Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels.

scientific article published on 14 February 2013

Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/ATVBAHA.112.301193
P932PMC publication ID3660844
P698PubMed publication ID23413428
P5875ResearchGate publication ID235630616

P50authorMichael C. PhillipsQ41206886
P2093author name stringHui Li
Daniel J Rader
Padmaja Dhanasekaran
Sissel Lund-Katz
Eric T Alexander
P2860cites workThe C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteinsQ24297456
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Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single siteQ28264429
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cellsQ28509783
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein EQ29615236
Apo E structure determines VLDL clearance and atherosclerosis risk in mice.Q30322098
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.Q33769359
Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins.Q34331138
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Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer.Q35689481
Formation of high density lipoprotein2-like particles during lipolysis of very low density lipoproteins in vitroQ35991748
ApoE gene therapy to treat hyperlipidemia and atherosclerosisQ36586704
Apolipoprotein E: structure-function relationshipsQ40737965
Gene therapy for atherosclerosisQ41465066
Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I.Q41571954
Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related proteinQ41709963
Influence of apolipoprotein A-I domain structure on macrophage reverse cholesterol transport in miceQ41952869
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Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wallQ42019558
Molecular basis for the differences in lipid and lipoprotein binding properties of human apolipoproteins E3 and E4.Q42173611
Contributions of the carboxyl-terminal helical segment to the self-association and lipoprotein preferences of human apolipoprotein E3 and E4 isoformsQ42173744
Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein E in a dose-dependent mannerQ42252844
Molecular mechanism of apolipoprotein E binding to lipoprotein particlesQ42589582
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LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in miceQ43916892
Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease.Q44189963
Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8.Q45415785
Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domainQ46175909
Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemiaQ46345830
Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.Q46740358
Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo.Q51580953
Markedly increased secretion of VLDL triglycerides induced by gene transfer of apolipoprotein E isoforms in apoE-deficient miceQ64380964
Apolipoprotein E polymorphism and atherosclerosisQ68126635
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)687-693
P577publication date2013-02-14
P1433published inArteriosclerosis, Thrombosis, and Vascular BiologyQ4797542
P1476titleMolecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels
P478volume33

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cites work (P2860)
Q33789429APOE gene polymorphism in long-lived individuals from a central China population
Q36843340ApoE knockout and knockin mice: the history of their contribution to the understanding of atherogenesis
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Q26747482Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders
Q41036900Apolipoprotein ε7 allele in memory complaints: insights through protein structure prediction
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Q89841154Beyond the CNS: The many peripheral roles of APOE
Q36185793Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins
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Q36836880Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II.
Q42174067Fluorescence study of domain structure and lipid interaction of human apolipoproteins E3 and E4.
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Q58783963In the Heart of the Amazon: Noncommunicable Diseases and Apolipoprotein E4 Genotype in the Riverine Population
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