scholarly article | Q13442814 |
P356 | DOI | 10.2174/15672050113109990156 |
P8608 | Fatcat ID | release_j32clc5ilrhy5fgnpwmickt7ee |
P932 | PMC publication ID | 3995977 |
P698 | PubMed publication ID | 23919769 |
P50 | author | Robert O. Ryan | Q57668754 |
P2093 | author name string | Paul S Hauser | |
P2860 | cites work | Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease | Q22248091 |
Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity | Q24291110 | ||
Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation | Q24291128 | ||
The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins | Q24297456 | ||
The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motif | Q24600203 | ||
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models | Q24628845 | ||
ApoE promotes the proteolytic degradation of Abeta | Q24651102 | ||
Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease | Q26858870 | ||
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E | Q27663468 | ||
Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions | Q27672294 | ||
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms | Q27730887 | ||
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families | Q27860677 | ||
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics | Q27860914 | ||
ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins | Q28140079 | ||
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease | Q28238269 | ||
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease | Q28294536 | ||
Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain | Q28477020 | ||
LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins | Q28595076 | ||
Isoform-specific binding of apolipoprotein E to beta-amyloid | Q28596589 | ||
Decreased clearance of CNS beta-amyloid in Alzheimer's disease | Q29616534 | ||
Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice | Q30486146 | ||
ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice | Q30497102 | ||
Human apolipoprotein A-I binds amyloid-beta and prevents Abeta-induced neurotoxicity | Q33398425 | ||
Molecular basis of exchangeable apolipoprotein function | Q33796767 | ||
Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice | Q33906674 | ||
Lipoproteins in the central nervous system | Q33922696 | ||
Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. | Q34096644 | ||
Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3 | Q34229659 | ||
Apolipoprotein E: From lipid transport to neurobiology | Q34497951 | ||
Abnormal in vivo metabolism of apolipoprotein E4 in humans | Q34539465 | ||
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. | Q44989710 | ||
Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide | Q45738154 | ||
Lipid-induced extension of apolipoprotein E helix 4 correlates with low density lipoprotein receptor binding ability. | Q45930842 | ||
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. | Q45993868 | ||
Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE. | Q46001228 | ||
Interaction with amyloid beta peptide compromises the lipid binding function of apolipoprotein E. | Q46067044 | ||
Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels | Q46262337 | ||
Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains | Q46421943 | ||
Fluorescence resonance energy transfer analysis of apolipoprotein E C-terminal domain and amyloid beta peptide (1-42) interaction | Q46478601 | ||
Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins | Q46656933 | ||
The structure of human apolipoprotein E2, E3 and E4 in solution 1. Tertiary and quaternary structure. | Q46684770 | ||
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. | Q46738144 | ||
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease | Q46738145 | ||
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice | Q46738149 | ||
Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112. | Q46740358 | ||
Medicine. Old drug, new hope for Alzheimer's disease | Q47570227 | ||
Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse | Q48024701 | ||
Apolipoprotein E and Alzheimer's disease. The tip of the susceptibility iceberg | Q48293119 | ||
Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease | Q49168963 | ||
Molecular dynamics simulation and computational two-dimensional infrared spectroscopic study of model amyloid β-peptide oligomers. | Q51021433 | ||
Protective effect of apoE epsilon 2 in Alzheimer's disease. | Q53314590 | ||
Lipid binding-induced conformational changes in the N-terminal domain of human apolipoprotein E. | Q53940110 | ||
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins | Q68921833 | ||
The low density lipoprotein receptor active conformation of apolipoprotein E. Helix organization in n-terminal domain-phospholipid disc particles | Q77332976 | ||
Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms | Q80996400 | ||
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease | Q34662682 | ||
Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease | Q34960461 | ||
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease | Q35084110 | ||
An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia | Q35152189 | ||
Nuclear receptors as therapeutic targets for Alzheimer's disease | Q35165186 | ||
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice | Q35978742 | ||
Purified and synthetic Alzheimer's amyloid beta (Aβ) prions | Q36079533 | ||
Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice | Q36206696 | ||
Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease | Q36208400 | ||
Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition | Q36304858 | ||
Assembly of high-density lipoprotein | Q36311786 | ||
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. | Q36383616 | ||
Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide | Q36384642 | ||
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. | Q36451896 | ||
The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration | Q37017266 | ||
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons | Q37117670 | ||
PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease | Q37215869 | ||
Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure | Q37307244 | ||
Greasing the wheels of Abeta clearance in Alzheimer's disease: the role of lipids and apolipoprotein E. | Q37497056 | ||
Clusterin: a forgotten player in Alzheimer's disease | Q37570713 | ||
Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches | Q37623844 | ||
Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease | Q37676477 | ||
Clusterin in Alzheimer's disease | Q37991343 | ||
Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions | Q38353402 | ||
Preventing Alzheimer's disease | Q39549596 | ||
Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease | Q39625718 | ||
24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression | Q40209163 | ||
Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis | Q40374258 | ||
Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer | Q40571686 | ||
A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes | Q40599853 | ||
Apolipoprotein E: structure-function relationships | Q40737965 | ||
The amphipathic alpha helix: a multifunctional structural motif in plasma apolipoproteins | Q40737971 | ||
Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease | Q40849918 | ||
Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides | Q40879124 | ||
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. | Q41671941 | ||
Cell biology. A unifying role for prions in neurodegenerative diseases | Q41997625 | ||
Lipid association-induced N- and C-terminal domain reorganization in human apolipoprotein E3. | Q43694392 | ||
Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice | Q43752025 | ||
Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model | Q44412885 | ||
Reduced levels of human apoE4 protein in an animal model of cognitive impairment | Q44601281 | ||
Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles | Q44739118 | ||
Transformation of amyloid β(1-40) oligomers into fibrils is characterized by a major change in secondary structure | Q44808414 | ||
P433 | issue | 8 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Alzheimer's disease | Q11081 |
P304 | page(s) | 809-17 | |
P577 | publication date | 2013-10-01 | |
P1433 | published in | Current Alzheimer Research | Q5195031 |
P1476 | title | Impact of apolipoprotein E on Alzheimer's disease | |
P478 | volume | 10 |
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