Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone

scientific article published in March 2006

Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2125.2005.02567.X
P932PMC publication ID1885012
P698PubMed publication ID16487222
P5875ResearchGate publication ID7290355

P50authorDyfrig A. HughesQ40943753
Kalifa A BojangQ42305767
Julie A. SimpsonQ47172274
Steve WardQ55112735
Christine ManyandoQ85982640
P2093author name stringLeon Aarons
Peter Winstanley
Geoffrey Edwards
William A Watkins
P2860cites workDevelopmental aspects of human hepatic drug glucuronidation in young children and adultsQ28344957
Severe falciparum malaria. World Health Organization, Communicable Diseases ClusterQ29614923
Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant population.Q33749505
Pharmacokinetics of dapsone administered daily and weekly in human immunodeficiency virus-infected childrenQ33977967
Nonlinear mixed effects models for repeated measures dataQ34198168
How can we do pharmacokinetic studies in the tropics?Q34387231
The disposition of oral and intramuscular pyrimethamine/sulphadoxine in Kenyan children with high parasitaemia but clinically non-severe falciparum malariaQ34402882
Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malariaQ37739425
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trialQ38870092
The efficacy of antimalarial monotherapies, sulphadoxine–pyrimethamine and amodiaquine in East Africa: implications for sub‐regional policyQ38882717
The search for synergy: a critical review from a response surface perspective.Q40417895
Pharmacokinetics of chlorproguanil in man after a single oral dose of LapudrineQ41912638
The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analysesQ41913682
Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sitesQ43409079
Population pharmacokinetics of dapsone in children with human immunodeficiency virus infectionQ43673163
Plasma, erythrocyte and urine concentrations of chlorproguanil and two metabolites in man after different dosesQ45040293
Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic rangeQ46154949
A preliminary pharmacokinetic study of the antimalarial drugs, proguanil and chlorproguanilQ47900426
Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymesQ73846452
All-trans-retinoic acid modulation of drug-metabolizing enzyme activities: investigation with selective metabolic drug probesQ74094338
Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteinsQ77228680
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
antimalarialQ521616
pharmacodynamicsQ725307
chemotherapyQ974135
P304page(s)289-300
P577publication date2006-03-01
P1433published inBritish Journal of Clinical PharmacologyQ176044
P1476titlePopulation pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone
P478volume61

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cites work (P2860)
Q28477853A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial
Q21143739Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria
Q28473083Duration of protection against clinical malaria provided by three regimens of intermittent preventive treatment in Tanzanian infants
Q33726415Formation and identification of a degradant in chlorproguanil–dapsone–artesunate (Dacart™) tablets
Q36832446Malaria chemotherapeutics part I: History of antimalarial drug development, currently used therapeutics, and drugs in clinical development
Q37207985Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants
Q28534820Nonlinear mixed-effects modelling of in vitro drug susceptibility and molecular correlates of multidrug resistant Plasmodium falciparum
Q26830528Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization
Q37257896Pharmacokinetics and pharmacodynamics in the development of anti-tuberculosis drugs
Q45973898Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.
Q46990184Population pharmacokinetics of valproate in Chinese children with epilepsy
Q40187269Supervised Machine-Learning Reveals That Old and Obese People Achieve Low Dapsone Concentrations
Q34894294The effect of intermittent preventive treatment on anti-malarial drug resistance spread in areas with population movement

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