Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

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Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M306540200
P698PubMed publication ID12855691

P50authorShinji IkemotoQ68620379
Jay D HortonQ89378224
P2093author name stringIichiro Shimomura
Robert E Hammer
Yuriy Bashmakov
P2860cites workSREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory elementQ24318461
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cellsQ24561820
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factorQ28238069
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor geneQ28264180
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13Q28301916
Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expressionQ28379103
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 geneQ28584842
Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteinsQ28646552
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene deliveryQ29615235
A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivoQ33923356
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic miceQ34175241
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liverQ34664294
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophyQ35210714
Cellular and molecular aspects of adipose tissue developmentQ35706230
ADD1/SREBP1 activates PPARgamma through the production of endogenous ligandQ36471774
ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiationQ36694542
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetesQ36698641
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liverQ36806480
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1aQ37360326
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cellsQ37364195
Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoterQ38292537
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitusQ38319698
Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolismQ39446637
Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activatorsQ41082185
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolismQ42813608
The purification and properties of microsomal palmitoyl-coenzyme A synthetaseQ42922213
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.Q52895402
P433issue38
P407language of work or nameEnglishQ1860
P921main subjectadipocyteQ357519
fatty acidQ61476
overexpressionQ61643320
P304page(s)36652-36660
P577publication date2003-07-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleOverexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver
P478volume278

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