Insight on the molecular envelope of lipid-bound apolipoprotein E from electron paramagnetic resonance spectroscopy.

scientific article published on 24 December 2008

Insight on the molecular envelope of lipid-bound apolipoprotein E from electron paramagnetic resonance spectroscopy. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2008.12.040
P932PMC publication ID2665048
P698PubMed publication ID19124026
P5875ResearchGate publication ID23759068

P50authorJohn C VossQ42734173
Danny M. HattersQ45293201
P2093author name stringKarl H Weisgraber
Madhu S Budamagunta
Yvonne N Newhouse
P2860cites workApolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer diseaseQ22248076
Structural determinants of nitroxide motion in spin-labeled proteins: Tertiary contact and solvent-inaccessible sites in helix G of T4 lysozymeQ27644663
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein EQ27663468
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoformsQ27730887
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset familiesQ27860677
Apolipoprotein E: cholesterol transport protein with expanding role in cell biologyQ28294791
Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein EQ28508278
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's diseaseQ29614952
Crystal structures of spin labeled T4 lysozyme mutants: implications for the interpretation of EPR spectra in terms of structure.Q30327038
Membrane structure of protein kinase C and calmodulin binding domain of myristoylated alanine rich C kinase substrate determined by site-directed spin labelingQ30468179
Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in miceQ30486146
A ruler for determining the position of proteins in membranesQ30988159
Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyondQ33702396
Molecular basis of exchangeable apolipoprotein functionQ33796767
The plasma lecithins:cholesterol acyltransferase reactionQ34220638
Crystallization and preliminary X-ray diffraction analysis of apolipoprotein E-containing lipoprotein particlesQ35994883
Apolipoprotein E structure: insights into function.Q36527194
Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblastsQ40224633
Apolipoprotein E: structure-function relationshipsQ40737965
Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coliQ41681565
Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related proteinQ41709963
Conformational reorganization of the four-helix bundle of human apolipoprotein E in binding to phospholipidQ41734798
Lipid association-induced N- and C-terminal domain reorganization in human apolipoprotein E3.Q43694392
Effect of domain interaction on apolipoprotein E levels in mouse brain.Q44267254
The C-terminal domain of apolipoprotein A-I contains a lipid-sensitive conformational triggerQ44446009
Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitroQ45081026
Electron paramagnetic resonance spectroscopy of site-directed spin labels reveals the structural heterogeneity in the N-terminal domain of apoA-I in solutionQ46154671
Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrilsQ46212443
Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domainsQ46421943
Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.Q46620615
Apolipoprotein E*dipalmitoylphosphatidylcholine particles are ellipsoidal in solutionQ46629889
Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteinsQ46656933
Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholineQ46797037
Micellar complexes of human apolipoprotein A-I with phosphatidylcholines and cholesterol prepared from cholate-lipid dispersions.Q50934373
Apolipoprotein E mediates uptake of Sf 100-400 hypertriglyceridemic very low density lipoproteins by the low density lipoprotein receptor pathway in normal human fibroblastsQ67277065
Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteinsQ70101392
Formation of cholesterol- and apoprotein E-enriched high density lipoproteins in vitroQ70257224
Conformation of T4 lysozyme in solution. Hinge-bending motion and the substrate-induced conformational transition studied by site-directed spin labelingQ72996823
A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoproteinQ73133669
The lipid-associated conformation of the low density lipoprotein receptor binding domain of human apolipoprotein EQ74037597
Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free formsQ80996400
Mapping electron paramagnetic resonance spin label conformations by the simulated scaling methodQ81467059
Apolipoprotein A-I assumes a "looped belt" conformation on reconstituted high density lipoproteinQ83337190
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectspectroscopyQ483666
P304page(s)261-271
P577publication date2008-12-24
P1433published inJournal of Molecular BiologyQ925779
P1476titleInsight on the molecular envelope of lipid-bound apolipoprotein E from electron paramagnetic resonance spectroscopy
P478volume386

Reverse relations

cites work (P2860)
Q34468854A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution.
Q30402554A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain-domain interactions
Q34497951Apolipoprotein E: From lipid transport to neurobiology
Q42005396Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4.
Q34951817Function and comorbidities of apolipoprotein e in Alzheimer's disease
Q34122180Glycosylation and sialylation of macrophage-derived human apolipoprotein E analyzed by SDS-PAGE and mass spectrometry: evidence for a novel site of glycosylation on Ser290.
Q35547011High density lipoprotein structure-function and role in reverse cholesterol transport
Q35334161Human apoE isoforms differentially regulate brain amyloid-β peptide clearance
Q57656679Lipidated apolipoprotein E4 structure and its receptor binding mechanism determined by a combined cross-linking coupled to mass spectrometry and molecular dynamics approach
Q36061394Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease
Q34559824VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation.

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