenic barley: the way forward to modulate plant-microbe interactions.Q40168807
From gene to harvest: insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plantsQ40692385
Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants.Q40766118
Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12.Q41111458
Evidence for a novel route of wheat storage proteins to vacuolesQ42028404
The elimination of a selectable marker gene in the doubled haploid progeny of co-transformed barley plants.Q42424753
The changing fate of a secretory glycoprotein in developing maize endospermQ43101037
Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibodyQ43723507
Genetic transformation of barley (Hordeum vulgare L.) via infection of androgenetic pollen cultures with Agrobacterium tumefaciensQ44468884
Plant species and organ influence the structure and subcellular localization of recombinant glycoproteinsQ45021927
Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structureQ46697395
Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans.Q46916838
A novel cis-acting element, ESP, contributes to high-level endosperm-specific expression in an oat globulin promoterQ48085263
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectbarleyQ61665121
P304page(s)e0140476
P577publication date2015-10-13
P1433published inPLOS OneQ564954
P1476titleTransgenic Production of an Anti HIV Antibody in the Barley Endosperm
P478volume10

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cites work (P2860)
Q38796221Edible plants for oral delivery of biopharmaceuticals.
Q89612908Expression of Single Chain Variable Fragment (scFv) Molecules in Plants: A Comprehensive Update
Q40219487Heritable Genomic Fragment Deletions and Small Indels in the Putative ENGase Gene Induced by CRISPR/Cas9 in Barley
Q58754253Microscopic and Proteomic Analysis of Dissected Developing Barley Endosperm Layers Reveals the Starchy Endosperm as Prominent Storage Tissue for ER-Derived Hordeins Alongside the Accumulation of Barley Protein Disulfide Isomerase (HvPDIL1-1)
Q50299878Nanobody-Directed Specific Degradation of Proteins by the 26S-Proteasome in Plants
Q42696866Seed-Specific Expression of Spider Silk Protein Multimers Causes Long-Term Stability

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