Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans

scientific article published in June 2007

Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1128/MMBR.00009-06
P932PMC publication ID1899878
P698PubMed publication ID17554048
P5875ResearchGate publication ID6282866

P2093author name stringPatrick Van Dijck
Asis Datta
Subhrajit Biswas
P2860cites workPMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance.Q53873705
Oroesophageal candidiasis is lethal for transgenic mice with combined natural killer and T-cell defects.Q54002501
Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans.Q54558800
Adhesive and Mammalian Transglutaminase Substrate Properties of Candida albicans Hwp1Q56019296
Systemic Infection Following Intravenous Inoculation of Mice with Candida albicans int1 Mutant StrainsQ61199281
The role and relevance of phospholipase D1 during growth and dimorphism of Candida albicansQ61441059
Phospholipid composition and subcellular distribution in yeast and mycelial forms of Candida albicansQ67970760
A mutant of Candida albicans deficient in beta-N-acetylglucosaminidase (chitobiase)Q68231357
Analysis of the nag regulon from Escherichia coli K12 and Klebsiella pneumoniae and of its regulationQ69566669
A characterization of pH-regulated dimorphism in Candida albicansQ70357520
The detection and analysis of chitinase activity from the yeast form of Candida albicansQ70375396
Cdc25 is not the signal receiver for glucose induced cAMP response in S. cerevisiaeQ72370691
Detection of extracellular phospholipase activity in Candida albicans and Rhodotorula rubraQ73146181
The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicansQ73167647
Filamentous growth of Candida albicans in response to physical environmental cues and its regulation by the unique CZF1 geneQ73189498
The MET3 promoter: a new tool for Candida albicans molecular geneticsQ73189519
Functional analysis of CaRAP1 , encoding the Repressor/activator protein 1 of Candida albicansQ73298887
GPR1 regulates filamentous growth through FLO11 in yeast Saccharomyces cerevisiaeQ73330008
Adaptation of the Efg1p morphogenetic pathway in Candida albicans by negative autoregulation and PKA-dependent repression of the EFG1 geneQ73507134
Regulation of N-acetylglucosaminidase production in Candida albicansQ73912001
Suppression of sorbitol dependence in a strain bearing a mutation in the SRB1/PSA1/VIG9 gene encoding GDP-mannose pyrophosphorylase by PDE2 overexpression suggests a role for the Ras/cAMP signal-transduction pathway in the control of yeast cell-wallQ74270882
A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicansQ74285641
Role of pH response in Candida albicans virulenceQ74322287
Reintroduction of the PLB1 gene into Candida albicans restores virulence in vivoQ74459785
Extracellular phospholipases as universal virulence factor in pathogenic fungiQ74526178
Signaling via cAMP in fungi: interconnections with mitogen-activated protein kinase pathwaysQ77501139
Essential role of the Candida albicans transglutaminase substrate, hyphal wall protein 1, in lethal oroesophageal candidiasis in immunodeficient miceQ77691325
Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicansQ77748392
Differential expression of Candida albicans phospholipase B (PLB1) under various environmental and physiological conditionsQ78953331
Ssn6, an important factor of morphological conversion and virulence in Candida albicansQ78967868
The cAMP phosphodiesterase encoded by CaPDE2 is required for hyphal development in Candida albicansQ79107877
Use of green fluorescent protein fusions to analyse the N- and C-terminal signal peptides of GPI-anchored cell wall proteins in Candida albicansQ79338666
Large-scale gene function analysis in Candida albicansQ79839447
Transcriptional response of Candida albicans to hypoxia: linkage of oxygen sensing and Efg1p-regulatory networksQ79947349
RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal developmentQ79953018
Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factorQ80934272
A bivalent dissectional analysis of the high-affinity interactions between Cdc42 and the Cdc42/Rac interactive binding domains of signaling kinases in Candida albicansQ81604551
Flanking direct repeats of hisG alter URA3 marker expression at the HWP1 locus of Candida albicansQ81627664
The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicansQ81631164
Candida albicans PLD I activity is required for full virulenceQ95822140
A single-transformation gene function test in diploid Candida albicansQ39500840
Efg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding proteinQ39504052
Avirulence of Candida albicans CaHK1 mutants in a murine model of hematogenously disseminated candidiasisQ39511574
Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulatorQ39512460
Reduced virulence of HWP1-deficient mutants of Candida albicans and their interactions with host cellsQ39515062
Candida albicans INT1-induced filamentation in Saccharomyces cerevisiae depends on Sla2pQ39526850
The basic helix-loop-helix transcription factor Cph2 regulates hyphal development in Candida albicans partly via TEC1Q39528081
Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicansQ39547928
A G1 cyclin is necessary for maintenance of filamentous growth in Candida albicansQ39551388
The molecular genetics of Candida albicansQ39586019
Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicansQ39601237
The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicansQ39601713
Specificity determinants of proteolytic processing of Aspergillus PacC transcription factor are remote from the processing site, and processing occurs in yeast if pH signalling is bypassedQ39610969
Cleavage of immunoglobulins by pathogenic yeasts of the genus Candida.Q39612271
Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organsQ39655406
Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicansQ39659009
Gpa2, a G-protein alpha subunit required for hyphal development in Candida albicansQ39692213
The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans.Q39751926
Characterization of the pH signal transduction pathway gene palA of Aspergillus nidulans and identification of possible homologsQ39844874
The Sho1 adaptor protein links oxidative stress to morphogenesis and cell wall biosynthesis in the fungal pathogen Candida albicans.Q39890876
Alpha-pheromone-induced "shmooing" and gene regulation require white-opaque switching during Candida albicans matingQ39981794
Gratuitous induction by N-acetylmannosamine of germ tube formation and enzymes for N-acetylglucosamine utilization in Candida albicansQ39984759
Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrityQ40016068
Candida albicans lacking the gene encoding the regulatory subunit of protein kinase A displays a defect in hyphal formation and an altered localization of the catalytic subunit.Q40510462
Candida albicans Csy1p is a nutrient sensor important for activation of amino acid uptake and hyphal morphogenesisQ40510519
The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH.Q40805816
Genetic analysis of Cln/Cdc28 regulation of cell morphogenesis in budding yeastQ40874618
The G1 cyclin Cln3 regulates morphogenesis in Candida albicansQ40895537
CaNAT1, a heterologous dominant selectable marker for transformation of Candida albicans and other pathogenic Candida speciesQ40998517
Regulation of n-acetylglucosamine uptake in yeastQ41196586
Gene regulation during high-frequency switching in Candida albicansQ41356315
Global role of the protein kinase Gcn2 in the human pathogen Candida albicans.Q41823869
In Candida albicans, the Nim1 kinases Gin4 and Hsl1 negatively regulate pseudohypha formation and Gin4 also controls septin organizationQ41825457
The Cek1 and Hog1 mitogen-activated protein kinases play complementary roles in cell wall biogenesis and chlamydospore formation in the fungal pathogen Candida albicans.Q41869795
Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis.Q41874538
Tetracycline-inducible gene expression and gene deletion in Candida albicansQ41883686
Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicansQ42074010
Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungiQ42135090
Increased high-affinity phosphodiesterase PDE2 gene expression in germ tubes counteracts CAP1-dependent synthesis of cyclic AMP, limits hypha production and promotes virulence of Candida albicansQ42452804
Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicansQ42513356
Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid controlQ42590211
Identification of a putative transcription factor in Candida albicans that can complement the mating defect of Saccharomyces cerevisiae ste12 mutants.Q42600864
GAP1, the general amino acid permease gene of Saccharomyces cerevisiae. Nucleotide sequence, protein similarity with the other bakers yeast amino acid permeases, and nitrogen catabolite repressionQ42633249
Cloning and sequencing of the genes for N-acetylglucosamine use that construct divergent operons (nagE-nagAC) from Vibrio cholerae non-O1.Q42663983
Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1.Q42665164
Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicansQ42683173
Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicansQ43408470
Expression of transglutaminase substrate activity on Candida albicans germ tubes through a coiled, disulfide-bonded N-terminal domain of Hwp1 requires C-terminal glycosylphosphatidylinositol modificationQ43497796
A human-curated annotation of the Candida albicans genomeQ21145286
The diploid genome sequence of Candida albicansQ21999078
Regulation of gene expression by ambient pH in filamentous fungi and yeastsQ24533246
EFG1 null mutants of Candida albicans switch but cannot express the complete phenotype of white-phase budding cellsQ24548979
Exploring the metabolic and genetic control of gene expression on a genomic scaleQ27860705
Genomic expression programs in the response of yeast cells to environmental changesQ27860823
Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiaeQ27929742
The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunitsQ27929918
Two yeast forkhead genes regulate the cell cycle and pseudohyphal growthQ27931177
Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiaeQ27932174
The transcription factor Rim101p governs ion tolerance and cell differentiation by direct repression of the regulatory genes NRG1 and SMP1 in Saccharomyces cerevisiae.Q27932302
The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes.Q27932310
Mss11p is a central element of the regulatory network that controls FLO11 expression and invasive growth in Saccharomyces cerevisiae.Q27932677
Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiaeQ27932763
Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiaeQ27932764
Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homologQ27932910
The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiaeQ27932984
Regulation of transcription factor latency by receptor-activated proteolysisQ27933250
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiaeQ27933331
Ssn6-Tup1 is a general repressor of transcription in yeastQ27933537
A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and matingQ27933651
Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stressQ27933664
Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast.Q27933733
The PDE1-encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signalingQ27933961
The protease activity of a calpain-like cysteine protease in Saccharomyces cerevisiae is required for alkaline adaptation and sporulation.Q27934081
Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae.Q27934197
A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2.Q27934307
Relationship of DFG16 to the Rim101p pH response pathway in Saccharomyces cerevisiae and Candida albicansQ27935014
Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phaseQ27935191
Molecular characterization of the yeast meiotic regulatory gene RIM1.Q27935275
Yeast PalA/AIP1/Alix homolog Rim20p associates with a PEST-like region and is required for its proteolytic cleavageQ27935670
The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.Q27935804
Target hub proteins serve as master regulators of development in yeastQ27936046
The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiaeQ27936490
Saccharomyces cerevisiae TEC1 is required for pseudohyphal growthQ27936711
Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RASQ27936756
SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcriptionQ27936836
Alkaline response genes of Saccharomyces cerevisiae and their relationship to the RIM101 pathwayQ27937044
The GPI-anchored protein CaEcm33p is required for cell wall integrity, morphogenesis and virulence in Candida albicansQ27937120
Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal developmentQ27937284
Determinants for glycophospholipid anchoring of the Saccharomyces cerevisiae GAS1 protein to the plasma membraneQ27937642
Combinatorial control required for the specificity of yeast MAPK signalingQ27937910
A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeastQ27938083
A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucoseQ27938758
The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.Q27938774
GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathwayQ27938812
Proteolytic activation of Rim1p, a positive regulator of yeast sporulation and invasive growthQ27939291
Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiaeQ28143822
Sex and sugar in yeast: two distinct GPCR systems.Q28344568
A potential phosphorylation site for an A-type kinase in the Efg1 regulator protein contributes to hyphal morphogenesis of Candida albicansQ28362095
Genetic analysis of regulatory mutants affecting synthesis of extracellular proteinases in the yeast Yarrowia lipolytica: identification of a RIM101/pacC homologQ28776779
Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeastQ29614487
Osmotic stress signaling and osmoadaptation in yeastsQ29617597
Nonfilamentous C. albicans mutants are avirulentQ29617839
Cdc24, the GDP-GTP exchange factor for Cdc42, is required for invasive hyphal growth of Candida albicansQ30164900
A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicansQ30476319
The ALS6 and ALS7 genes of Candida albicansQ30881745
Expression of the Candida albicans gene ALS1 in Saccharomyces cerevisiae induces adherence to endothelial and epithelial cellsQ32074898
N-acetylglucosamine-inducible CaGAP1 encodes a general amino acid permease which co-ordinates external nitrogen source response and morphogenesis in Candida albicansQ33188344
Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrestQ33191666
Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1pQ33217380
Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo.Q33250085
Candida albicans Als3p is required for wild-type biofilm formation on silicone elastomer surfacesQ33250648
Non-lethal Candida albicans cph1/cph1 efg1/efg1 transcription factor mutant establishing restricted zone of infection in a mouse model of systemic infection.Q53594979
Targeted gene deletion in Candida albicans wild-type strains by MPAR flipping.Q53857157
PRR1, a homolog of Aspergillus nidulans palF, controls pH-dependent gene expression and filamentation in Candida albicansQ33993296
Effect of environmental pH on morphological development of Candida albicans is mediated via the PacC-related transcription factor encoded by PRR2.Q33993303
CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans.Q33996222
The histone deacetylase genes HDA1 and RPD3 play distinct roles in regulation of high-frequency phenotypic switching in Candida albicansQ33996677
Misexpression of the opaque-phase-specific gene PEP1 (SAP1) in the white phase of Candida albicans confers increased virulence in a mouse model of cutaneous infectionQ34002858
Repression of hyphal proteinase expression by the mitogen-activated protein (MAP) kinase phosphatase Cpp1p of Candida albicans is independent of the MAP kinase Cek1p.Q34005397
Attenuation of virulence and changes in morphology in Candida albicans by disruption of the N-acetylglucosamine catabolic pathwayQ34009918
Signal transduction cascades regulating fungal development and virulence.Q34010291
Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulenceQ34049806
NRG1, a repressor of filamentous growth in C.albicans, is down-regulated during filament inductionQ34077791
NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicansQ34081697
Control of pseudohyphae formation in Saccharomyces cerevisiaeQ34127832
The Aspergillus fumigatus StuA protein governs the up-regulation of a discrete transcriptional program during the acquisition of developmental competenceQ34148271
Candida Albicans: a molecular revolution built on lessons from budding yeastQ34161985
EFG1 is a major regulator of cell wall dynamics in Candida albicans as revealed by DNA microarrays.Q34166072
Deletions of endocytic components VPS28 and VPS32 affect growth at alkaline pH and virulence through both RIM101-dependent and RIM101-independent pathways in Candida albicans.Q34194520
The ALS gene family of Candida albicansQ34207790
The receptors for mammalian sweet and umami tasteQ34278862
Virulence factors of Candida albicansQ34297805
The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicansQ34298383
G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformansQ34325690
The distinct morphogenic states of Candida albicansQ34329798
Cdc42p GTPase regulates the budded-to-hyphal-form transition and expression of hypha-specific transcripts in Candida albicansQ34360551
High-frequency switching in Candida albicansQ34402581
Control of Bro1-domain protein Rim20 localization by external pH, ESCRT machinery, and the Saccharomyces cerevisiae Rim101 pathwayQ34407330
Mating in Candida albicans and the search for a sexual cycleQ34420674
Phospholipases of Candida albicansQ34477260
Exploring the protein interactome using comprehensive two-hybrid projectsQ34487025
Candida commensalism and virulence: the evolution of phenotypic plasticityQ34500611
Expression of the Candida albicans morphogenesis regulator gene CZF1 and its regulation by Efg1p and Czf1pQ34601661
TUP1, CPH1 and EFG1 make independent contributions to filamentation in candida albicansQ34609405
Identification and characterization of TUP1-regulated genes in Candida albicansQ34610317
The DNA binding protein Rfg1 is a repressor of filamentation in Candida albicansQ34612309
Candida albicans RIM101 pH response pathway is required for host-pathogen interactionsQ33592905
Cloning and expression of a gene encoding an integrin-like protein in Candida albicansQ33622704
Ras signaling is required for serum-induced hyphal differentiation in Candida albicans.Q33637947
The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae.Q33653472
Regulatory networks controlling Candida albicans morphogenesisQ33702252
Adhesins in Candida albicansQ33718388
Cyclin Cln3p links G1 progression to hyphal and pseudohyphal development in Candida albicansQ33719138
Cloning and characterization of PRA1, a gene encoding a novel pH-regulated antigen of Candida albicansQ33722713
The G protein-coupled receptor Gpr1 and the Galpha protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans.Q33734589
Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasisQ33754752
The pH of the host niche controls gene expression in and virulence of Candida albicans.Q33756584
Regulation of the Cdc42/Cdc24 GTPase module during Candida albicans hyphal growthQ33770569
Role for the SCFCDC4 ubiquitin ligase in Candida albicans morphogenesisQ33841398
Induction of the Candida albicans filamentous growth program by relief of transcriptional repression: a genome-wide analysisQ33841447
Efg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicansQ33858493
Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicansQ33859372
The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida albicansQ33877116
Invasive lesions containing filamentous forms produced by a Candida albicans mutant that is defective in filamentous growth in cultureQ33877327
Hyphal guidance and invasive growth in Candida albicans require the Ras-like GTPase Rsr1p and its GTPase-activating protein Bud2pQ33884544
CDC42 is required for polarized growth in human pathogen Candida albicans.Q33905537
Arrestin-related proteins mediate pH signaling in fungi.Q33922905
A contact-activated kinase signals Candida albicans invasive growth and biofilm developmentQ33936541
Cell wall integrity signaling in Saccharomyces cerevisiaeQ33939988
Candida albicans Int1p interacts with the septin ring in yeast and hyphal cellsQ33948538
Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicansQ33948564
Turning genes off by Ssn6-Tup1: a conserved system of transcriptional repression in eukaryotesQ33953233
RIM101-dependent and-independent pathways govern pH responses in Candida albicansQ33961756
Dominant active alleles of RIM101 (PRR2) bypass the pH restriction on filamentation of Candida albicans.Q33964252
Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicansQ33967829
Asm-1+, a Neurospora crassa gene related to transcriptional regulators of fungal developmentQ33968861
Invasive filamentous growth of Candida albicans is promoted by Czf1p-dependent relief of Efg1p-mediated repression.Q34614782
Niche-specific regulation of central metabolic pathways in a fungal pathogen.Q34651681
Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicansQ34976954
The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epitheliumQ35012319
URA3 as a selectable marker for disruption and virulence assessment of Candida albicans genesQ35070860
A glucose sensor in Candida albicansQ35075215
Depletion of a polo-like kinase in Candida albicans activates cyclase-dependent hyphal-like growthQ35153719
Candida albicans secreted aspartyl proteinases in virulence and pathogenesisQ35215948
Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicansQ35289673
Reduced virulence of Candida albicans PHR1 mutantsQ35452128
Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence.Q35554184
Ammonia assimilation by Saccharomyces cerevisiaeQ35557804
Role of aspartic proteases in disseminated Candida albicans infection in miceQ35567040
Reduced virulence of Candida albicans MKC1 mutants: a role for mitogen-activated protein kinase in pathogenesisQ35567860
Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels are determined by environmental factors.Q35594348
The sea pansy Renilla reniformis luciferase serves as a sensitive bioluminescent reporter for differential gene expression in Candida albicansQ35600439
Diverged binding specificity of Rim101p, the Candida albicans ortholog of PacC.Q35612423
A monitor for bud emergence in the yeast morphogenesis checkpointQ35670382
Unique and Redundant Roles for HOG MAPK Pathway Components as Revealed by Whole-Genome Expression AnalysisQ35796834
The inducible N-acetylglucosamine catabolic pathway gene cluster in Candida albicans: discrete N-acetylglucosamine-inducible factors interact at the promoter of NAG1Q35838663
The eukaryotic plasma membrane as a nutrient-sensing device.Q35902812
APSES proteins regulate morphogenesis and metabolism in Candida albicansQ35918681
A protein's final ESCRT.Q35966140
Regulation of the osmoregulatory HOG MAPK cascade in yeastQ35983907
Evaluation of the Roles of Four Candida albicans Genes in Virulence by Using Gene Disruption Strains That Express URA3 from the Native LocusQ36045325
Cyclic AMP Signaling Pathway Modulates Susceptibility of Candida Species and Saccharomyces cerevisiae to Antifungal Azoles and Other Sterol Biosynthesis InhibitorsQ36048538
"White-opaque transition": a second high-frequency switching system in Candida albicansQ36226607
Alternative Candida albicans lifestyles: growth on surfacesQ36253562
Fungal pathogens research: novel and improved molecular approaches for the discovery of antifungal drug targetsQ36352168
Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infectionQ36370514
The MAP kinase signal transduction network in Candida albicans.Q36426498
Biofilms and their role in the resistance of pathogenic Candida to antifungal agentsQ36447053
Candida resistance and its clinical relevanceQ36484954
COS1, a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen Candida albicansQ36507594
The Candida Genome Database: facilitating research on Candida albicans molecular biologyQ36552059
Morphogenesis and cell cycle progression in Candida albicansQ36554042
Activation mechanism of the multifunctional transcription factor repressor-activator protein 1 (Rap1p)Q36560430
PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesisQ36566357
PHR2 of Candida albicans encodes a functional homolog of the pH-regulated gene PHR1 with an inverted pattern of pH-dependent expressionQ36573122
Residues in the WD repeats of Tup1 required for interaction with alpha2.Q36573183
Aspergillus asexual reproduction and sexual reproduction are differentially affected by transcriptional and translational mechanisms regulating stunted gene expressionQ36573316
Genetic regulation of nitrogen metabolism in the fungi.Q36574195
Macrophages in resistance to candidiasisQ36574240
Use of DNA microarray technology and gene expression profiles to investigate the pathogenesis, cell biology, antifungal susceptibility and diagnosis of Candida albicansQ36624102
CO2 sensing in fungi and beyondQ36625428
Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicansQ36690032
Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal developmentQ36690106
Molecular cloning and expression of the Candida albicans beta-N-acetylglucosaminidase (HEX1) geneQ36748593
Putative virulence factors of Candida albicansQ36784576
The Candida albicans HYR1 gene, which is activated in response to hyphal development, belongs to a gene family encoding yeast cell wall proteinsQ36819924
The Candida albicans PKC1 gene encodes a protein kinase C homolog necessary for cellular integrity but not dimorphismQ36820567
Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulenceQ36822797
Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae.Q37064119
Tyrosol is a quorum-sensing molecule in Candida albicansQ37416044
Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating typeQ37502523
Recruitment of the Swi/Snf complex by Ste12-Tec1 promotes Flo8-Mss11-mediated activation of STA1 expressionQ37574914
Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesisQ37617187
Multivesicular body-ESCRT components function in pH response regulation in Saccharomyces cerevisiae and Candida albicansQ37657320
Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway.Q38289986
DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicansQ38295895
The Aspergillus nidulans abaA gene encodes a transcriptional activator that acts as a genetic switch to control developmentQ38309568
Snf7p, a component of the ESCRT-III protein complex, is an upstream member of the RIM101 pathway in Candida albicansQ38333304
Hyphal tip-associated localization of Cdc42 is F-actin dependent in Candida albicansQ38359857
TOS9 regulates white-opaque switching in Candida albicansQ38500130
Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol.Q39491534
Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicansQ39495714
HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1.Q39497122
Effect of nucleosides and nucleotides and the relationship between cellular adenosine 3':5'-cyclic monophosphate (cyclic AMP) and germ tube formation in Candida albicansQ43537149
Identification and characterization of the genes for N-acetylglucosamine kinase and N-acetylglucosamine-phosphate deacetylase in the pathogenic fungus Candida albicansQ43572425
The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acidsQ43778555
Signaling of ambient pH in Aspergillus involves a cysteine proteaseQ43944392
Host versus in vitro signals and intrastrain allelic differences in the expression of a Candida albicans virulence geneQ44004756
Characterization of the CaNAG3, CaNAG4, and CaNAG6 genes of the pathogenic fungus Candida albicans: possible involvement of these genes in the susceptibilities of cytotoxic agentsQ44036745
The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicansQ44120428
The two isoforms of the cAMP-dependent protein kinase catalytic subunit are involved in the control of dimorphism in the human fungal pathogen Candida albicans.Q44294167
Two membrane proteins located in the Nag regulon of Candida albicans confer multidrug resistanceQ44317777
Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efg1 mutant is associated with attenuated virulence during infection of oral epitheliumQ44516317
Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeastQ44532187
Reduced pathogenicity of a Candida albicans MAP kinase phosphatase (CPP1) mutant in the murine mastitis modelQ44545967
An ER packaging chaperone determines the amino acid uptake capacity and virulence of Candida albicansQ44572537
The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiaeQ44655571
The role of nutrient regulation and the Gpa2 protein in the mating pheromone response of C. albicansQ44875850
Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascadeQ44888389
Identification of the dialysable serum inducer of germ-tube formation in Candida albicansQ45044353
Studies on the regulation of the two-component histidine kinase gene CHK1 in Candida albicans using the heterologous lacZ reporter geneQ45094856
When the stress of your environment makes you go HOG wildQ45165247
Carbon source induced yeast-to-hypha transition in Candida albicans is dependent on the presence of amino acids and on the G-protein-coupled receptor Gpr1.Q45236076
Phosphatidylinositol 3-kinase VPS34 of Candida albicans is involved in filamentous growth, secretion of aspartic proteases, and intracellular detoxificationQ45251246
Control of filament formation in Candida albicans by the transcriptional repressor TUP1.Q46154938
Deletion of PDE2, the gene encoding the high-affinity cAMP phosphodiesterase, results in changes of the cell wall and membrane in Candida albicansQ46403089
Squalene epoxidase encoded by ERG1 affects morphogenesis and drug susceptibilities of Candida albicansQ46450178
The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans.Q46633733
Homology, disruption and phenotypic analysis of CaGS Candida albicans gene induced during macrophage infectionQ46638394
Cell cycle arrest during S or M phase generates polarized growth via distinct signals in Candida albicansQ46642597
Cell integrity signaling activation in response to hyperosmotic shock in yeastQ46769022
Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulenceQ47238257
Candida glabrata Ste20 is involved in maintaining cell wall integrity and adaptation to hypertonic stress, and is required for wild-type levels of virulence.Q47426451
Allelic variation in the contiguous loci encoding Candida albicans ALS5, ALS1 and ALS9Q47590306
The ALS5 gene of Candida albicans and analysis of the Als5p N-terminal domainQ47805725
Rad6p represses yeast-hypha morphogenesis in the human fungal pathogen Candida albicansQ47878543
Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicansQ47946163
Putative membrane components of signal transduction pathways for ambient pH regulation in Aspergillus and meiosis in saccharomyces are homologousQ48012621
Isolation of CaSLN1 and CaNIK1, the genes for osmosensing histidine kinase homologues, from the pathogenic fungus Candida albicansQ48039813
Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4pQ48046730
A novel MAP-kinase kinase from Candida albicansQ48050816
Characterization of a Penicillium chrysogenum gene encoding a PacC transcription factor and its binding sites in the divergent pcbAB-pcbC promoter of the penicillin biosynthetic clusterQ48064405
Suppression of hyphal formation in Candida albicans by mutation of a STE12 homologQ48077116
A Candida albicans cyclic nucleotide phosphodiesterase: cloning and expression in Saccharomyces cerevisiae and biochemical characterization of the recombinant enzymeQ48081096
StuA is required for cell pattern formation in AspergillusQ48158659
The SAT1 flipper, an optimized tool for gene disruption in Candida albicansQ48168925
Candida albicans protein kinase CaHsl1p regulates cell elongation and virulence.Q50780306
A screen in Saccharomyces cerevisiae identified CaMCM1, an essential gene in Candida albicans crucial for morphogenesis.Q52109258
Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth.Q52110035
cAMP levels and in situ measurement of cAMP related enzymes during yeast-to-hyphae transition in Candida albicans.Q52243412
Biochemical and genetic characterization of Rbf1p, a putative transcription factor of Candida albicans.Q52524101
Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1.Q52529254
Isolation and characterization from pathogenic fungi of genes encoding ammonium permeases and their roles in dimorphism.Q52552131
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectCandida albicansQ310443
filamentous growth of a population of unicellular organisms in response to heatQ22269540
filamentous growth of a population of unicellular organisms in response to starvationQ22269551
filamentous growth of a population of unicellular organisms in response to chemical stimulusQ22269553
P304page(s)348-376
P577publication date2007-06-01
P1433published inMicrobiology and Molecular Biology ReviewsQ6839270
P1476titleEnvironmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans
P478volume71

Reverse relations

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Q40869543Transcription factor Efg1 shows a haploinsufficiency phenotype in modulating the cell wall architecture and immunogenicity of Candida albicans.
Q92936499Transcriptional control of hyphal morphogenesis in Candida albicans
Q35586885Two novel transcriptional regulators are essential for infection-related morphogenesis and pathogenicity of the rice blast fungus Magnaporthe oryzae
Q64102977Variation in Filamentous Growth and Response to Quorum-Sensing Compounds in Environmental Isolates of
Q44244693Variation in adhesion and germ tube formation of oral Candida using Egyptian propolis
Q33559838Virulence attenuation of Candida albicans genetic variants isolated from a patient with a recurrent bloodstream infection
Q33579140Yeasts in the gut: from commensals to infectious agents
Q38955918Zap1 control of cell-cell signaling in Candida albicans biofilms
Q42502266cAMP-independent signal pathways stimulate hyphal morphogenesis in Candida albicans
Q64112573from a Marine-Derived sp. Inhibit Hyphal Growth Induction in
Q36208847pH Regulates White-Opaque Switching and Sexual Mating in Candida albicans
Q33386007the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin

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