The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats

scientific article published on 13 February 2020

The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/S40169-020-0265-2
P932PMC publication ID7018876
P698PubMed publication ID32056048

P50authorXinyang LiQ89706213
P2093author name stringShuang Yang
Xiuqing Zhang
Bo Li
Xiaoyan Gao
Xinhua Zhang
Lin Jiang
Yong Hou
Naibo Yang
Yingying Ma
Mi Huang
Haitao Xiang
Xiaopan Liu
Chuxin Liu
Meiniang Wang
P2860cites workPCSK9 Inhibitors: Mechanism of Action, Efficacy, and SafetyQ91400753
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiationQ24293346
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic miceQ24311328
Mutations in PCSK9 cause autosomal dominant hypercholesterolemiaQ28202519
Selection and identification of single domain antibody fragments from camel heavy-chain antibodiesQ28250517
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trialsQ29617910
Isolation of antigen specific llama VHH antibody fragments and their high level secretion by Saccharomyces cerevisiaeQ30843840
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic miceQ34175241
Bacterial cytoplasm as an effective cell compartment for producing functional VHH-based affinity reagents and Camelidae IgG-like recombinant antibodiesQ34234412
Generation of single domain antibody fragments derived from camelids and generation of manifold constructsQ34386048
Off-rate screening for selection of high-affinity anti-drug antibodiesQ34887838
Comparative Analysis of Immune Repertoires between Bactrian Camel's Conventional and Heavy-Chain AntibodiesQ36121467
Progression of vascular calcification is increased with statin use in the Veterans Affairs Diabetes Trial (VADT).Q36334643
Prokaryotic expression of antibodiesQ36366522
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levelsQ36481769
Plasma PCSK9 levels are significantly modified by statins and fibrates in humansQ36728777
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1aQ37360326
Therapeutic antibodies: successes, limitations and hopes for the futureQ37491236
Pichia pastoris: a recombinant microfactory for antibodies and human membrane proteins.Q38104572
Half-life extended biotherapeuticsQ38770067
Caplacizumab reduces the frequency of major thromboembolic events, exacerbations and death in patients with acquired thrombotic thrombocytopenic purpuraQ38818496
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor DegradationQ38855416
Statins and Their Effect on PCSK9-Impact and Clinical RelevanceQ38868416
Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono- and bispecific antibodiesQ39557682
PCSK9 inhibitors may improve cardiovascular outcomes-Can we afford them?Q39623145
Increased half-life and enhanced potency of Fc-modified human PCSK9 monoclonal antibodies in primates.Q41443645
Proprotein convertase subtilisin/Kexin type 9 (PCSK9) single domain antibodies are potent inhibitors of low density lipoprotein receptor degradationQ41834894
Expression of single-chain variable fragments fused with the Fc-region of rabbit IgG in Leishmania tarentolaeQ41931233
Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance.Q44442238
A comparison of strategies to stabilize immunoglobulin Fv-fragmentsQ46093365
Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.Q46857204
Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritisQ49082819
Quality and cost assessment of a recombinant antibody fragment produced from mammalian, yeast and prokaryotic host cells: A case study prior to pharmaceutical development.Q54204604
A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 miceQ58454981
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9Q90949040
Current Drugs and Nutraceuticals for the Treatment of Patients with DyslipidemiasQ91301940
P433issue1
P304page(s)16
P577publication date2020-02-13
P1433published inClinical and translational medicineQ27724586
P1476titleThe novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats
P478volume9

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Q99636619Exploring cellular biochemistry with nanobodiescites workP2860

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