The Ras/cAMP/PKA signaling pathway and virulence in Candida albicans

scientific article published on December 2009

The Ras/cAMP/PKA signaling pathway and virulence in Candida albicans is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2217/FMB.09.106
P698PubMed publication ID19995187

P50authorDeborah A HoganQ37829375
P2093author name stringPaula Sundstrom
P2860cites workTranscriptional response of Candida albicans upon internalization by macrophagesQ24563309
Role of actin cytoskeletal dynamics in activation of the cyclic AMP pathway and HWP1 gene expression in Candida albicansQ24672853
Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiationQ27937159
Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated proteinQ27940176
Nonfilamentous C. albicans mutants are avirulentQ29617839
Developmental regulation of an adhesin gene during cellular morphogenesis in the fungal pathogen Candida albicans.Q30479432
Farnesol-induced apoptosis in Candida albicansQ30487814
Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cellsQ33274746
the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritinQ33386007
The G protein-coupled receptor Gpr1 and the Galpha protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans.Q33734589
Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathwayQ33771219
Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicansQ33948564
Hyphal elongation is regulated independently of cell cycle in Candida albicansQ33953337
CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans.Q33996222
Oral candidosis.Q34116655
Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infectionQ34117682
Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transitionQ34167828
The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicansQ34298383
Expression of the Candida albicans morphogenesis regulator gene CZF1 and its regulation by Efg1p and Czf1pQ34601661
Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicansQ35289673
Morphogenesis in Candida albicansQ35674379
A 368-base-pair cis-acting HWP1 promoter region, HCR, of Candida albicans confers hypha-specific gene regulation and binds architectural transcription factors Nhp6 and Gcf1pQ35783689
Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicansQ35856686
APSES proteins regulate morphogenesis and metabolism in Candida albicansQ35918681
Cyclic AMP Signaling Pathway Modulates Susceptibility of Candida Species and Saccharomyces cerevisiae to Antifungal Azoles and Other Sterol Biosynthesis InhibitorsQ36048538
Unique phenotype of opaque cells in the white-opaque transition of Candida albicansQ36274155
Genome-wide transcriptional profiling of the cyclic AMP-dependent signaling pathway during morphogenic transitions of Candida albicansQ36313748
Talking to themselves: autoregulation and quorum sensing in fungiQ36445103
Candida-host interactions in HIV disease: relationships in oropharyngeal candidiasisQ36467675
Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulenceQ36822797
Infection-related gene expression in Candida albicansQ36914013
Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicansQ36914245
Niche-specific gene expression during C. albicans infectionQ36914830
Antimicrobials as a contributory factor in oral candidosis--a brief overview.Q37095588
Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesisQ37195641
Molecular networks in the fungal pathogen Candida albicansQ37402027
Sensing the environment: response of Candida albicans to the X factorQ37497525
Development and characterization of an in vivo central venous catheter Candida albicans biofilm model.Q37523933
Transcription profiling of cyclic AMP signaling in Candida albicans.Q37537951
Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesisQ37617187
Function of Candida albicans adhesin Hwp1 in biofilm formation.Q38499591
Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol.Q39491534
Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicansQ39601237
Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organsQ39655406
Candida albicans lacking the gene encoding the regulatory subunit of protein kinase A displays a defect in hyphal formation and an altered localization of the catalytic subunit.Q40510462
ALS3 and ALS8 represent a single locus that encodes a Candida albicans adhesin; functional comparisons between Als3p and Als1pQ40534766
Complementary adhesin function in C. albicans biofilm formationQ41725448
Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signalingQ41995021
Temporal and spatial control of HGC1 expression results in Hgc1 localization to the apical cells of hyphae in Candida albicansQ42125525
MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicansQ42148559
Phosphorylation of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida albicans hyphal growthQ42411923
Increased high-affinity phosphodiesterase PDE2 gene expression in germ tubes counteracts CAP1-dependent synthesis of cyclic AMP, limits hypha production and promotes virulence of Candida albicansQ42452804
Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1.Q42665164
Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genesQ43071633
SRV2, a gene required for RAS activation of adenylate cyclase in yeastQ43651965
Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicansQ43808791
Interactions between regulatory and catalytic subunits of the Candida albicans cAMP-dependent protein kinase are modulated by autophosphorylation of the regulatory subunit.Q45712637
Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005-2006).Q46072663
Deletion of PDE2, the gene encoding the high-affinity cAMP phosphodiesterase, results in changes of the cell wall and membrane in Candida albicansQ46403089
Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1pQ46487837
Catalytic isoforms Tpk1 and Tpk2 of Candida albicans PKA have non-redundant roles in stress response and glycogen storage.Q47949543
Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development.Q50920927
Stimulation of cell motility and expression of late markers of differentiation in human oral keratinocytes by Candida albicans.Q51757188
Role of the fungal Ras-protein kinase A pathway in governing epithelial cell interactions during oropharyngeal candidiasis.Q53625295
Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans.Q54558800
Adhesive and Mammalian Transglutaminase Substrate Properties of Candida albicans Hwp1Q56019296
P433issue10
P921main subjectCandida albicansQ310443
P1104number of pages8
P304page(s)1263-1270
P577publication date2009-12-01
P1433published inFuture MicrobiologyQ15759961
P1476titleThe Ras/cAMP/PKA signaling pathway and virulence in Candida albicans
P478volume4

Reverse relations

cites work (P2860)
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