Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes

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Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1047227671
P356DOI10.1038/300611A0
P932PMC publication ID4881848
P698PubMed publication ID6958982

P2093author name stringM G Rosenfeld
R M Evans
R E Hammer
R D Palmiter
R L Brinster
M E Trumbauer
N C Birnberg
P2860cites workTranscriptional regulation of the mouse metallothionein-I gene by heavy metalsQ70797480
The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cellsQ72045401
Recovery of DNA segments from agarose gelsQ72846172
Synthesis and release of human growth hormone from lung carcinoma in cell cultureQ93716312
Genetic transformation of mouse embryos by microinjection of purified DNAQ24608157
Direct expression in Escherichia coli of a DNA sequence coding for human growth hormoneQ28305861
Stimulation of growth in the little mouseQ28513361
Integration and Stable Germ Line Transmission of Genes Injected into Mouse PronucleiQ34252877
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggsQ34253051
Introduction of a rabbit beta-globin gene into the mouse germ lineQ34273747
Effect of Exogenous Growth Hormone on Lactational Performance in High Yielding Dairy CowsQ34283511
Primary structure and evolution of rat growth hormone geneQ35458269
The human beta-globin gene and a functional viral thymidine kinase gene in developing mice.Q35463665
Transformation of frog embryos with a rabbit beta-globin geneQ35464659
Introduction of rat growth hormone gene into mouse fibroblasts via a retroviral DNA vector: expression and regulationQ36289669
Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspringQ36375465
Thyrotropin-releasing hormone exerts rapid nuclear effects to increase production of the primary prolactin mRNA transcriptQ36377131
Expression of two human growth hormone genes in monkey cells infected by simian virus 40 recombinantsQ36382125
Growth hormone and the regulation of somatic growthQ37367776
Brain peptides (first of two parts).Q40083919
The regulation of growth by endocrinesQ40682318
Structure of mouse metallothionein-I gene and its mRNA.Q42268759
Growth hormone and the adipose conversion of 3T3 cellsQ42825109
Regulation of metallothionein–thymidine kinase fusion plasmids injected into mouse eggsQ48405546
Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal.Q53569555
Solubilization and purification of a prolactin receptor from the rabbit mammary gland.Q54647924
Regulated expression of human growth hormone genes in mouse cellsQ62059799
Pituitary adenomas in childhood and adolescenceQ67356469
Ectopic growth-hormone production and osteoarthropathy in carcinoma of the bronchusQ70083464
Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspringQ70448542
P433issue5893
P407language of work or nameEnglishQ1860
P304page(s)611-615
P577publication date1982-12-01
P1433published inNatureQ180445
P1476titleDramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes
P478volume300

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cites work (P2860)
Q73311056'Molecular farming' of antibodies in plants
Q41703005A consideration of some notable aging theories
Q48247606A dietary supplement abolishes age-related cognitive decline in transgenic mice expressing elevated free radical processes
Q35550198A future for transgenic livestock.
Q35290041A molecular biological approach to reducing dietary amino acid needs
Q48723423A multi-ingredient dietary supplement abolishes large-scale brain cell loss, improves sensory function, and prevents neuronal atrophy in aging mice
Q37366031A non-surgical approach for male germ cell mediated gene transmission through transgenesis
Q34381923A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
Q31423344A transgenic mouse expressing human CYP1A2 in the pancreas
Q37359089Accelerated growth and visceral lesions in transgenic mice expressing foreign genes of the growth hormone family: an overview
Q37375570Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice.
Q37125980Age-related changes in body composition of bovine growth hormone transgenic mice
Q28593220Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
Q37352313Altering nutrient utilization in animals through transgenesis
Q39816011An appraisal of the application of recombinant DNA techniques to chromosome defects
Q36887080Analysis of a transgenic mouse containing simian virus 40 and v-myc sequences
Q35817599Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes
Q36631641Animal models of skin disease for drug discovery.
Q34608788Animal transgenesis: state of the art and applications
Q44850419Antisense Inhibition of β-Glucuronidase Expression in Preimplantation Mouse Embryos: A Comparison of Transgenes and Oligodeoxynucleotides
Q36587260Application of recombinant DNA technologies to studies on chicken growth hormone
Q37508177Assessment of fecundity and germ line transmission in two transgenic pig lines produced by sleeping beauty transposition
Q50790654Association of (3H) DNA with fowl spermatozoa and their in vitro fertilisation of hamster ova
Q49588153Avian Biotechnology
Q35186506Behavioural and physiological characterization of inbred mouse strains: prospects for elucidating the molecular mechanisms of mammalian learning and memory
Q39737833Beta cell expression of IGF-I leads to recovery from type 1 diabetes.
Q33930330Biogerontological research in Canada
Q39691811Biotechnology and production-related hormones
Q37036325Body-enlarging effect of royal jelly in a non-holometabolous insect species, Gryllus bimaculatus.
Q35588234Brains, genes, and primates
Q35655803Breeding and transgenesis as means of decreasing adiposity in farm animal species: practice and promise
Q37259329Breeding for disease resistance--the prospective role of genetic manipulation
Q42471375CD14 transgenic mice expressing membrane and soluble forms: comparisons of levels of cytokines and lethalities in response to lipopolysaccharide between transgenic and non-transgenic mice
Q35209756CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
Q34386193Cancer immunotherapy: insights from transgenic animal models
Q35762709Capricious Cre: the devil is in the details
Q48894839Caprine blastocyst development after in vitro fertilization with spermatozoa frozen in different extenders
Q33191658Cell-specific expression of a Clara cell secretory protein-human growth hormone gene in the bronchiolar epithelium of transgenic mice
Q28585768Characterization and localization of mouse hypothalamic growth hormone-releasing factor and effect of gold thioglucose-induced hypothalamic lesions
Q40914931Chemical regulation of transgene expression in plants
Q70671273Chromosomal transplantation. The nuclear transplantation of colchicine-treated cells
Q27931785Cloning and expression of a yeast copper metallothionein gene
Q35630884Conditional Cripto overexpression in satellite cells promotes myogenic commitment and enhances early regeneration
Q74603817Consequences of overexpression of growth hormone in transgenic mice on liver cytochrome P450 enzymes
Q38980833Construction of a recombinant human insulin expression vector for mammary gland-specific expression in buffalo (Bubalus bubalis) mammary epithelial cell line
Q34334407Consuming transgenic goats' milk containing the antimicrobial protein lysozyme helps resolve diarrhea in young pigs
Q36268666Copper metallothionein of yeast, structure of the gene, and regulation of expression
Q59053963Correcting an immune-response deficiency by creating Eα gene transgenic mice
Q37403955Crosstalk between growth hormone and insulin signaling
Q34659803Cruciform-extruding regulatory element controls cell-specific activity of the tyrosine hydroxylase gene promoter
Q33743426Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice.
Q41566520DNA binding properties of glucocorticosteroid receptors bound to the steroid antagonist RU-486
Q36573408Decompartmentalizing target validation-thinking outside the pipeline boxes
Q47432294Decreased frequency of the rat growth hormone transgene in mouse populations with or without selection for increased adult body weight
Q36753290Derepression of human embryonic zeta-globin promoter by a locus-control region sequence
Q33873910Developing efficient strategies for the generation of transgenic cattle which produce biopharmaceuticals in milk
Q53802217Development of a positive method for male stem cell-mediated gene transfer in mouse and pig.
Q41714073Development of expression vectors for transgenic fish
Q70972856Development of obesity following inactivation of a growth hormone transgene in mice
Q51842182Development of transgenic fish for ornamental and bioreactor by strong expression of fluorescent proteins in the skeletal muscle.
Q52457371Developmental control of transduced dopa decarboxylase genes in D. melanogaster.
Q70409679Developmental fate of a human insulin gene in a transgenic mouse
Q36903431Developmental regulation of alpha-fetoprotein genes in transgenic mice
Q40517143Differential expression of jun and fos genes during differentiation of mouse P19 embryonal carcinoma cells
Q74474271Differential in vivo activities of bovine growth hormone analogues
Q30449971Differentiation, not determination, regulates muscle gene activation: transfection of troponin I genes into multipotential and muscle lineages of 10T1/2 cells
Q70313579Direct alteration of a gene in the human genome
Q34631775Direct gene transfer into human cultured cells facilitated by laser micropuncture of the cell membrane
Q35882691Direct sequencing of PCR-amplified junction fragments from tandemly repeated transgenes
Q37579154Direct transfection of viral and plasmid DNA into the liver or spleen of mice
Q37117583Domestication and growth hormone transgenesis cause similar changes in gene expression in coho salmon (Oncorhynchus kisutch).
Q35904811Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons
Q40053591Drug discovery paradigms: past, present, future - a centennial symposium of the American Society for Pharmacology and Experimental Therapeutics
Q50612461Effect of crotamine, a cell-penetrating peptide, on blastocyst production and gene expression of in vitro fertilized bovine embryos.
Q44870357Effect of genetic background on growth of mice hemizygous for wild-type or dwarf mutated bovine growth hormone transgenes
Q46973436Effects of an S84E mutation of bovine growth hormone in transgenic mice
Q34258343Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern, and myosin adenosine triphosphatase activity of rat left ventricle
Q73055528Effects of chronically elevated growth hormone levels on polyamine metabolism in elderly transgenic mice
Q34231665Effects of growth hormone and its secretagogues on bone.
Q50482608Effects of long-term in vitro culturing of transgenic bovine donor fibroblasts on cell viability and in vitro developmental potential after nuclear transfer.
Q70460523Effects of the expression of bovine growth hormone on the testes and male accessory reproductive glands in transgenic mice
Q35821035Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease
Q54959432Efficient Generation of Transgenic Buffalos (Bubalus bubalis) by Nuclear Transfer of Fetal Fibroblasts Expressing Enhanced Green Fluorescent Protein.
Q39874162Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells
Q35590811Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner
Q33892161Embryonic and genetic manipulation in fish.
Q41946940Embryonic stem cell differentiation models: cardiogenesis, myogenesis, neurogenesis, epithelial and vascular smooth muscle cell differentiation in vitro.
Q40771048Endocrine regulation of longitudinal bone growth.
Q34381917Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).
Q37619960European community and US-FDA approval of recombinant human antithrombin produced in genetically altered goats
Q37619460Evaluation of growth hormone (GH) action in mice: discovery of GH receptor antagonists and clinical indications
Q47732033Evaluation of the safety of daily administration of capromorelin in cats
Q33792575Ex vivo magnetofection: a novel strategy for the study of gene function in mouse organogenesis
Q42532915Expression of Growth Hormone Genes in Transgenic Mice
Q41880877Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice
Q77704854Expression of a novel piscine growth hormone gene results in growth enhancement in transgenic tilapia (Oreochromis niloticus)
Q33932178Expression of foreign genes from retroviral vectors in mouse teratocarcinoma chimaeras.
Q67529784Expression of human alpha 1 antitrypsin in transgenic sheep
Q48488820Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth.
Q40768879Expression of insulin-like growth factor-I in transgenic mice
Q70163257Expression of the chicken transferrin gene in transgenic mice
Q33665584Expression of the human growth hormone variant gene in cultured fibroblasts and transgenic mice
Q68928702Expression of the pancreatic elastase I gene in transgenic mice
Q79141724Expression vehicles used in recombinant DNA technology
Q59059825Extraordinary salmon growth
Q37545665Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs
Q40632699Five decades of progress in management of the infertile couple.
Q32036518Foreign DNA introduced into the vas deferens is gained by mammalian spermatozoa
Q34267275Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
Q48469839Frequency dependency of NMDA receptor-dependent synaptic plasticity in the hippocampal CA1 region of freely behaving mice
Q26781859From Gene Targeting to Genome Editing: Transgenic animals applications and beyond
Q58161857From mapping to manipulating the vertebrate genome
Q73676243From mighty mice to mighty cows
Q38146639Frontiers in mammalian cell culture
Q34462487Full-speed mammalian genetics: in vivo target validation in the drug discovery process
Q36945352Functional genomics of the chicken--a model organism.
Q39287747GH and ageing: Pitfalls and new insights
Q38495952Gastrocnemius transcriptome analysis reveals domestication induced gene expression changes between wild and domestic chickens
Q64448553Gene Transfer into Sheep
Q37710895Gene delivery to Nile tilapia cells for transgenesis and the role of PI3K-c2α in angiogenesis
Q34114590Gene targeting in livestock: a preview
Q38174163Gene targeting technologies in rats: zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats
Q70935363Gene therapy
Q36386450Gene therapy for pituitary tumors.
Q35647626Gene transfer and genome-wide insertional mutagenesis by retroviral transduction in fish stem cells
Q58281279Gene transfer in fish: Potential and practice
Q34804785Gene transfer in higher animals: theoretical considerations and key concepts
Q39692912Gene transfer into mice
Q46855972Gene transfer, expression and inheritance of pRSV-rainbow trout-GH cDNA in the common carp, Cyprinus carpio (Linnaeus).
Q61800727Generating mouse models for biomedical research: technological advances
Q88016594Generation of genetically modified mice using CRISPR/Cas9 and haploid embryonic stem cell systems
Q70150161Generation of transgenic mice producing a human transthyretin variant: a possible mouse model for familial amyloidotic polyneuropathy
Q33669930Generation of transgenic mice with elevated blood pressure by introduction of the rat renin and angiotensinogen genes
Q40075612Genetic control theory of developmental events
Q37555007Genetic dissection of neural circuits and behavior in Mus musculus.
Q28743531Genetic engineering of a mouse: Dr. Frank Ruddle and somatic cell genetics
Q86824722Genetic manipulation in plant breeding: somatic versus generative
Q34151342Genetic manipulation of sex differentiation and phenotype in domestic animals
Q69752307Genetic transformation of chickens using irradiated male gametes
Q38714831Genetically engineered livestock for agriculture: a generation after the first transgenic animal research conference
Q36818129Genetically manipulated mice: a powerful tool with unsuspected caveats
Q39757195Germ-line transformation of mice
Q41278601Germline transmission of exogenous genes in chickens using helper-free ecotropic avian leukosis virus-based vectors
Q77630788Green fluorescent protein (GFP) transgenic fish and their applications
Q43770642Growth and endocrine effect of growth hormone transgene dosage in diploid and triploid coho salmon
Q45020496Growth hormone and epidermal growth factor in salivary glands of giant and dwarf transgenic mice
Q39469085Growth hormone and its modulation.
Q36015309Handmade cloned transgenic piglets expressing the nematode fat-1 gene
Q33194830Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse
Q90259593Harnessing genomic information for livestock improvement
Q74582676Hepatocellular kinetics and the expression of growth hormone (GH) in the livers and liver tumours of GH-transgenic mice
Q43470250Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
Q67528049High level expression of active human alpha-1-antitrypsin in the milk of transgenic sheep
Q37592004High-frequency germ-line transmission of plasmid DNA sequences injected into fertilized zebrafish eggs
Q33672151High-level expression of biologically active human alpha 1-antitrypsin in the milk of transgenic mice
Q47960621High-level expression of recombinant human fibrinogen in the milk of transgenic mice
Q35599123Human growth hormone (hGH) secretion in milk of goats after direct transfer of the hGH gene into the mammary gland by using replication-defective retrovirus vectors
Q67954220Identification of a variant growth hormone haplotype in mice selected for high body weight
Q34479096Identified and unidentified challenges for reproductive biotechnologies regarding infectious diseases in animal and public health
Q81739215Igf-I and postnatal growth of weaver mutant mice
Q50246481In vivo gene transfer in mouse preimplantation embryos after intraoviductal injection of plasmid DNA and subsequent in vivo electroporation
Q52363995In vivo genome editing thrives with diversified CRISPR technologies.
Q30486155Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis
Q49407511Incorporation of a skeletal muscle-specific enhancer in the regulatory region of Igf1 upregulates IGF1 expression and induces skeletal muscle hypertrophy.
Q36949196Inducibility of metallothionein throughout the cell cycle
Q41450456Inducible cellular transformation by a metallothionein-ras hybrid oncogene leads to natural killer cell susceptibility
Q59057608Induction of self-tolerance in mature peripheral B lymphocytes
Q45085478Infectious and Selectable Retrovirus Containing an Inducible Rat Growth Hormone Minigene
Q28286762Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination
Q36064514Introduction and expression of the bacterial genes cysE and cysK in eukaryotic cells
Q54578577Introduction and expression of the bacterial glyoxylate cycle genes in transgenic mice.
Q40078935Introduction of Purified Genes Into Mammalian Cell
Q37577456Introduction of a selectable gene into different animal tissue by a retrovirus recombinant vector
Q36957536Introduction of genes into the germ line of animals
Q82467878Introduction: Strategies for Developing Genetically Modified Mice
Q51805244Isolation of yellow catfish β-actin promoter and generation of transgenic yellow catfish expressing enhanced yellow fluorescent protein.
Q53669003Jewish bioethics and medical genetics.
Q33777892Knock your SOCS off!
Q34424075Knock-in of Enhanced Green Fluorescent Protein or/and Human Fibroblast Growth Factor 2 Gene into β-Casein Gene Locus in the Porcine Fibroblasts to Produce Therapeutic Protein
Q48118403Lactotroph hyperplasia in the pituitaries of female mice expressing high levels of bovine growth hormone
Q33636494Leptin receptor modulation of adiposity and fertility
Q52213037Liver, renal and subcutaneous histopathology in PEPCK-bGH transgenic pigs.
Q57271413Manipulating DNA: from Cloning to Knockouts
Q74587447Manipulation of gene expression in the mammalian nervous system: application in the study of neurite outgrowth and neuroregeneration-related proteins
Q54247120Manipulation of the repertoire of digestive enzymes secreted into the gastrointestinal tract of transgenic mice.
Q36787518Meiotic expression of human ornithine transcarbamylase in the testes of transgenic mice
Q47754084Metal ion-responsive transgenic Xenopus laevis as an environmental monitoring animal
Q34661387Metal-binding proteins as metal pollution indicators
Q40161822Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice
Q35856545Mice transgenic for a vasopressin-SV40 hybrid oncogene develop tumors of the endocrine pancreas and the anterior pituitary. A possible model for human multiple endocrine neoplasia type 1.
Q36258260Microinsemination and nuclear transfer using male germ cells
Q51896478Microtubules are involved in regulating body length in hydra
Q72800974Mini-mouse: phenotypic characterization of a transgenic insertional mutant allelic to pygmy
Q36838387Mitogenic signaling pathways in the liver of growth hormone (GH)-overexpressing mice during the growth period
Q38541790Molecular Genetic Strategies in the Study of Corticohippocampal Circuits
Q39654136Molecular aspects, physiological function, and clinical significance of metallothioneins
Q35205259Molecular biology in nutrition
Q37782846Molecular biology of the insulin-like growth factors. Relevance to nervous system function
Q71111704Molecular biology. Enhancers, chromosome position effects, and transgenic mice
Q42491592Morphological changes in the kidney of dogs chronically exposed to exogenous growth hormone
Q37611843Mosaic expression of a tyrosinase fusion gene in albino mice yields a heritable striped coat color pattern in transgenic homozygotes
Q27490350Mouse models in liver cancer research: A review of current literature
Q47069162Mutants carrying two sma mutations are super small in the nematode C. elegans
Q34063520My career path for developing gene therapy for blinding diseases: the importance of mentors, collaborators, and opportunities
Q37236327Natural genotypes via genetic engineering
Q34134065Neuron addition and enlargement in juvenile and adult animals
Q35222165Neuropeptide gene expression in transgenic animals
Q78009654New life for sperm-mediated transgenesis?
Q39025466Non-conventional expression systems for the production of vaccine proteins and immunotherapeutic molecules
Q38115497Novel GM animal technologies and their governance.
Q48453883Novel developmental specificity in the nervous system of transgenic animals expressing growth hormone fusion genes
Q69378455Novel restriction fragment length polymorphism of the growth hormone gene in inbred rats
Q34617382One Hundred Years of Mouse Genetics: An Intellectual History. II. The Molecular Revolution (1981-2002)
Q36673385Optimization of The Electroporation Conditions for Transfection of Human Factor IX into The Goat Fetal Fibroblasts
Q38549724Organ-Size Regulation in Mammals
Q36706772Osteoblast-specific expression of growth hormone stimulates bone growth in transgenic mice
Q67660860Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
Q37146368Overexpression of Xenopus laevis growth hormone stimulates growth of tadpoles and frogs
Q34175241Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice
Q86630619Oxidative stress in hypopituitary dwarf mice and in transgenic mice overexpressing human and bovine GH
Q35599755Pancreatic expression of human insulin gene in transgenic mice.
Q45862925Partial correction of murine hereditary growth disorder by germ-line incorporation of a new gene
Q43217675Patterning the artery wall by lateral induction of Notch signaling
Q67863178Patterns of transgene inheritance in rainbow trout (Oncorhynchus mykiss)
Q45737657Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice
Q73820183Phosphorus-friendly transgenics
Q40769486Plant metallothioneins
Q24611750Precision editing of large animal genomes
Q33540638Precision genetics for complex objectives in animal agriculture
Q54625912Preventing hair loss in mice.
Q36766444Primer: molecular tools used for the understanding of endocrinology.
Q37596801Prion disease: experimental models and reality
Q44869823Production and breeding of transgenic cattle using in vitro embryo production technology
Q38522594Production of human lactoferrin and lysozyme in the milk of transgenic dairy animals: past, present, and future
Q36709428Production of transgenic mice by microinjection of DNA into vitrified pronucleate stage eggs
Q41616749Production of transgenic mice from vitrified pronuclear-stage embryos.
Q34193902Production of transgenic rabbits, sheep and pigs by microinjection
Q34275662Production of transgenic rodents by the microinjection of cloned DNA into fertilized one-cell eggs
Q37356657Progress in gene transfer by germ cells in mammals
Q39581991Prolactin and growth hormone
Q38224243Promising future for the transgenic rat in transplantation research
Q36922184Promoter and enhancer elements from the rat elastase I gene function independently of each other and of heterologous enhancers
Q34712084Promoter efficiency depends upon intragenic sequences
Q72399477Prospects for Human Gene Therapy
Q46962386Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth
Q35927577Public health issues related with the consumption of food obtained from genetically modified organisms
Q33968166Quantitative genetics of transgenic mice: components of phenotypic variation in body weights and weight gains.
Q38732853RNAe in a transgenic growth hormone mouse model shows potential for use in gene therapy
Q35744332Rapid growth accelerates telomere attrition in a transgenic fish
Q44057320Rearrangements of microinjected recombinant DNA in the genome of transgenic mice
Q40892666Recent advances in transgenic technology
Q33606158Recombinant DNA in medicine
Q35062979Regulating the angiogenic balance in tissues
Q36797664Regulation of expression of a sheep metallothionein 1a-sheep growth hormone fusion gene in transgenic mice.
Q68583023Relative growth of the skull and postcranium in giant transgenic mice
Q52569977Reproduction in Domestic Ruminants during the Past 50 Years: Discovery to Application.
Q52244133Restriction fragment length variations and chromosome mapping of two mouse metallothionein genes, Mt-1 and Mt-2.
Q37914475Rodent laparoscopy: refinement for rodent drug studies and model development, and monitoring of neoplastic, inflammatory and metabolic diseases
Q33742098Role of growth hormone and prolactin in the control of reproduction: what are we learning from transgenic and knock-out animals?
Q80060734Role of the GH/IGF-I axis in the growth retardation of weaver mice
Q28508170SOCS2 negatively regulates growth hormone action in vitro and in vivo
Q34218612Scavenger receptor A gene regulatory elements target gene expression to macrophages and to foam cells of atherosclerotic lesions
Q47147062Scientific report on the effects of farming systems on dairy cow welfare and disease
Q40076283Scope of DNA cloning and chemical methods in development of chemotherapeutic agents
Q40692299Seiji Memorial Lecture. Transgene expression in melanocytes
Q47399441Selection for increased adult body weight in mouse lines with and without the rat growth hormone transgene
Q48878155Selection of in vitro produced, transgenic embryos by nested PCR for efficient production of transgenic goats
Q30631282Sex-specific analysis of bone mass in normal and growth hormone transgenic mice using dual energy x-ray absorptiometry (DXA)
Q43822327Sleep of transgenic mice producing excess rat growth hormone
Q40922217Somatic gene therapy. Current status and future prospects
Q41907365Somatic growth, aging, and longevity
Q40142821Some clinical implications of recombinant DNA technology with emphasis on prenatal diagnosis of hemoglobinopathies
Q47548145Streamlined ex vivo and in vivo genome editing in mouse embryos using recombinant adeno-associated viruses.
Q33880195Studies on the expression of an H-2K/human growth hormone fusion gene in giant transgenic mice
Q44392444Studies on the thyroid in transgenic mice expressing the genes for human and bovine growth hormone
Q57197999Systemic overexpression of growth hormone (GH) in transgenic FVB/N inbred mice: an optimized model for holistic studies of molecular mechanisms underlying GH-induced kidney pathology
Q35074875Tailoring the genome: the power of genetic approaches
Q33853035Targeted deletion of somatotroph insulin-like growth factor-I signaling in a cell-specific knockout mouse model
Q37372495Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice
Q24631266Targeted transgenesis
Q37631906Technical advances in rhinologic basic science research.
Q34990916Technical approaches for mouse models of human disease
Q35744479Technologies for the control of fat and lean deposition in livestock
Q36559706Testis-specific expression of a metallothionein I-driven transgene correlates with undermethylation of the locus in testicular DNA.
Q35644970The Effect of Cage Space on Behavior and Reproduction in Crl:CD1(Icr) and C57BL/6NCrl Laboratory Mice
Q33817029The GH/IGF-1 axis in ageing and longevity
Q82345634The GH/IGF-1 axis in growth and development: new insights derived from animal models
Q37044921The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death
Q48684446The IGF-I receptor in cell growth, transformation and apoptosis
Q28776550The analysis of ontogenetic trajectories: when a change in size or shape is not heterochrony
Q52517175The cloned dopa decarboxylase gene is developmentally regulated when reintegrated into the drosophila genome
Q40942515The commercial and agricultural applications of animal transgenesis
Q28244375The construction of transgenic and gene knockout/knockin mouse models of human disease
Q33228041The effect of DNA repair defects on reproductive performance in nucleotide excision repair (NER) mouse models: an epidemiological approach
Q41656283The effect of apo E secretion on lipoprotein uptake in transfected cells
Q71918825The effect of insulin-like growth factor-1 on adult rat cardiac contractility
Q30053464The genetic engineering of production traits in domestic animals
Q48072556The growth hormone-encoding gene isolated and characterized from Labeo rohita Hamilton is expressed in CHO cells under the control of constitutive promoters in 'autotransgene' constructs
Q36934464The growth hormone-insulin-like growth factor-I axis in chronic kidney disease
Q38162743The integrated development and application of controlled reproduction techniques in Pacific salmonid aquaculture
Q33902482The mammary gland as a bioreactor: expression, processing, and production of recombinant proteins
Q41175237The mechanisms by which growth hormone brings about growth. The relative contributions of growth hormone and insulin-like growth factors
Q44079492The methods to generate transgenic animals and to control transgene expression
Q34258836The molecular genetics of human hemoglobin
Q38339614The new genetics: molecular technology and reproductive biology.
Q47774301The proximal 350 bp of 5'-flanking sequence of the human α-subunit glycoprotein hormone gene functions in the pituitary gland, but not the placenta, in transgenic mice
Q70463013The role of growth hormone in lines of mice divergently selected on body weight
Q37608512The role of insulin-like growth factor during a postischemic period - new insights into pathophysiologic pathways in cardiac tissue
Q35577270The transgenic rabbit as model for human diseases and as a source of biologically active recombinant proteins.
Q41074292The use of null mutant mice to study complex learning and memory processes
Q36844564The use of transgenic animals to study the role of growth factors in endocrinology
Q33850269Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency
Q44716680Tissue- and developmental stage-specific expression of the rat ornithine carbamoyltransferase gene in transgenic mice
Q33740724Tissue-specific expression and methylation of a thyroglobulin-chloramphenicol acetyltransferase fusion gene in transgenic mice
Q39753875Tissue-specific expression of pancreatic genes in transgenic mice
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Q34608704Transgenic systems in drug discovery: from target identification to humanized mice
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Q59079278Tumour development: Oncogenes in transgenic mice
Q48921146Uncertainties about 'painless' animals
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Q34578774Welfare issues of genetically modified animals
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Q69851348[Current status of biotechnology in animal breeding]
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