Effects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides

scientific article published on 20 November 2017

Effects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PONE.0188191
P932PMC publication ID5695774
P698PubMed publication ID29155887

P50authorSandra D MulderQ82597817
Sandra VillegasQ37370937
P2093author name stringRobert Veerhuis
Laia Montoliu-Gaya
P2860cites workApolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitroQ24321663
ApoE promotes the proteolytic degradation of AbetaQ24651102
Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neuronsQ27301082
Astrocytes: biology and pathologyQ27490746
Topology of human apolipoprotein E3 uniquely regulates its diverse biological functionsQ27672294
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset familiesQ27860677
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeuticsQ27860914
Apolipoprotein E: far more than a lipid transport proteinQ28204471
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapyQ28282855
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's diseaseQ28504767
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's diseaseQ29614881
Decreased clearance of CNS beta-amyloid in Alzheimer's diseaseQ29616534
Alzheimer's diseaseQ29616743
Two adjacent domains (141-150 and 151-160) of apoE covalently linked to a class A amphipathic helical peptide exhibit opposite atherogenic effects.Q30497594
Binding and uptake of A beta1-42 by primary human astrocytes in vitroQ33390631
Anti-inflammatory and recycling properties of an apolipoprotein mimetic peptide, Ac-hE18A-NH(2)Q33618352
In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathologyQ33995580
Methods for analysis of amyloid-β aggregates.Q34095967
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's diseaseQ34157492
Structure and lipid interactions of an anti-inflammatory and anti-atherogenic 10-residue class G⁎ apolipoprotein J peptide using solution NMRQ34384359
The pathogenesis of senile plaquesQ34421483
Apolipoprotein E: From lipid transport to neurobiologyQ34497951
Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous systemQ34559847
Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's diseaseQ34960461
Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicityQ35608051
Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 MiceQ36065117
Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.Q50747899
Apolipoprotein E and antioxidants have different mechanisms of inhibiting Alzheimer's beta-amyloid fibril formation in vitro.Q52226054
SP-40,40 is a constituent of Alzheimer's amyloidQ53179261
Competition of Abeta amyloid peptide and apolipoprotein E for receptor-mediated endocytosis.Q53226591
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteinsQ68921833
An ApoE-Abeta inhibition complex in Abeta fibril extensionQ71824491
Amyloid associated proteins in Alzheimer's and prion diseaseQ36173056
Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's diseaseQ36424857
Mechanisms of Disease: astrocytes in neurodegenerative diseaseQ36658874
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditionsQ36835522
The effect of apolipoprotein mimetic peptides in inflammatory disorders other than atherosclerosisQ37097367
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's diseaseQ37118356
Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's diseaseQ37217951
Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragmentQ37364347
Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease.Q37364350
The amyloid hypothesis for Alzheimer's disease: a critical reappraisalQ37490185
Apolipoprotein E mimetics and cholesterol-lowering propertiesQ37965590
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothesQ37979641
Inflammation in Alzheimer's Disease and Molecular Genetics: Recent UpdateQ38558744
Complex and differential glial responses in Alzheimer's disease and ageingQ38753519
Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role.Q38904336
Ammonium hydroxide treatment of Aβ produces an aggregate free solution suitable for biophysical and cell culture characterizationQ39418248
Clusterin overexpression and its possible protective role in transthyretin deposition in familial amyloidotic polyneuropathyQ39443274
An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathwayQ39557102
Functional and structural properties of lipid-associated apolipoprotein J (clusterin).Q41815057
The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complexQ42161240
Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendencyQ42846245
Astrocytic A beta 1-42 uptake is determined by A beta-aggregation state and the presence of amyloid-associated proteinsQ43026196
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.Q44132564
An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice.Q46119869
Seeding of A beta fibril formation is inhibited by all three isotypes of apolipoprotein E.Q46722154
Understanding the contribution of disulfide bridges to the folding and misfolding of an anti-Aβ scFvQ48364112
Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease.Q48424552
The role of astrocytes in amyloid β-protein toxicity and clearanceQ48520121
Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumabQ48852013
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e0188191
P577publication date2017-11-20
P1433published inPLOS OneQ564954
P1476titleEffects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides
P478volume12

Reverse relations

Q99414188Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Micecites workP2860

Search more.