Impact of cerebrospinal fluid matrix on the detection of Alzheimer's disease with Aβ42 and influence of disease on the total-Aβ42/Aβ40 ratio.

scientific article published in September 2015

Impact of cerebrospinal fluid matrix on the detection of Alzheimer's disease with Aβ42 and influence of disease on the total-Aβ42/Aβ40 ratio. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/JNC.13297
P8608Fatcat IDrelease_ef7lvyzdzvfptcwi57drt42uou
P698PubMed publication ID26332787

P50authorKaj BlennowQ28321550
Henrik ZetterbergQ6252048
Johannes StrefferQ57587710
Marc MerckenQ117234565
J Randall SlemmonQ117234589
P2093author name stringNiels Andreasen
Alice Shapiro
Gary Romano
P2860cites work“Mini-mental state”Q25938989
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's DiseaseQ27860795
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascadeQ29614407
Decreased clearance of CNS beta-amyloid in Alzheimer's diseaseQ29616534
Amyloid precursor protein trafficking, processing, and functionQ29617429
Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous systemQ33262322
Vascular pathology in the aged human brainQ33699436
Cerebrospinal fluid and plasma biomarkers in Alzheimer diseaseQ34098866
Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid β-amyloid 42: a cross-validation study against amyloid positron emission tomographyQ34435040
Apolipoprotein E: From lipid transport to neurobiologyQ34497951
Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric studyQ35669559
Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaintsQ36661066
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkersQ37008887
Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid betaQ37304821
Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structureQ37307244
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectivesQ37769104
Regulated intramembrane proteolysis--lessons from amyloid precursor protein processingQ37854085
Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up studyQ40349700
Development and advanced validation of an optimized method for the quantitation of Aβ42 in human cerebrospinal fluidQ42218996
Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer diseaseQ44282867
Enrichment and analysis of Alzheimer's Abeta1-42 peptide in human plasma and whole blood.Q45972670
CSF biomarkers in Alzheimer's disease and controls: associations with APOE genotype are modified by age.Q46092918
APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42.Q47376522
Aβ1-15/16 as a potential diagnostic marker in neurodegenerative diseasesQ48260033
Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognitionQ48475140
Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology.Q51576488
Correlation of longitudinal cerebrospinal fluid biomarkers with cognitive decline in healthy older adults.Q51723038
Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairment.Q51905659
Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load.Q51924516
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.Q51986028
Differential CSF biomarker levels in APOE-epsilon4-positive and -negative patients with memory impairment.Q52001000
Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.Q53412673
Measurement of Aβ1-42 in cerebrospinal fluid is influenced by matrix effects.Q53430179
No association between the α2-macroglobulin (A2M) deletion and Alzheimer's disease, and no change in A2M mRNA, protein, or protein expressionQ57676222
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
cerebrospinal fluidQ54196
P304page(s)1049-1058
P577publication date2015-09-01
P1433published inJournal of NeurochemistryQ6295643
P1476titleImpact of cerebrospinal fluid matrix on the detection of Alzheimer's disease with Aβ42 and influence of disease on the total-Aβ42/Aβ40 ratio.
P478volume135

Reverse relations

cites work (P2860)
Q51737722Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer's disease dementia in mild cognitive impairment.
Q39451611Amyloid Beta and Tau as Alzheimer's Disease Blood Biomarkers: Promise From New Technologies
Q54943546Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios.
Q37664735BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants
Q39195180Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer's Disease Pathogenesis.
Q93066085Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta
Q33871427Multicenter Analytical Validation of Aβ40 Immunoassays.
Q41097447Plasma Levels of Aβ42 and Tau Identified Probable Alzheimer's Dementia: Findings in Two Cohorts
Q59802837Preanalytical approaches to improve recovery of amyloid-β peptides from CSF as measured by immunological or mass spectrometry-based assays

Search more.