Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma.

scientific article published on 10 January 2012

Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2011-08-376236
P932PMC publication ID3311257
P698PubMed publication ID22234692
P5875ResearchGate publication ID221738039

P50authorRichard FlavellQ2149481
Till StrowigQ51326231
Ellice WongQ114736416
P2093author name stringLin Zhang
David G Schatz
Kavita M Dhodapkar
Madhav V Dhodapkar
Srinivas Koduru
Matthew P Strout
Ranjini Sundaram
P2860cites workClass switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.Q30490975
A coming-of-age story: activation-induced cytidine deaminase turns 10.Q33605445
Origin of chromosomal translocations in lymphoid cancerQ33870612
Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombinationQ34095055
Multiple myeloma: evolving genetic events and host interactionsQ34624999
Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cellsQ35102323
Controversies in clinical cancer dormancyQ35134139
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.Q35148879
Dendritic cells and malignant plasma cells: an alliance in multiple myeloma tumor progression?Q35584599
CD28-mediated regulation of multiple myeloma cell proliferation and survivalQ35828826
Enhancement of clonogenicity of human multiple myeloma by dendritic cellsQ36082990
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.Q36146840
Vigorous premalignancy-specific effector T cell response in the bone marrow of patients with monoclonal gammopathyQ36371527
In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas.Q36375533
MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myelomaQ36446189
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor developmentQ36853393
Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myelomaQ36915925
The malignant clone and the bone-marrow environmentQ37028547
Estrogen directly activates AID transcription and functionQ37061875
RANK/RANKL: regulators of immune responses and bone physiologyQ37348448
Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone diseaseQ37396070
Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytesQ37419452
gammaH2AX: a sensitive molecular marker of DNA damage and repairQ37687078
Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversityQ37704005
Impaired NHEJ function in multiple myelomaQ39913010
Bortezomib disrupts tumour-dendritic cell interactions in myeloma and lymphoma: therapeutic implicationsQ40183444
Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patientsQ42742001
A Cyclooxygenase-2/Prostaglandin E2 Pathway Augments Activation-Induced Cytosine Deaminase Expression within Replicating Human B CellsQ42870169
AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.Q43059808
High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL diseaseQ43127229
Expression of the AID protein in normal and neoplastic B cellsQ45013739
AID is required for c-myc/IgH chromosome translocations in vivoQ45021537
Localization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myelomaQ45037008
Two levels of protection for the B cell genome during somatic hypermutation.Q46755254
Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions.Q53294172
Detection of Kaposi's sarcoma herpesvirus DNA sequences in multiple myeloma bone marrow stromal cellsQ53936841
Immature dendritic cells from patients with multiple myeloma are prone to osteoclast differentiation in vitroQ54373221
Osteoprotegerin expression in dendritic cells increases with maturation and is NF-kappaB-dependentQ79435466
A role for activation-induced cytidine deaminase in the host response against a transforming retrovirusQ79746229
The relative spatial distribution of CFU-S in the mouse spleenQ93631820
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P304page(s)2302-2309
P577publication date2012-01-10
P1433published inBloodQ885070
P1476titleDendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma
P478volume119

Reverse relations

cites work (P2860)
Q64231693A 30-Year-Old Carrier of Gaucher Disease with Multiple Myeloma
Q41091865A gene expression inflammatory signature specifically predicts multiple myeloma evolution and patients survival.
Q37068312Cancer as an immune-mediated disease
Q36719221Clonal Immunoglobulin against Lysolipids in the Origin of Myeloma
Q64061199Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells
Q36097337Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways
Q38932298Extracellular matrix and the myeloid-in-myeloma compartment: balancing tolerogenic and immunogenic inflammation in the myeloma niche
Q38115576Genomic instability in multiple myeloma: mechanisms and therapeutic implications
Q64257450Germline Risk Contribution to Genomic Instability in Multiple Myeloma
Q26796307Immune Modulation in Hematologic Malignancies
Q41971408Lysosomal Storage Disorders and Malignancy
Q38979865MGUS to myeloma: a mysterious gammopathy of underexplored significance
Q38188051Mechanisms of oncogenic chromosomal translocations
Q47702288MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells
Q37402009Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice.
Q35175289NOD/SCID-GAMMA mice are an ideal strain to assess the efficacy of therapeutic agents used in the treatment of myeloma bone disease
Q38702294Overexpression of B-cell lymphoma 6 alters gene expression profile in a myeloma cell line and is associated with decreased DNA damage response
Q40843669PREVENTING THE CHROMOSOMAL TRANSLOCATIONS THAT CAUSE CANCER
Q91844697Transcription factor binding at Ig enhancers is linked to somatic hypermutation targeting
Q91644110Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies

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