Drug targeting to brain: a systematic approach to study the factors, parameters and approaches for prediction of permeability of drugs across BBB.

scientific article published on 21 January 2013

Drug targeting to brain: a systematic approach to study the factors, parameters and approaches for prediction of permeability of drugs across BBB. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1517/17425247.2013.762354
P698PubMed publication ID23330786
P5875ResearchGate publication ID234694689

P50authorKalpana NagpalQ37828639
Shailendra Kumar SinghQ37828647
P2093author name stringDina Nath Mishra
P2860cites workTransport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormoneQ24595896
Nanotechnology: intelligent design to treat complex diseaseQ28246583
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsQ28842973
Blood-brain barrier genomicsQ33270802
Targeted delivery of paclitaxel using folate-decorated poly(lactide)-vitamin E TPGS nanoparticlesQ33327252
Phase I clinical trial and pharmacokinetic evaluation of doxorubicin carried by polyisohexylcyanoacrylate nanoparticlesQ33355908
The cell biology of the blood-brain barrier.Q33593387
Nanogels for oligonucleotide delivery to the brainQ33725062
Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles.Q33879575
Nanoparticulate systems for brain delivery of drugsQ33938252
Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain deliveryQ33955046
Astrocyte-endothelial interactions and blood-brain barrier permeabilityQ33960608
In vivo near-infrared fluorescence imagingQ33973447
How to measure drug transport across the blood-brain barrierQ33985116
Endocytosis of nanomedicines.Q33987301
Solid lipid nanoparticles for targeted brain drug deliveryQ34004708
Intraarterial chemotherapy and osmotic blood-brain barrier disruption for patients with embryonal and germ cell tumors of the central nervous systemQ34008653
Proton transport across transient single-file water pores in a lipid membrane studied by molecular dynamics simulationsQ34040267
SDS-coated atovaquone nanosuspensions show improved therapeutic efficacy against experimental acquired and reactivated toxoplasmosis by improving passage of gastrointestinal and blood-brain barriersQ44164523
UEA I-bearing nanoparticles for brain delivery following intranasal administrationQ44201223
Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturateQ44223183
Enhanced brain targeting by synthesis of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine and incorporation into solid lipid nanoparticles.Q44225181
Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticlesQ44386469
Examination of blood-brain barrier permeability in dementia of the Alzheimer type with [68Ga]EDTA and positron emission tomographyQ44529786
Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.Q45122051
Body distribution of fully biodegradable [14C]-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to ratsQ45803643
Preparation and therapeutic efficacy of polysorbate-80-coated amphotericin B/PLA-b-PEG nanoparticles.Q45923880
Brain delivery and systemic effect of cationic albumin conjugated PLGA nanoparticles.Q45968864
Unbound brain concentration determines receptor occupancy: a correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats.Q45999514
Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model.Q46033153
Nanoparticles as drug delivery agents specific for CNS: in vivo biodistributionQ46063843
The role of apolipoprotein E in uptake of atovaquone into the brain in murine acute and reactivated toxoplasmosisQ46102626
Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB).Q46355807
Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targetingQ46442643
Transport of nerve growth factor encapsulated into liposomes across the blood-brain barrier: in vitro and in vivo studiesQ46490341
Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing miceQ46514919
Intranasal nanoemulsion based brain targeting drug delivery system of risperidoneQ46612913
Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's diseaseQ46740678
Solid lipid nanoparticles of temozolomide: potential reduction of cardial and nephric toxicityQ46768039
Feedback-regulated paclitaxel delivery based on poly(N,N-dimethylaminoethyl methacrylate-co-2-hydroxyethyl methacrylate) nanoparticlesQ46768171
Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26.Q46803317
Biologically active core/shell nanoparticles self-assembled from cholesterol-terminated PEG-TAT for drug delivery across the blood-brain barrierQ46836311
Lectin-conjugated PEG-PLA nanoparticles: preparation and brain delivery after intranasal administrationQ46970487
Intrinsically fluorescent carbon nanospheres as a nuclear targeting vector: delivery of membrane-impermeable molecule to modulate gene expression in vivo.Q47341033
Efficacy of oral dalargin-loaded nanoparticle delivery across the blood-brain barrierQ47988449
Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticlesQ48003121
Targeting the central nervous system: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123.Q48096517
Development and evaluation of polymer nanoparticles for oral delivery of estradiol to rat brain in a model of Alzheimer's pathology.Q48169602
Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brainQ48208372
Rivastigmine-loaded PLGA and PBCA nanoparticles: preparation, optimization, characterization, in vitro and pharmacodynamic studies.Q42967543
Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imagingQ43074512
Evaluation of [11C]-DAA1106 for imaging and quantification of neuroinflammation in a rat model of herpes encephalitisQ43178251
Intranasal drug delivery of didanosine-loaded chitosan nanoparticles for brain targeting; an attractive route against infections caused by AIDS virusesQ43225836
Preparation and evaluation of anti-neuroexcitation peptide (ANEP) loaded N-trimethyl chitosan chloride nanoparticles for brain-targetingQ43245512
Pharmacokinetics of chlorambucil-tertiary butyl ester, a lipophilic chlorambucil derivative that achieves and maintains high concentrations in brainQ43894483
Transport of stavudine, delavirdine, and saquinavir across the blood-brain barrier by polybutylcyanoacrylate, methylmethacrylate-sulfopropylmethacrylate, and solid lipid nanoparticlesQ48211150
1-O-alkylglycerol stabilized carbamazepine intravenous o/w nanoemulsions for drug targeting in miceQ48238599
Nanoparticle mediated brain targeted delivery of gallic acid: in vivo behavioral and biochemical studies for improved antioxidant and antidepressant-like activityQ48284169
Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolismQ48356189
Lactoferrin-modified nanoparticles could mediate efficient gene delivery to the brain in vivoQ48372285
Tight-junctional modification as the basis of osmotic opening of the blood-brain barrierQ48408807
Phospholipid based colloidal poloxamer-nanocubic vesicles for brain targeting via the nasal route.Q48450160
Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimerQ48455152
The brain targeting efficiency following nasally applied MPEG-PLA nanoparticles in ratsQ48457386
Side by side comparison between dynamic versus static models of blood-brain barrier in vitro: a permeability studyQ48466858
Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrierQ48520343
Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: an in situ brain perfusion studyQ48536446
Delivery of hydrophobised 5-fluorouracil derivative to brain tissue through intravenous route using surface modified nanogelsQ48587261
Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticlesQ48589259
Covalent linkage of apolipoprotein e to albumin nanoparticles strongly enhances drug transport into the brain.Q48608387
Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neuronesQ48706032
Baicalein loaded in tocol nanostructured lipid carriers (tocol NLCs) for enhanced stability and brain targetingQ48758897
Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrierQ48774664
Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles.Q48784173
BBB-Genomics: creating new openings for brain-drug targetingQ48919251
Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain deliveryQ49058125
The first step into the brain: uptake of NIO-PBCA nanoparticles by endothelial cells in vitro and in vivo, and direct evidence for their blood-brain barrier permeationQ49106787
Nanoparticles, a drug carrier system to pass the blood-brain barrier, permit central analgesic effects of i.v. dalargin injectionsQ49111527
Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrierQ49270919
The formulation, characterization and in vivo evaluation of a magnetic carrier for brain delivery of NIR dye.Q50541826
The association of silicon microparticles with endothelial cells in drug delivery to the vasculature.Q51822661
Transport of Poly(n-butylcyano-acrylate) nanoparticles across the blood-brain barrier in vitro and their influence on barrier integrity.Q52607718
Influence of surface-modifying surfactants on the pharmacokinetic behavior of 14C-poly (methylmethacrylate) nanoparticles in experimental tumor models.Q52960129
Why is the global CNS pharmaceutical market so under-penetrated?Q55035622
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsQ57001954
Log(BB), PS products and in silico models of drug brain penetrationQ57677352
Body distribution of azidothymidine bound to hexyl-cyanoacrylate nanoparticles after i.v. injection to ratsQ59237516
Measurement of brain uptake of radiolabeled substances using a tritiated water internal standardQ34053885
A method to determine the ability of drugs to diffuse through the blood-brain barrierQ34061126
Role of the CNS microvascular pericyte in the blood-brain barrierQ34067528
Blood-brain barrier permeation: molecular parameters governing passive diffusionQ34067620
Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brainQ34124710
Lipophilicity in PK design: methyl, ethyl, futileQ34209458
Adenosine receptor signaling modulates permeability of the blood-brain barrier.Q34216355
Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targetingQ34258878
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplificationQ34350623
Visualization of exogenous delivery of nanoformulated butyrylcholinesterase to the central nervous systemQ34388647
Double-coated poly (butylcynanoacrylate) nanoparticulate delivery systems for brain targeting of dalargin via oral administrationQ34414515
Molecular imprinting within hydrogelsQ34470016
Apolipoprotein E: From lipid transport to neurobiologyQ34497951
Permeability of the blood-brain barrier for atenolol studied by positron emission tomographyQ34543317
Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells.Q34708980
Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cellsQ35003095
Venlafaxine loaded chitosan NPs for brain targeting: pharmacokinetic and pharmacodynamic evaluationQ35153612
Molecular mechanism of endothelial growth arrest by laminar shear stressQ35205740
Hard and soft micromachining for BioMEMS: review of techniques and examples of applications in microfluidics and drug deliveryQ35637324
A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicityQ35660849
Is nose-to-brain transport of drugs in man a reality?Q35673938
In vitro blood-brain barrier models: current and perspective technologiesQ35782792
Novel strategic therapeutic approaches for prevention of local recurrence of pancreatic cancer after resection: trans-tissue, sustained local drug-delivery systemsQ35965296
Astrocytes: regulation of brain homeostasis via apolipoprotein E.Q36075053
A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrierQ36267668
The use of monolayers for simple and quantitative analysis of lipid-drug interactions exemplified with dibucaine and substance PQ36580365
Fluorescence imaging in vivo: recent advancesQ36711843
Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular deliveryQ36773586
On the rate and extent of drug delivery to the brain.Q37023904
Strategies to advance translational research into brain barriersQ37037950
Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathyQ37154213
PE2I: a radiopharmaceutical for in vivo exploration of the dopamine transporterQ37164698
Intranasal mucoadhesive microemulsion of tacrine to improve brain targetingQ37182367
Progress in drug delivery to the central nervous system by the prodrug approach.Q37193593
Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS.Q37395149
Challenges and opportunities in CNS delivery of therapeutics for neurodegenerative diseasesQ37416147
Gum arabic-coated magnetic nanoparticles for potential application in simultaneous magnetic targeting and tumor imagingQ37433524
Nanoparticles for direct nose-to-brain delivery of drugs.Q37531152
Brain drug targeting: a computational approach for overcoming blood-brain barrierQ37568584
Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseasesQ37576225
Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new conceptQ37638537
Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dotsQ37668250
Quinoline-n-butylcyanoacrylate-based nanoparticles for brain targeting for the diagnosis of Alzheimer's diseaseQ37668424
In vitro blood-brain barrier models--latest advances and therapeutic applications in a chronological perspective.Q37735241
Strategy for effective brain drug delivery.Q37760347
In vivo methods to study uptake of nanoparticles into the brain.Q37798178
Transport of drugs across the blood-brain barrier by nanoparticles.Q37923068
Nanotechnological advances for the delivery of CNS therapeuticsQ37958426
Modern methods for delivery of drugs across the blood-brain barrierQ37966443
Opportunities in systems biology to discover mechanisms and repurpose drugs for CNS diseasesQ38023097
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse modelQ38448723
Solid lipid nanoparticles as intracellular drug transporters: an investigation of the uptake mechanism and pathway.Q39371382
The transport of non-surfactant based paclitaxel loaded magnetic nanoparticles across the blood brain barrier in a rat model.Q39408907
Improved transnasal transport and brain uptake of tizanidine HCl-loaded thiolated chitosan nanoparticles for alleviation of pain.Q39456726
The brain targeting mechanism of Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticlesQ39680497
Enhanced efficacy of functionalized epirubicin liposomes in treating brain glioma-bearing ratsQ39684569
Evaluation of O-[(18)F]fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomographyQ39867815
Lactoferrin-modified procationic liposomes as a novel drug carrier for brain deliveryQ39890616
Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injuryQ39942829
Three-step tumor targeting of paclitaxel using biotinylated PLA-PEG nanoparticles and avidin-biotin technology: Formulation development and in vitro anticancer activityQ39972148
Cytotoxicity and apoptosis enhancement in brain tumor cells upon coadministration of paclitaxel and ceramide in nanoemulsion formulationsQ40081472
Characterization and magnetic resonance imaging of a rat model of human B-cell central nervous system lymphomaQ40145038
Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathwayQ40340698
Animal models for studying transport across the blood-brain barrierQ40506058
Paclitaxel nanoparticles for the potential treatment of brain tumorsQ40513384
Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.Q40639360
Predicting blood-brain barrier permeability of drugs: evaluation of different in vitro assaysQ40712615
Magnetic targeting of nanoparticles across the intact blood-brain barrierQ40954233
Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations.Q42108498
Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticlesQ42458746
Relationship between permeability status of the blood-brain barrier and in vitro permeability coefficient of a drugQ42496777
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)927-955
P577publication date2013-01-21
P1433published inExpert Opinion on Drug DeliveryQ5421203
P1476titleDrug targeting to brain: a systematic approach to study the factors, parameters and approaches for prediction of permeability of drugs across BBB.
P478volume10

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cites work (P2860)
Q48818624A Comparative Study of Orally Delivered PBCA and ApoE Coupled BSA Nanoparticles for Brain Targeting of Sumatriptan Succinate in Therapeutic Management of Migraine
Q36172940A Genetic Algorithm Based Support Vector Machine Model for Blood-Brain Barrier Penetration Prediction
Q38243893Activators of AMPK: not just for type II diabetes
Q38836486Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery
Q64997828Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood-brain barrier transport.
Q88128137Improved Prediction of Blood-Brain Barrier Permeability Through Machine Learning with Combined Use of Molecular Property-Based Descriptors and Fingerprints
Q38700355In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans
Q48870977Influence of the formulation on the maximum tolerated doses of brain targeted nanoparticles of gallic acid by oral administration in Wistar rats
Q57570763Nanoparticle Functionalization for Brain Targeting Drug Delivery and Diagnostic
Q37698620Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system
Q28540914P-glycoprotein mediated efflux limits the transport of the novel anti-Parkinson's disease candidate drug FLZ across the physiological and PD pathological in vitro BBB models
Q36020685Poly(lactic-co-glycolic) Acid-Chitosan Dual Loaded Nanoparticles for Antiretroviral Nanoformulations
Q92798768Recent expansions of novel strategies towards the drug targeting into the brain
Q44106992Targeted delivery of drugs to the brain.

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