Effects of Methylation Status of CpG Sites within the HPV16 Long Control Region on HPV16-Positive Head and Neck Cancer Cells

scientific article published on 28 October 2015

Effects of Methylation Status of CpG Sites within the HPV16 Long Control Region on HPV16-Positive Head and Neck Cancer Cells is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1041245Z
P356DOI10.1371/JOURNAL.PONE.0141245
P932PMC publication ID4625038
P698PubMed publication ID26509736
P5875ResearchGate publication ID283305485

P50authorZeyi DengQ51759372
P2093author name stringChunlin Zhang
Xiaoli Pan
Mikio Suzuki
Minqiang Xie
Takayuki Uehara
P2860cites workQuantitation of site-specific HPV 16 DNA methylation by pyrosequencingQ40219565
Interaction of the papillomavirus E2 protein with mitotic chromosomesQ40885434
Prevalence of human papillomavirus in oropharyngeal cancer: a multicenter study in Japan.Q42205751
Cellular differentiation, cytidine analogs and DNA methylationQ42242732
Pharmacokinetic and pharmacodynamic analysis of 5-aza-2'-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy.Q43247519
Lack of association of alcohol and tobacco with HPV16-associated head and neck cancerQ43428716
Viral load, physical status, and E6/E7 mRNA expression of human papillomavirus in head and neck squamous cell carcinomaQ43436601
CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2.Q43785734
Mutations in the long control region of human papillomavirus DNA in oral cancer cells, and their functional consequences.Q45128453
Human papillomavirus-16 DNA methylation patterns support a causal association of the virus with oral squamous cell carcinomasQ45407529
Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cellsQ47652127
Methylation status of the E2 binding sites of HPV16 in cervical lesions determined with the Luminex® xMAP™ system.Q53278101
The effect of DNA methylation on gene regulation of human papillomavirusesQ53480634
Cell cycle effects and cellular pharmacology of 5-AZA-2?-deoxycytidineQ54485278
The fundamental role of epigenetic events in cancerQ56421597
Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynxQ58226228
Cellular transcription factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognized by the viral E2 proteinQ78191913
Prognostic value of human papillomavirus and squamous cell carcinoma antigen in head and neck squamous cell carcinomaQ84908977
Methylation of HPV16 genome CpG sites is associated with cervix precancer and cancerQ24633086
Worms gang up on bacteriaQ27860588
Case-control study of human papillomavirus and oropharyngeal cancerQ28301695
Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomasQ30783406
Evidence for a causal association between human papillomavirus and a subset of head and neck cancersQ33180284
Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral originsQ33611284
The chromatin structure of the long control region of human papillomavirus type 16 represses viral oncoprotein expression.Q33652913
Abrogation of a mitotic checkpoint by E2 proteins from oncogenic human papillomaviruses correlates with increased turnover of the p53 tumor suppressor protein.Q33886001
Differential Methylation of the HPV 16 Upstream Regulatory Region during Epithelial Differentiation and Neoplastic TransformationQ34019049
Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 ExpressionsQ34412697
Epstein-Barr virus and human papillomavirus infections and genotype distribution in head and neck cancersQ34535924
E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell deathQ34647460
Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathwaysQ34676199
Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer.Q34680748
Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancersQ34760882
Characterization of the Methylation Patterns in Human Papillomavirus Type 16 Viral DNA in Head and Neck CancersQ34813512
CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progressionQ34996306
Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expressionQ35106230
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell linesQ35796373
Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathwaysQ35815917
Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylationQ35939534
The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytesQ36831207
Effects of cellular differentiation, chromosomal integration and 5-aza-2'-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured cell linesQ36914963
Methylation Patterns of Papillomavirus DNA, Its Influence on E2 Function, and Implications in Viral InfectionQ37060103
Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells.Q37094001
The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancerQ37142007
Long-term prognosis and risk factors among patients with HPV-associated oropharyngeal squamous cell carcinomaQ37209937
Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinomaQ37343877
Human papillomavirus-16 and -18 in penile carcinomas: DNA methylation, chromosomal recombination and genomic variationQ37361262
Integrated virus-host methylome analysis in head and neck squamous cell carcinoma.Q37445239
Detection of HPV16 African variants and quantitative analysis of viral DNA methylation in oropharyngeal squamous cell carcinomasQ38993326
Star-shaped cyclodextrin-poly(l-lysine) derivative co-delivering docetaxel and MMP-9 siRNA plasmid in cancer therapyQ39028314
Prevalence and clinical features of human papillomavirus in head and neck squamous cell carcinoma in Okinawa, southern JapanQ39590690
Methylation of the long control region of HPV16 is related to the severity of cervical neoplasiaQ39789073
E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cellsQ39874615
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecthead and neck cancerQ1783924
head and neck carcinomaQ18554836
neck cancerQ18966654
P304page(s)e0141245
P577publication date2015-10-28
P1433published inPLOS OneQ564954
P1476titleEffects of Methylation Status of CpG Sites within the HPV16 Long Control Region on HPV16-Positive Head and Neck Cancer Cells
P478volume10

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cites work (P2860)
Q406515975-aza-2'-deoxycytidine (DAC) treatment downregulates the HPV E6 and E7 oncogene expression and blocks neoplastic growth of HPV-associated cancer cells
Q92383081DNA demethylation agent 5azadC downregulates HPV16 E6 expression in cervical cancer cell lines independently of TBX2 expression
Q47397458Down-regulation of p16 and MGMT promotes the anti-proliferative and pro-apoptotic effects of 5-Aza-dC and radiation on cervical cancer cells.
Q47131449Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors
Q30392430Recent advances in universal TA cloning methods for use in function studies.

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