Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice

scientific article

Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCIENCE.3344433
P698PubMed publication ID3344433

P50authorJoseph L. GoldsteinQ271424
P2093author name stringD W Russell
M S Brown
S L Hofmann
R E Hammer
P2860cites workThe human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNAQ24300736
Genomic sequencingQ24594942
Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbitsQ24628996
Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseQ26778460
Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoterQ27861016
A receptor-mediated pathway for cholesterol homeostasisQ29616158
Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genesQ34274059
mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbitsQ34344169
Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemiaQ35346270
Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 alpha-ethinyl estradiolQ35589157
A domain-specific marker for the hepatocyte plasma membrane: localization of leucine aminopeptidase to the bile canalicular domainQ36207387
Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblastsQ36208347
Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggsQ37545665
Receptor-mediated endocytosis: concepts emerging from the LDL receptor systemQ39461911
Germ-line transformation of miceQ39757195
Metallothionein-Human GH Fusion Genes Stimulate Growth of MiceQ40161822
Partial correction of murine hereditary growth disorder by germ-line incorporation of a new geneQ45862925
Structure and evolution of the insulin geneQ69924638
19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cellsQ70193016
Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspringQ70448542
A practical approach for quantitating specific mRNAs by solution hybridizationQ71021350
Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopyQ71856673
Recovery of DNA segments from agarose gelsQ72846172
P433issue4845
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
overexpressionQ61643320
P304page(s)1277-1281
P577publication date1988-03-01
P1433published inScienceQ192864
P1476titleOverexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice
P478volume239

Reverse relations

cites work (P2860)
Q41653377A synthetic peptide mimic of plasma apolipoprotein E that binds the LDL receptor
Q36201407Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice
Q34497951Apolipoprotein E: From lipid transport to neurobiology
Q44158115Arterial hardening in mice
Q37388151Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).
Q67937712Cyclosporine, low-density lipoprotein, and cholesterol
Q36531225Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice
Q43734161Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase
Q34263181Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors
Q33645475Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitro
Q28510584Endoglin is required for myogenic differentiation potential of neural crest stem cells
Q35526805Experimental and clinical applications of molecular cell biology in nutrition and metabolism
Q40905171Exploring pathogenetic mechanisms using transgenic animals
Q35205250From diet to DNA: dietary patterning of gene expression
Q40559434Genetic models of human vascular disease
Q54575442Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein.
Q39883795Hepatitis B virus induces expression of cholesterol metabolism-related genes via TLR2 in HepG2 cells
Q29615235Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
Q33832739Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits
Q39559406Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis
Q34258604Koch's postulates for cholesterol
Q40588222Lipoproteins and their functions
Q41063915Liver-directed gene transfer and application to therapy
Q42836644Low-density-lipoprotein receptors in different rabbit liver cells
Q35588973Lowering cholesterol, 1988. Rationale, mechanisms, and means
Q60045905Lucky, times ten: A career in Texas science
Q35788419Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency
Q40601689Molecular biology and gene transfer in atherosclerosis in the stenting era.
Q58136301Molecular genetics of familial hypercholesterolaemia: common and rare mutations of the low density lipoprotein receptor gene
Q34291227Multiplex gene regulation: a two-tiered approach to transgene regulation in transgenic mice
Q24306058Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
Q36857781Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia
Q34250947Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice
Q30274556Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance
Q44509776Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.
Q37360326Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
Q41021318Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.
Q44317088Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice
Q24798892Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.
Q36434617Recent developments in the treatment of atherosclerosis
Q36649344Sequences containing the second-intron enhancer are essential for transcription of the human apolipoprotein B gene in the livers of transgenic mice
Q28585606Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure
Q33338471Spatial relational memory requires hippocampal adult neurogenesis
Q24297663Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor
Q40802362The biology of the artery wall in atherogenesis.
Q35604030The familial hypercholesterolemia (FH)-North Karelia mutation of the low density lipoprotein receptor gene deletes seven nucleotides of exon 6 and is a common cause of FH in Finland
Q89706215The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats
Q36844564The use of transgenic animals to study the role of growth factors in endocrinology
Q36223333Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice
Q40527453Transcriptional control of the human apolipoprotein B gene in cell culture and in transgenic animals.
Q69352129Transgenic animals
Q36525382Transgenic mouse models of lipoprotein metabolism and atherosclerosis