In vitro and in vivo studies on the generation of the primary T-cell receptor repertoire

scientific article published in August 2004

In vitro and in vivo studies on the generation of the primary T-cell receptor repertoire is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.0105-2896.2004.00170.X
P8608Fatcat IDrelease_xg7y3bconnckjg2kzntgrwssgi
P698PubMed publication ID15242393

P2093author name stringFerenc Livák
P2860cites workWhy PLoS became a publisherQ21146442
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombinationQ24294409
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray dosesQ24677973
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AXQ28139663
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damageQ28144576
The RAG proteins and V(D)J recombination: complexes, ends, and transpositionQ28145648
ATM phosphorylates histone H2AX in response to DNA double-strand breaksQ28188651
Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AXQ28191330
Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombinationQ28275539
RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombinationQ28307236
Genomic instability in mice lacking histone H2AXQ28589826
RAG-1-deficient mice have no mature B and T lymphocytesQ28592133
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangementQ28594711
Evolution of the recombination signal sequences in the Ig heavy-chain variable region locus of mammalsQ28776622
Somatic generation of antibody diversityQ29616439
High mobility of proteins in the mammalian cell nucleusQ29616460
Atm-deficient mice: a paradigm of ataxia telangiectasiaQ29619532
DNA hairpin opening mediated by the RAG1 and RAG2 proteinsQ33652023
Structural basis of T cell recognitionQ33652495
Chromosomal breakage syndromesQ33711443
Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequencesQ33775546
RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complexQ33958065
Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linkingQ33958242
Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombinationQ33960582
Postcleavage sequence specificity in V(D)J recombinationQ33964568
The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombinationQ33966875
RAG transposase can capture and commit to target DNA before or after donor cleavageQ33968578
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AXQ34031720
Ordered assembly of the V(D)J synaptic complex ensures accurate recombinationQ34090070
Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunityQ34098891
Spatial and temporal cellular responses to single-strand breaks in human cells.Q34197035
Assembly of the RAG1/RAG2 synaptic complexQ34290414
The MHC reactivity of the T cell repertoire prior to positive and negative selection.Q34418401
The mechanism and regulation of chromosomal V(D)J recombinationQ34619795
V(D)J recombination: RAG proteins, repair factors, and regulationQ34667417
Interfaces between the detection, signaling, and repair of DNA damageQ34762844
Sensing of intermediates in V(D)J recombination by ATM.Q35005088
Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segmentsQ35173467
Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient miceQ35795447
In vitro V(D)J recombination: signal joint formationQ35940601
Transient restoration of gene rearrangement at multiple T cell receptor loci in gamma-irradiated scid miceQ36367068
Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaksQ36368896
Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modelingQ36370482
Genetic modulation of T cell receptor gene segment usage during somatic recombinationQ36376045
How many thymocytes audition for selection?Q36380676
Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vkappa usage in vivoQ36400779
H2AX haploinsufficiency modifies genomic stability and tumor susceptibilityQ36533572
rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependentQ36555390
T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cellsQ36557127
Cryptic signals and the fidelity of V(D)J joiningQ36568596
Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells.Q38296131
The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoireQ38307676
Hairpin coding end opening is mediated by RAG1 and RAG2 proteinsQ38329558
V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.Q38334568
Structure of nonhairpin coding-end DNA breaks in cells undergoing V(D)J recombinationQ39631050
Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repairQ39674379
The role of components of recombination signal sequences in immunoglobulin gene segment usage: a V81x model.Q39729937
DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent mannerQ40315391
New insights into V(D)J recombination and its role in the evolution of the immune systemQ40429013
The B12/23 restriction is critically dependent on recombination signal nonamer and spacer sequencesQ40609333
DNA-Rag Protein Interactions in the Control of Selective D Gene Utilization in the TCRβ LocusQ40633187
The kinetics of V-J joining throughout 3.5 megabases of the mouse Ig kappa locus fit a constrained diffusion model of nuclear organizationQ40670837
Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.Q40874673
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune systemQ41011364
Identification of V(D)J recombination coding end intermediates in normal thymocytesQ41120267
RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombinationQ41157754
Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitroQ41191663
Initiation of V(D)J recombination in vitro obeying the 12/23 ruleQ41218012
Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursorsQ41512971
Extent to which homology can constrain coding exon junctional diversity in V(D)J recombinationQ41547272
The cleavage efficiency of the human immunoglobulin heavy chain VH elements by the RAG complex: implications for the immune repertoireQ43470902
T-cell receptor delta gene rearrangements in early thymocytesQ46048219
Differential transcriptional regulation of individual TCR V beta segments before gene rearrangementQ46862481
V(D)J Recombination Frequencies Can Be Profoundly Affected by Changes in the Spacer SequenceQ47395217
Recombination signal sequence variations and the mechanism of patterned T-cell receptor-beta locus rearrangementQ47714121
DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocationsQ47750695
Evolutionarily conserved pattern of gene segment usage within the mammalian TCRbeta locusQ47779893
The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombinationQ48313594
Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two stepsQ49167454
Rejoining of DNA by the RAG1 and RAG2 proteinsQ49172612
Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.Q51840167
Cutting edge: targeting of V beta to D beta rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors.Q51840746
Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.Q52244112
Chromosomal translocations in human cancer.Q52512616
Biased V beta usage in immature thymocytes is independent of DJ beta proximity and pT alpha pairing.Q52927147
Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence.Q54159375
Rapid identification of local T cell expansion in inflammatory organ diseases by flow cytometric T cell receptor Vβ analysisQ58880326
P304page(s)23-35
P577publication date2004-08-01
P1433published inImmunological ReviewsQ15724582
P1476titleIn vitro and in vivo studies on the generation of the primary T-cell receptor repertoire
P478volume200

Reverse relations

Q34722732ATM and the Mre11 complex combine to recognize and signal DNA double-strand breakscites workP2860

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