Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia

scientific article published on March 1, 1992

Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1992PNAS...89.1750S
P356DOI10.1073/PNAS.89.5.1750
P8608Fatcat IDrelease_q7uoed6bubfxrcvmkm6eg2n6nm
P953full work available at URLhttps://europepmc.org/articles/PMC48530
https://europepmc.org/articles/PMC48530?pdf=render
P932PMC publication ID48530
P698PubMed publication ID1542669
P5875ResearchGate publication ID21612395

P2093author name stringK. Harada
F. Takaku
Y. Yazaki
M. Katsuki
T. Murase
N. Yamada
M. Shimada
H. Shimano
T. Gotoda
C. Fukazawa
P2860cites workSurface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptorQ24297663
Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteinsQ24609758
Apolipoprotein E: cholesterol transport protein with expanding role in cell biologyQ28294791
Hepatic and renal expression of rat apolipoprotein E under control of the metallothionein promoter in transgenic miceQ28565078
A receptor-mediated pathway for cholesterol homeostasisQ29616158
Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbitsQ33832739
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic miceQ34175241
Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptorsQ34263181
Abnormal in vivo metabolism of apolipoprotein E4 in humansQ34539465
Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbitsQ34575925
Complete nucleotide sequence of the gene encoding the rat apolipoprotein EQ35059046
Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbitsQ35577426
Metabolism of apolipoprotein B-100 in large very low density lipoproteins of blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbitsQ35595098
Metabolism of lipoproteins containing apolipoprotein B-100 in blood plasma of rabbits: heterogeneity related to the presence of apolipoprotein E.Q35606300
Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptorQ36299005
Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbitsQ36312775
Rat apolipoprotein E mRNA. Cloning and sequencing of double-stranded cDNAQ36591500
Rate and equilibrium constants for binding of apo-E HDL c (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: Evidence for multiple receptor binding of apo-E HDL cQ37330623
Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unitQ37556999
MetallothioneinQ39740491
The effect of apo E secretion on lipoprotein uptake in transfected cellsQ41656283
Quantitative determination of serum triglycerides by the use of enzymesQ43418524
The enhanced cellular uptake of very-low-density lipoprotein enriched in apolipoprotein EQ44935618
Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma. Impact on receptor binding activityQ46168707
In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic miceQ46251735
Multiple tissue-specific elements control the apolipoprotein E/C-I gene locus in transgenic miceQ46507581
Enhanced metabolism of normolipidemic human plasma very low density lipoprotein in cultured cells by exogenous apolipoprotein E-3Q67967629
Apolipoprotein E polymorphism and atherosclerosisQ68126635
Accumulation of human apolipoprotein E in the plasma of transgenic miceQ68905307
Structure of the low-density lipoprotein receptor-related protein (LRP) promoterQ69404071
Measurement of apolipoprotein B radioactivity in whole blood plasma by precipitation with isopropanolQ69644739
Enzymatic determination of total serum cholesterolQ69744405
Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteinsQ71302410
Serum lipoprotein measurement--liquid chromatography and sequential floatation (ultracentrifugation) comparedQ71703822
Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemiaQ72060994
The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and EQ72868797
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
hypercholesterolemiaQ762713
overexpressionQ61643320
P1104number of pages5
P304page(s)1750-1754
P577publication date1992-03-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleOverexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia
P478volume89

Reverse relations

cites work (P2860)
Q37228000A human apolipoprotein E mimetic peptide reduces atherosclerosis in aged apolipoprotein E null mice
Q39442352A new recombinant human apolipoprotein E mimetic peptide with high-density lipoprotein binding and function enhancing activity
Q33242076ApoE plasma levels and risk of cardiovascular mortality in old age
Q44511121Apolipoprotein E binding to low density lipoprotein receptor-related protein-1 inhibits cell migration via activation of cAMP-dependent protein kinase A.
Q74171232Apolipoprotein E gene expression is reduced in apolipoprotein A-I transgenic mice
Q24318760Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase
Q35919265Apolipoprotein E-induced cell signaling in the vessel wall
Q34497951Apolipoprotein E: From lipid transport to neurobiology
Q44158115Arterial hardening in mice
Q28584877Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age
Q37383956Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.
Q33993678Current, new and future treatments in dyslipidaemia and atherosclerosis
Q33893953Detection of Apolipoprotein E Gene Polymorphism and Blood Lipid Level in Hemodialysis Patients
Q34137756Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice
Q77714412Effect of human apolipoprotein E isoforms on plasma lipids, lipoproteins and apolipoproteins in apolipoprotein E-deficient mice
Q43682775Effects of short-term treatment with corticotropin on the serum apolipoprotein pattern
Q56965460Fetal HDL/apoE: a novel regulator of gene expression in human placental endothelial cells
Q30661436Gene correction of the apolipoprotein (Apo) E2 phenotype to wild-type ApoE3 by in situ chimeraplasty
Q37351939Genes and physiology: molecular physiology in genetically engineered animals
Q54575442Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein.
Q37381203Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.
Q45948223Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.
Q37381987Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma
Q34198863Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall
Q42061995Insight into lipid surface recognition and reversible conformational adaptations of an exchangeable apolipoprotein by multidimensional heteronuclear NMR techniques
Q34141163Intestinal expression of human apolipoprotein A-IV in transgenic mice fails to influence dietary lipid absorption or feeding behavior
Q24563247Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes
Q77452740Lipoproteins and atherogenesis
Q40588222Lipoproteins and their functions
Q35765799Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice
Q40601689Molecular biology and gene transfer in atherosclerosis in the stenting era.
Q35043691Mouse models as tools for dissecting disorders of lipoprotein metabolism
Q46959635Murine mentors: transgenic and knockout models of surgical disease
Q37519955Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.
Q55333947Plasma disturbance of phospholipid metabolism in major depressive disorder by integration of proteomics and metabolomics.
Q41021318Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.
Q36434617Recent developments in the treatment of atherosclerosis
Q42443609Regulation of lipoprotein metabolism by estrogen in inbred strains of mice occurs primarily by posttranscriptional mechanisms
Q71239660Regulation of the apolipoprotein E by dietary lipids occurs by transcriptional and post-transcriptional mechanisms
Q28378715Renal apolipoproteins in nephrotic rats
Q35108120S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease.
Q40336543Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice
Q35974993Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein
Q36559706Testis-specific expression of a metallothionein I-driven transgene correlates with undermethylation of the locus in testicular DNA.
Q41333505The human apolipoprotein E gene is negatively regulated in human liver HepG2 cells by the transcription factor BEF-1.
Q33213990The key role of apolipoprotein E in atherosclerosis
Q71860408Transcriptional regulation of apolipoprotein E expression by cyclic AMP
Q40781025Transgenic animals as models for human disease--report of an EC Study Group
Q36525382Transgenic mouse models of lipoprotein metabolism and atherosclerosis
Q41755840Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis
Q45872976Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by intramuscular injection of plasmid DNA.
Q37288251Triptolide inhibits the progression of atherosclerosis in apolipoprotein E-/- mice
Q33902876Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E.
Q46632174USF1 and dyslipidemias: converging evidence for a functional intronic variant

Search more.