Apolipoprotein E: From lipid transport to neurobiology

scientific article published on September 18, 2010

Apolipoprotein E: From lipid transport to neurobiology is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.PLIPRES.2010.09.001
P953full work available at URLhttps://europepmc.org/articles/pmc3022415?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20854843/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20854843/?tool=EBI
https://europepmc.org/articles/PMC3022415
https://europepmc.org/articles/PMC3022415?pdf=render
https://doi.org/10.1016/j.plipres.2010.09.001
https://api.elsevier.com/content/article/PII:S0163782710000470?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0163782710000470?httpAccept=text/plain
P932PMC publication ID3022415
P698PubMed publication ID20854843
P5875ResearchGate publication ID46380361

P50authorRobert O. RyanQ57668754
Vasanthy NarayanaswamiQ95983970
P2093author name stringPaul S. Hauser
P2860cites workCholesterol binds to synaptophysin and is required for biogenesis of synaptic vesiclesQ22011017
Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's diseaseQ22248091
Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregationQ24291128
Behavior of human apolipoprotein E in aqueous solutions and at interfacesQ24300390
Absence of central cholinergic deficits in ApoE knockout miceQ48664853
Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioningQ48668350
Human apolipoprotein E4 accelerates beta-amyloid deposition in APPsw transgenic mouse brainQ48744526
Severe learning deficits in apolipoprotein E-knockout mice in a water maze task.Q48759623
Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob diseaseQ48795523
Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease.Q48799582
A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicityQ48864142
The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP miceQ48890273
Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathologyQ49087363
Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemiaQ49144756
Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: the allele E3 is neuroprotective whereas E4 increases fatalitiesQ49160372
Comparison of Lipid-Binding and Lecithin:Cholesterol Acyltransferase Activation of the Amino- and Carboxyl-Terminal Domains of Human Apolipoprotein E3Q49167558
A monomeric, biologically active, full-length human apolipoprotein E.Q50928824
Regulation of central nervous system cholesterol homeostasis by the liver X receptor agonist TO-901317.Q51795695
Apolipoprotein E knockout mice display procedural deficits in the Morris water maze: analysis of learning strategies in three versions of the task.Q52010630
Gene dose of the epsilon 4 allele of apolipoprotein E and disease progression in sporadic late-onset Alzheimer's disease.Q52016466
Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice.Q52051272
Cell surface receptor binding of phospholipid . protein complexes containing different ratios of receptor-active and -inactive E apoprotein.Q52760145
No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice.Q53235325
Reversal of presynaptic deficits of apolipoprotein E-deficient mice in human apolipoprotein E transgenic mice.Q53235329
Association of apolipoprotein E polymorphism with outcome after head injury.Q53777504
Lipid binding-induced conformational changes in the N-terminal domain of human apolipoprotein E.Q53940110
ApoE as a prognostic factor for post–traumatic comaQ58451995
Apolipoprotein E polymorphism and atherosclerosisQ68126635
Heterogeneity of human plasma very low density lipoproteins. Separation of species differing in protein componentsQ68654109
Regulation of apolipoprotein E gene expression after injury of the rat sciatic nerveQ68740798
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteinsQ68921833
Association of apolipoprotein E with the low density lipoprotein receptor: demonstration of its co-operativity on lipid microemulsion particlesQ69679704
The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragmentsQ70169929
The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of bindingQ70169933
Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformationQ70213695
Human apolipoprotein E. The complete amino acid sequenceQ70312109
Genetic control of human apolipoprotein E polymorphism: comparison of one- and two-dimensional techniques of isoprotein analysisQ70427868
Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactionsQ70478363
The locus for apolipoprotein E (apoE) is linked to the complement component C3 (C3) locus on chromosome 19 in manQ70587571
Apolipoprotein E: binding to soluble Alzheimer's beta-amyloidQ70687889
Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoformsQ70875567
Characterization of a unique human apolipoprotein E variant associated with type III hyperlipoproteinemiaQ71133200
Reutilization of cholesterol-1,2-H3 in the regeneration of peripheral nerve. An autoradiographic studyQ71484430
Type III hyperlipoproteinemia associated with apolipoprotein E deficiencyQ71576154
Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloidQ72167723
Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modificationQ72885840
Apolipoprotein E expression by neurons surviving excitotoxic stressQ73277918
Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in cultureQ73491113
Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediatedQ73507862
Role of lipoproteins in the delivery of lipids to axons during axonal regenerationQ73919813
The lipid-associated conformation of the low density lipoprotein receptor binding domain of human apolipoprotein EQ74037597
The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brainQ74290658
Lipid binding-induced conformational change in human apolipoprotein E. Evidence for two lipid-bound states on spherical particlesQ74453728
The low density lipoprotein receptor active conformation of apolipoprotein E. Helix organization in n-terminal domain-phospholipid disc particlesQ77332976
Pathogenesis of cerebral amyloid angiopathyQ79196249
Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic studyQ24319783
Apolipoprotein E receptors in the nervous systemQ24607165
The LDL receptorQ24658039
Structure of the LDL receptor extracellular domain at endosomal pHQ27640067
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein EQ27663468
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoformsQ27730887
Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemiaQ27733293
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset familiesQ27860677
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeuticsQ27860914
Alzheimer's disease: the cholesterol connectionQ28186482
Conformational parameters for amino acids in helical, beta-sheet, and random coil regions calculated from proteinsQ28240446
Prediction of protein conformationQ28240456
Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single siteQ28264429
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's diseaseQ28265290
Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloidQ28279517
Apolipoprotein E: cholesterol transport protein with expanding role in cell biologyQ28294791
LXRS and FXR: the yin and yang of cholesterol and fat metabolismQ28295718
Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein EQ28508278
Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-IQ28565847
Uptake of lipoproteins for axonal growth of sympathetic neuronsQ28578928
Isoform-specific binding of apolipoprotein E to beta-amyloidQ28596589
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's diseaseQ29614952
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene deliveryQ29615235
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein EQ29615236
A receptor-mediated pathway for cholesterol homeostasisQ29616158
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse modelQ29617937
Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in miceQ30486146
Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E.Q31452265
Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic miceQ31735508
Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous systemQ33262322
Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyondQ33702396
Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's diseaseQ33732191
An optimized negative-staining protocol of electron microscopy for apoE4 POPC lipoproteinQ33784574
Molecular basis of exchangeable apolipoprotein functionQ33796767
Greasing the wheels of Abeta clearance in Alzheimer's disease: the role of lipids and apolipoprotein E.Q37497056
Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approachesQ37623844
Amphipathic helix motif: classes and propertiesQ37987535
The carbohydrate content of apoliprotein E from human very low density lipoproteinsQ39579630
Apolipoprotein E polymorphism in health and diseaseQ39756689
Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feedingQ39941350
Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblastsQ39984968
Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteinsQ40099596
Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblastsQ40224633
Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegenerationQ40349274
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.Q40528558
Relation of high-density lipoprotein subfractions and apolipoprotein E isoforms to coronary disease.Q40564186
Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transferQ40571686
Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's diseaseQ40621541
Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction.Q40662233
The role of apolipoprotein E in the nervous system.Q40679942
Apolipoprotein E: structure-function relationshipsQ40737965
Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotypeQ40817463
Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's diseaseQ40849918
Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptidesQ40879124
Apolipoprotein E secretion by macrophages: its potential physiological functions.Q41235061
Human apolipoprotein E: the Alzheimer's disease connection.Q41239700
Amyloid beta-peptide is produced by cultured cells during normal metabolismQ41602809
Differential neurotrophic effects of apolipoprotein E in aged transgenic miceQ41664893
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.Q41671941
Carboxyl-terminal domain of human apolipoprotein E: expression, purification, and crystallization.Q41699828
Effect of arginine 172 on the binding of apolipoprotein E to the low density lipoprotein receptorQ41715714
Conformational reorganization of the four-helix bundle of human apolipoprotein E in binding to phospholipidQ41734798
Apolipoprotein E: phospholipid binding studies with synthetic peptides containing the putative receptor binding regionQ42034886
Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic miceQ42045406
Contributions of the carboxyl-terminal helical segment to the self-association and lipoprotein preferences of human apolipoprotein E3 and E4 isoformsQ42173744
Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injuryQ42456741
Apolipoprotein E-deficient mice are not more susceptible to the biochemical and memory deficits induced by nucleus basalis lesionQ42483912
A unified scheme for initiation and conformational adaptation of human apolipoprotein E N-terminal domain upon lipoprotein binding and for receptor binding activityQ42615768
A monomeric human apolipoprotein E carboxyl-terminal domainQ42625731
The epidermal growth factor homology domain of the LDL receptor drives lipoprotein release through an allosteric mechanism involving H190, H562, and H586.Q42749068
Orientation and mode of lipid-binding interaction of human apolipoprotein E C-terminal domainQ42816401
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.Q43138847
Pyrene fluorescence analysis offers new insights into the conformation of the lipoprotein-binding domain of human apolipoprotein E.Q43194660
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brainQ43243545
Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout miceQ43581885
Essential role for cholesterol in synaptic plasticity and neuronal degenerationQ43693049
CNS synaptogenesis promoted by glia-derived cholesterolQ43794738
Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humansQ43811092
Cholesterol's role in synapse formationQ43929699
Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cellsQ43931362
APOE polymorphism and clinical duration determine regional neuropathology in Swedish APP(670, 671) mutation carriers: implications for late-onset Alzheimer's disease.Q43982514
NMR structure and dynamics of a receptor-active apolipoprotein E peptideQ44010486
Glycosylation of human apolipoprotein E. The carbohydrate attachment site is threonine 194.Q44028113
Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease.Q44189963
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.Q44251907
Effect of domain interaction on apolipoprotein E levels in mouse brain.Q44267254
Lipid binding ability of human apolipoprotein E N-terminal domain isoforms: correlation with protein stability?Q44368466
Domain structure and lipid interaction in human apolipoproteins A-I and E, a general modelQ44412885
Lipid-bound Structure of an Apolipoprotein E-derived PeptideQ44412891
Effects of polymorphism on the lipid interaction of human apolipoprotein E.Q44548874
Inter-molecular coiled-coil formation in human apolipoprotein E C-terminal domainQ44659103
Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particlesQ44739118
A two-module region of the low-density lipoprotein receptor sufficient for formation of complexes with apolipoprotein E ligandsQ44742662
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.Q44795511
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.Q44989710
Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitroQ45081026
Examination of lipid-bound conformation of apolipoprotein E4 by pyrene excimer fluorescenceQ45263580
Lipid-induced extension of apolipoprotein E helix 4 correlates with low density lipoprotein receptor binding ability.Q45930842
Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE.Q46001228
Interaction with amyloid beta peptide compromises the lipid binding function of apolipoprotein E.Q46067044
Human apolipoprotein E. Receptor binding activity of truncated variants with carboxyl-terminal deletionsQ46118074
Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domainQ46175909
Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrilsQ46212443
Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levelsQ46262337
Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutionsQ46398183
Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domainsQ46421943
Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerizationQ46474280
Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuronQ46505506
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.Q46529938
Age-related congophilic inclusions in the brains of apolipoprotein E-deficient mice.Q46585768
Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.Q46620615
Apolipoprotein E*dipalmitoylphosphatidylcholine particles are ellipsoidal in solutionQ46629889
Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteinsQ46656933
Structural analysis of lipoprotein E particlesQ46698144
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.Q46738144
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer diseaseQ46738145
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 miceQ46738149
Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.Q46740358
Adult mouse astrocytes degrade amyloid-beta in vitro and in situQ46779933
Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholineQ46797037
Is Alzheimer's disease an apolipoprotein E amyloidosis?Q46974350
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptidesQ47349499
Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouseQ48024701
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivoQ48087583
Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic miceQ48095820
Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patientsQ48146785
The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's diseaseQ48254282
Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult ratsQ48256982
Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variantQ48390455
Synthesis, intracellular processing, and signal peptide of human apolipoprotein EQ48390623
Testing times for the "amyloid cascade hypothesis".Q48430429
ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakageQ48461941
Liver X receptor activation restores memory in aged AD mice without reducing amyloidQ48487098
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide depositionQ48601482
Lipoproteins in the central nervous systemQ33922696
Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivoQ33998681
Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-proteinQ33998693
Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative miceQ34142722
Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategiesQ34160761
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic miceQ34175241
Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology regionQ34180927
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.Q34194714
Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wallQ34198863
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicityQ34210006
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic targetQ34210015
Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantationQ34225777
Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3Q34229659
Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluidsQ34255552
Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptorsQ34263181
Abnormal in vivo metabolism of apolipoprotein E4 in humansQ34539465
Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous systemQ34559847
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer diseaseQ34662682
Alzheimer disease therapy: can the amyloid cascade be halted?Q34828328
Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor familyQ35023109
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's diseaseQ35084110
Genetics of the apolipoprotein E system in manQ35203817
The low-density lipoprotein receptor: ligands, debates and loreQ35607734
Specific regional transcription of apolipoprotein E in human brain neuronsQ35745315
Alzheimer disease: mechanistic understanding predicts novel therapiesQ35750804
Cerebral lipid deposition in aged apolipoprotein-E-deficient miceQ35764103
Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null miceQ35765799
Clearing amyloid through the blood-brain barrierQ35771708
Novel action of apolipoprotein E (ApoE): ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neuronsQ35808508
Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic miceQ35809803
Role for glia in synaptogenesisQ35836047
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptorsQ35839729
Progress toward identification of protease activity involved in proteolysis of apolipoprotein e in human brainQ35864607
Clearance of Alzheimer's Abeta peptide: the many roads to perdition.Q35875785
ApoE deficiency compromises the blood brain barrier especially after injury.Q35944147
Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's diseaseQ36003498
The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and functionQ36031499
The LDL receptor: how acid pulls the triggerQ36160311
Fine structural localization of cholesterol-1,2- 3 H in degenerating and regenerating mouse sciatic nerveQ36193872
Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in cultureQ36255422
Cholesterol and apoe: a target for Alzheimer's disease therapeuticsQ36304886
Cholesterol in Alzheimer's diseaseQ36317585
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.Q36383616
Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal diseaseQ36412999
Nucleotide sequence and structure of the human apolipoprotein E geneQ36423417
Apolipoprotein E structure: insights into function.Q36527194
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer diseaseQ36604545
LRP in amyloid-beta production and metabolismQ36690854
Genetic influences on outcome following traumatic brain injuryQ36753393
Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemiaQ36857781
Apolipoprotein E and cholesterol in aging and disease in the brainQ37009967
Molecular studies of pH-dependent ligand interactions with the low-density lipoprotein receptorQ37071794
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neuronsQ37117670
Insight on the molecular envelope of lipid-bound apolipoprotein E from electron paramagnetic resonance spectroscopy.Q37149489
Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structureQ37307244
Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cellsQ37337782
The role of calcium in lipoprotein release by the low-density lipoprotein receptorQ37357958
Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte functionQ37447983
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectneurobiologyQ2728012
lipid metabolismQ2792936
P304page(s)62-74
P577publication date2010-09-18
P1433published inProgress in Lipid ResearchQ15757018
P1476titleApolipoprotein E: from lipid transport to neurobiology
Apolipoprotein E: From lipid transport to neurobiology
P478volume50

Reverse relations

cites work (P2860)
Q30402554A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain-domain interactions
Q37501686A novel estrogen-regulated avian apolipoprotein
Q42016650A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.
Q28085213APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective
Q36451896APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.
Q35064519Acrolein modification impairs key functional features of rat apolipoprotein E: identification of modified sites by mass spectrometry
Q50420659Age-Related Changes in the Behavior of Apolipoprotein E Knockout Mice.
Q35843108Age-related differences in memory and executive functions in healthy APOE ɛ4 carriers: the contribution of individual differences in prefrontal volumes and systolic blood pressure
Q59357369Aging and Apolipoprotein E in HIV Infection
Q64060113Alzheimer's disease: risk factors and potentially protective measures
Q38543425Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights
Q34616336An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach
Q58803681ApoE Regulates the Development of Adult Newborn Hippocampal Neurons
Q39121388ApoE enhances nanodisk-mediated curcumin delivery to glioblastoma multiforme cells
Q38008109ApoE genotype: from geographic distribution to function and responsiveness to dietary factors
Q41203382ApoE rs429358 and rs7412 Polymorphism and Gender Differences of Serum Lipid Profile and Cognition in Aging Chinese Population
Q46762520ApoE-deficient promotes blood-brain barrier disruption in experimental autoimmune encephalomyelitis via alteration of MMP-9.
Q36602079Apolipoprotein E Regulates Injury-Induced Activation of Hippocampal Neural Stem and Progenitor Cells
Q38407177Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence
Q91779698Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation
Q28249988Apolipoprotein E isoforms and lipoprotein metabolism
Q30413990Apolipoprotein E polymorphisms and severity of cerebral palsy: a cross-sectional study in 255 children in Norway
Q89972211Apolipoprotein E regulates the maturation of injury-induced adult-born hippocampal neurons following traumatic brain injury
Q38197948Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease
Q35222628Apolipoprotein E, carbon dioxide vasoreactivity, and cognition in older adults: effect of hypertension
Q38489344Apolipoprotein E-dependent differences in innate immune responses of maturing human neuroepithelial progenitor cells exposed to HIV-1.
Q30572801Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.
Q38435698Apolipoprotein E4 Suppresses Neuronal-Specific Gene Expression in Maturing Neuronal Progenitor Cells Exposed to HIV.
Q42247507Apolipoprotein e: essential catalyst of the Alzheimer amyloid cascade
Q48873908Apolipoprotein ɛ4 is Associated with Dementia and Cognitive Impairment Predominantly Due to Alzheimer's Disease and Not with Vascular Cognitive Impairment: A Singapore-Based Cohort
Q90310484Association between APOE polymorphisms and lipid profile in Mexican Amerindian population
Q50559366Association of White Matter Integrity and Cognitive Functions in Chinese Non-Demented Elderly with the APOE ɛ4 Allele.
Q47270627Atomistic Insights into Structural Differences between E3 and E4 Isoforms of Apolipoprotein E.
Q50553487Attentional performance, impulsivity, and related neurotransmitter systems in apoE2, apoE3, and apoE4 female transgenic mice.
Q36906438BDNF Genotype Interacts with Motor Function to Influence Rehabilitation Responsiveness Poststroke
Q41854389Biochemical and biophysical characterization of recombinant rat apolipoprotein E: similarities to human apolipoprotein E3.
Q42008541Blocking the apolipoprotein E/amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology
Q30435790Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study
Q36783549Brain-targeted delivery of resveratrol using solid lipid nanoparticles functionalized with apolipoprotein E.
Q90163512Cellular Uptake and Clearance of Oxidatively-modified Apolipoprotein E3 by Cerebral Cortex Endothelial Cells
Q34669455Changes in the proteomic profiles of mouse brain after infection with cyst-forming Toxoplasma gondii
Q90637181Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay
Q52631118Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion.
Q53802856Common variants of APOE are associated with anti-epileptic drugs resistance in Han Chinese patients.
Q35889289Comparative Proteomic Analysis of Two Uveitis Models in Lewis Rats
Q39014590Dietary DHA and health: cognitive function ageing.
Q38075010Drug targeting to brain: a systematic approach to study the factors, parameters and approaches for prediction of permeability of drugs across BBB.
Q30559265Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial
Q47125219Effects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides
Q43085965Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function
Q47584760Efficient creation of an APOE knockout rabbit
Q50972027Elevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene.
Q27306763Embryonic Medaka Model of Microglia in the Developing CNS Allowing In Vivo Analysis of Their Spatiotemporal Recruitment in Response to Irradiation
Q35130903FAX1, a novel membrane protein mediating plastid fatty acid export
Q42005396Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4.
Q42174067Fluorescence study of domain structure and lipid interaction of human apolipoproteins E3 and E4.
Q38007345Functional primate genomics--leveraging the medical potential
Q30371094Gene sequences regulating the production of apoE and cerebral palsy of variable severity.
Q30300651Genes determining the severity of cerebral palsy: the role of single nucleotide polymorphisms on the amount and structure of apolipoprotein E.
Q42323951Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry.
Q57707722How proteomic ApoE serotyping could impact Alzheimer’s disease risk assessment: genetic testing by proteomics
Q36539906Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo
Q39266217Human apolipoprotein e resequencing by proteomic analysis and its application to serotyping.
Q61809971Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan
Q57174487Impact of apolipoprotein E genotypes on vitamin E and memantine treatment outcomes in Alzheimer's disease
Q24567759Impact of apolipoprotein E on Alzheimer's disease
Q50711684Impact of cerebrospinal fluid matrix on the detection of Alzheimer's disease with Aβ42 and influence of disease on the total-Aβ42/Aβ40 ratio.
Q33807188Influence of domain stability on the properties of human apolipoprotein E3 and E4 and mouse apolipoprotein E.
Q38160779Innate immune responses to HIV infection in the central nervous system
Q36988218Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory
Q47098616Interpreting the Mechanism of APOE (p.Leu167del) Mutation in the Incidence of Familial Hypercholesterolemia; An In-silico Approach
Q94502431Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer's Disease
Q36847737Links between copper and cholesterol in Alzheimer's disease
Q57656679Lipidated apolipoprotein E4 structure and its receptor binding mechanism determined by a combined cross-linking coupled to mass spectrometry and molecular dynamics approach
Q36682138Lipoprotein metabolism in nonalcoholic fatty liver disease
Q51748928Long-term effects of low-dose mouse liver irradiation involve ultrastructural and biochemical changes in hepatocytes that depend on lipid metabolism.
Q34412109Longitudinal trajectories of cholesterol from midlife through late life according to apolipoprotein E allele status
Q58567981Meta-Analysis of the Relationship between the Gene and the Onset of Parkinson's Disease Dementia
Q35099780Meta-analysis of peripheral blood apolipoprotein E levels in Alzheimer's disease
Q36865222Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels.
Q51095457Mouse Models of Alzheimer's Disease.
Q36116997Multiple loci influencing hippocampal degeneration identified by genome scan
Q26771804New Drugs from Marine Organisms in Alzheimer's Disease
Q39697118Nonlinear associations between plasma cholesterol levels and neuropsychological function
Q37598119Nonlinear longitudinal trajectories of cholesterol and neuropsychological function
Q38801607Novel susceptibility loci for Alzheimer's disease
Q28582464Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift
Q42704131Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study
Q30410253Pyrene: a probe to study protein conformation and conformational changes.
Q24314295Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2
Q46069993Retracted: Advances in the physiological and pathological implications of cholesterol.
Q56980246Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer's disease
Q38079285Signaling pathways of apoE and its role of gene expression in glomerulus diseases
Q46297739The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D.
Q91733029The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease
Q39516222The genetic contribution to disease risk and variability in response to diet: where is the hidden heritability?
Q34656168The relationship between midlife and late life alcohol consumption, APOE e4 and the decline in learning and memory among older adults
Q34450271The role of apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease is doubtful

Search more.