Mannich base limits Candida albicans virulence by inactivating Ras-cAMP-PKA pathway

scientific article published in Scientific Reports

Mannich base limits Candida albicans virulence by inactivating Ras-cAMP-PKA pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-018-32935-9
P932PMC publication ID6175908
P698PubMed publication ID30297833

P50authorVinothkannan RavichandiranQ85609349
P2093author name stringArvind Kumar Ray
Satish Kumar Rajasekharan
Chakkaravarthi Kamalanathan
Ann Susan Satish
Sucharitha Kannappan Mohanvel
P2860cites workMannich bases: an important pharmacophore in present scenarioQ27016024
Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathwaysQ28477230
Gymnemic acids inhibit hyphal growth and virulence in Candida albicansQ28533240
Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence PathwaysQ28547568
Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicansQ33948564
Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans.Q54558800
The transcriptional regulator Nrg1p controls Candida albicans biofilm formation and dispersionQ34177651
Transcriptional control of dimorphism in Candida albicansQ34455374
Candida albicans hyphal initiation and elongationQ34633128
Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transportersQ35120105
Synergy of flavonoids with HDAC inhibitor: new approach to target Candida tropicalis biofilmsQ35142574
Quercetin sensitizes fluconazole-resistant candida albicans to induce apoptotic cell death by modulating quorum sensingQ35168915
The RAS-adenylate cyclase pathway and cell cycle control in Saccharomyces cerevisiaeQ35534769
Effects of magnolol and honokiol on adhesion, yeast-hyphal transition, and formation of biofilm by Candida albicansQ35566882
Inhibitory Effect of Sophorolipid on Candida albicans Biofilm Formation and Hyphal Growth.Q35974693
Inhibition of Candida albicans Biofilm Formation by the Synthetic Lactoferricin Derived Peptide hLF1-11.Q36208305
Candida albicans pathogenicity mechanisms.Q36845868
Ras signaling gets fine-tuned: regulation of multiple pathogenic traits of Candida albicansQ37263603
Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradationQ37571382
The Ras/cAMP/PKA signaling pathway and virulence in Candida albicansQ37648692
Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signalsQ37947775
Candida albicans morphogenesis and host defence: discriminating invasion from colonization.Q37967076
Mannich bases in medicinal chemistry and drug design.Q38280905
Efficacy of anidulafungin in 539 patients with invasive candidiasis: a patient-level pooled analysis of six clinical trials.Q38811035
Tumor necrosis factor prevents Candida albicans biofilm formation.Q40235960
Fungal infection: Protecting from Candida albicansQ40558979
Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungiQ42135090
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity.Q46190901
Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activitiesQ46448664
Evaluation of antimicrobial activities of several mannich bases and their derivativesQ46568990
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectCandida albicansQ310443
P304page(s)14972
P577publication date2018-10-08
P1433published inScientific ReportsQ2261792
P1476titleMannich base limits Candida albicans virulence by inactivating Ras-cAMP-PKA pathway
P478volume8

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