Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

scientific article published on March 2000

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0002-9440(10)64963-2
P932PMC publication ID1876840
P698PubMed publication ID10702411
P5875ResearchGate publication ID25615938

P2093author name stringD Moechars
F Van Leuven
J Van Dorpe
C Van den Haute
K Spittaels
I Tesseur
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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset familiesQ27860677
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Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral ischaemia in the ratQ28569838
Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowthQ28771743
Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of femalesQ33563135
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell lineQ33848287
Specific regional transcription of apolipoprotein E in human brain neuronsQ35745315
Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's diseaseQ35754598
Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.Q35846021
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Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemiaQ56268222
Phosphorylation of tau protein is not affected in mice lacking apolipoprotein EQ58216318
Regulation of Thy-1 gene expression in transgenic miceQ69902613
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Phosphorylation of tau in apolipoprotein E-deficient miceQ70958117
A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 alleleQ71265364
A closely linked gene to apolipoprotein E may serve as an additional risk factor for Alzheimer's diseaseQ71587380
Targeted inactivation of the mouse alpha 2-macroglobulin geneQ71707001
ApoE genotype and survival from intracerebral haemorrhageQ72020086
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Effect of apolipoprotein E on neurite outgrowth and beta-amyloid-induced toxicity in developing rat primary hippocampal culturesQ72996400
Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediatedQ73507862
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A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic.Q40965861
A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteinsQ41056322
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Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related proteinQ41150323
The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerizationQ41308477
Tau and ubiquitin immunoreactivity at different stages of formation of Alzheimer neurofibrillary tanglesQ41598172
Reactive astrocytes: cellular and molecular cues to biological functionQ41673434
PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic modelQ41699855
Thy-1, the enigmatic extrovert on the neuronal surfaceQ42111935
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Age-related phosphorylation and fragmentation events influence the distribution profiles of distinct tau isoforms in mouse brain.Q45946084
Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenesQ46156203
Increased apolipoprotein E mRNA in the hippocampus in Alzheimer disease and in rats after entorhinal cortex lesioningQ46163083
The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variantQ46323718
Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's diseaseQ47700813
Regionally specific neuronal expression of human APOE gene in transgenic miceQ47972600
A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.Q48041239
Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controlsQ48092219
Expression of Thy-1/lacZ fusion genes in the CNS of transgenic miceQ48097010
GFAP promoter directs astrocyte-specific expression in transgenic miceQ48163933
The -491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEepsilon4 allele and Alzheimer's diseaseQ48230376
Site-specific dephosphorylation of tau of apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatmentQ48307898
Intraneuronal ApoE in human visual cortical areas reflects the staging of Alzheimer disease pathologyQ48323914
The mouse Thy-1.2 glycoprotein gene: complete sequence and identification of an unusual promoterQ48368454
Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.Q48477194
Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenesQ48603343
Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortexQ48636064
Apolipoprotein E ∈4 Associated With Chronic Traumatic Brain Injury in BoxingQ48659275
Cytoskeletal changes in the brains of mice lacking calcineurin A alphaQ48754848
A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicityQ48864142
Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: implications for Alzheimer's diseaseQ49082479
Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos.Q49087978
Abeta-peptide length and apolipoprotein E genotype in Alzheimer's diseaseQ49106878
Cystatin C and apolipoprotein E immunoreactivities in CA1 neurons in ischemic gerbil hippocampusQ49114133
Preliminary report of a genetic basis for cognitive decline after cardiac operations. The Neurologic Outcome Research Group of the Duke Heart Center.Q52041566
Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease.Q52050809
Expression of X-linked genes in androgenetic, gynogenetic, and normal mouse preimplantation embryos.Q52211093
Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injuryQ53200531
Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease.Q53204218
Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region.Q53206202
Induction of apolipoprotein E mRNA in the hippocampus of the gerbil after transient global ischemia.Q53212645
ApoE synthesis in human neuroblastoma cells.Q53220957
A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease.Q53221276
Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice.Q53222443
Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.Q53314304
Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele.Q53315213
Distortion of allelic expression of apolipoprotein E in Alzheimer's disease.Q53327233
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)951-964
P577publication date2000-03-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleExpression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice
P478volume156

Reverse relations

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