Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene

scientific article published on 12 March 2007

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2006-06-029173
P932PMC publication ID1890824
P698PubMed publication ID17353346

P50authorSteven RosenbergQ2347448
P2093author name stringDavid J Munroe
Thomas Ried
Paul F Robbins
Cynthia E Dunbar
Kenneth Cornetta
Claudia Stewart
Richard A Morgan
Zhili Zheng
Peter D Peng
Juhua Zhou
Cyrille J Cohen
Danny Wangsa
Cary Hsu
Xinglei Shen
Stephanie A Jones
Keith Kerstann
Theotonius J Gomes
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Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry.Q55067752
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IL-15 activates telomerase and minimizes telomere loss and may preserve the replicative life span of memory CD8+ T cells in vitroQ81546505
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsQ27860926
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1Q28210584
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Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy.Q34314036
Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.Q34334845
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Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawal-induced apoptosis and persist long-term in the absence of exogenous cytokineQ34657676
Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functionsQ34669675
Focus on acute leukemiasQ34747215
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Gene Therapy Targeting Hematopoietic Cells: Better Not Leave It to ChanceQ35570283
Chance or necessity? Insertional mutagenesis in gene therapy and its consequencesQ35637501
Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaqueQ35848273
Forkhead transcription factors in immunology.Q36047235
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Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stabilityQ36286127
Survival of the fittest: in vivo selection and stem cell gene therapyQ36306141
Bcl-2 overexpression enhances tumor-specific T-cell survivalQ36327125
Regulated expression of telomerase activity in human T lymphocyte development and activationQ36366852
Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells.Q36369031
Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors.Q36424249
Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasisQ36427380
Chromatin structural elements and chromosomal translocations in leukemiaQ36558869
Chromosome abnormalities in advanced stage lymphoblastic lymphoma of children and adolescents: a report from CCG-E08.Q36686740
Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activityQ36726945
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Safety Issues Related to Retroviral-Mediated Gene Transfer in HumansQ37219609
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)5168-5177
P577publication date2007-03-12
P1433published inBloodQ885070
P1476titleCytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene
P478volume109

Reverse relations

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