Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer's disease

scientific article published on 05 October 2018

Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1096/FJ.201801412R
P932PMC publication ID6338661
P698PubMed publication ID30289748

P50authorDr. Rhonda PatrickQ109301171
P2860cites workEffect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretionQ48775504
(n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in ratsQ48788625
APOE ε4 differentially influences change in memory performance depending on age. The SMART-MR studyQ48906484
Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis.Q51053469
Blood compartmental metabolism of docosahexaenoic acid (DHA) in humans after ingestion of a single dose of [(13)C]DHA in phosphatidylcholine.Q51646100
Intelligence and event-related potentials for young female human volunteer apolipoprotein E epsilon4 and non-epsilon4 carriers.Q53238833
Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4.Q53273541
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Alzheimer's diseaseQ60313667
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Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trialQ24607545
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Elucidation of phosphatidylcholine composition in krill oil extracted from Euphausia superbaQ24634419
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Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acidQ28115048
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis ConsortiumQ28252389
Better memory and neural efficiency in young apolipoprotein E epsilon4 carriersQ28271343
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Interactive effects of physical activity and APOE-ε4 on BOLD semantic memory activation in healthy eldersQ28384123
Mfsd2a is critical for the formation and function of the blood-brain barrierQ28507996
Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdownQ33717021
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.Q33717326
Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older AdultsQ33768448
Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brainQ34322444
Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain.Q34322455
O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's diseaseQ34333004
Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older PersonsQ34354571
Reversal of cognitive decline: a novel therapeutic programQ34461143
Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndromeQ34477725
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Dietary patterns and risk of dementia: the Three-City cohort study.Q34584817
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Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in miceQ34976193
Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier modelQ34978900
Blood-brain barrier breakdown in the aging human hippocampusQ35151019
Metabolic profiling distinguishes three subtypes of Alzheimer's diseaseQ36100673
Phospholipid and fatty acid specificity of endothelial lipase: potential role of the enzyme in the delivery of docosahexaenoic acid (DHA) to tissuesQ36168147
Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.Q36455090
Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer diseaseQ36468141
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GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degenerationQ36526013
Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's diseaseQ36615510
Structural Insights into the Transport Mechanism of the Human Sodium-dependent Lysophosphatidylcholine Transporter MFSD2A.Q36849973
The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid compositionQ37006519
Enhanced incorporation of dietary DHA into lymph phospholipids by altering its molecular carrierQ37015178
The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's diseaseQ37054938
Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based studyQ37310717
Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleepQ37384609
Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal pigletsQ37603235
The use of PET in Alzheimer diseaseQ37688880
DHA may prevent age-related dementiaQ37698014
Plasma phospholipids identify antecedent memory impairment in older adults.Q37714213
Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease.Q37734864
ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?Q38190156
Biological properties of a DHA-containing structured phospholipid (AceDoPC) to target the brain.Q38192243
2015 Alzheimer's disease facts and figuresQ40928952
Microglia function in Alzheimer's diseaseQ41014561
Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice.Q41193473
Regulation of the plasma non-esterified fatty acid concentration in the postprandial stateQ41571831
A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndromeQ41928079
Structural elucidation of molecular species of pacific oyster ether amino phospholipids by normal-phase liquid chromatography/negative-ion electrospray ionization and quadrupole/multiple-stage linear ion-trap mass spectrometryQ42205596
Positional Distribution of Fatty Acids in Triacylglycerols and Phospholipids from Fillets of Atlantic Salmon (Salmo Salar) Fed Vegetable and Fish Oil Blends.Q42391686
Reversal of cognitive decline in Alzheimer's diseaseQ42433808
n-3 Fatty acids modulate brain glucose transport in endothelial cells of the blood-brain barrierQ42521884
Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells.Q42547641
Bioavailability of marine n-3 fatty acid formulationsQ42967046
Glucose transport and utilization are altered in the brain of rats deficient in n-3 polyunsaturated fatty acids.Q44030470
Regioisomers of phosphatidylcholine containing DHA and their potential to deliver DHA to the brain: role of phospholipase specificitiesQ44965942
Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study.Q46011960
Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.Q46019370
Dietary alpha-linolenic acid and health-related outcomes: a metabolic perspective.Q46200000
Comparison of molecular species of various transphosphatidylated phosphatidylserine (PS) with bovine cortex PS by mass spectrometryQ46784547
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.Q46786077
DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trialQ48117600
Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease.Q48126715
Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart StudyQ48371548
Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4.Q48376822
Effect of APOE genotype on microvascular basement membrane in Alzheimer's diseaseQ48453732
Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fastingQ48573957
GLUT-1 expression in the cerebra of patients with Alzheimer's diseaseQ48589517
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivativesQ6937225
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
phosphatidylcholineQ650187
P304page(s)1554-1564
P577publication date2018-10-05
2019-02-01
P1433published inFASEB JournalQ520194
P1476titleRole of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer's disease
P478volume33

Reverse relations

Q64244953Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formationcites workP2860

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