Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts

scientific article published in April 2012

Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1097/TP.0B013E3182472850
P932PMC publication ID3314133
P698PubMed publication ID22391577

P2093author name stringDavide Ricci
Henry D Tazelaar
Christopher G A McGregor
Guerard W Byrne
Paul G Stalboerger
Naoto Miyagi
Zeji Du
Elise A Oehler
P2860cites workTransgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damageQ72989924
Pig cells that lack the gene for alpha1-3 galactosyltransferase express low levels of the gal antigenQ73045839
Acute vascular rejectionQ77313011
Coagulation cascade activation triggers early failure of pig hearts expressing human complement regulatory genesQ79532880
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experienceQ81199195
Effective antiplatelet therapy does not prolong transgenic pig to baboon cardiac xenograft survivalQ28210539
Antigraft antibody-mediated expression of metalloproteinases on endothelial cells. Differential expression of TIMP-1 and ADAM-10 depends on antibody specificity and isotype.Q32069292
Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboonsQ33718060
Identification of new carbohydrate and membrane protein antigens in cardiac xenotransplantationQ33759347
Potential use of genetically modified pigs as organ donors for transplantation into humansQ33811447
Production of alpha 1,3-galactosyltransferase-deficient pigsQ33963251
The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipientsQ34055520
Incidence of hyperacute rejection in pig-to-primate transplantation using organs from hDAF-transgenic donorsQ34608583
Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboonsQ36691036
The vascular and coagulation issues in xenotransplantationQ37495795
Characterization of natural human anti-non-gal antibodies and their effect on activation of porcine gal-deficient endothelial cellsQ38299548
Changes in cardiac gene expression after pig-to-primate orthotopic xenotransplantationQ42691617
Comparison of Gal and non-Gal-mediated cardiac xenograft rejectionQ42746065
Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantationQ43239968
Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft functionQ46427137
Cardiac xenotransplantation: recent preclinical progress with 3-month median survivalQ46695733
Preformed antibodies to alpha1,3-galactosyltransferase gene-knockout (GT-KO) pig cells in humans, baboons, and monkeys: implications for xenotransplantationQ46812792
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectxenograftQ64148587
P304page(s)686-692
P577publication date2012-04-01
P1433published inTransplantationQ15730500
P1476titleHuman CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts
P478volume93

Reverse relations

cites work (P2860)
Q33752292Anti-non-Gal-specific combination treatment with an anti-idiotypic Ab and an inhibitory small molecule mitigates the xenoantibody response.
Q90214474Antigenicity of tissues and organs from GGTA1/CMAH/β4GalNT2 triple gene knockout pigs
Q56890337B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy
Q64900187B4GALNT2 and xenotransplantation: A newly appreciated xenogeneic antigen.
Q35012361Bortezomib, C1-inhibitor and plasma exchange do not prolong the survival of multi-transgenic GalT-KO pig kidney xenografts in baboons
Q34674815Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen
Q34376068Control of IBMIR in neonatal porcine islet xenotransplantation in baboons
Q36386394Current status of pig heart xenotransplantation
Q34674677Development of a consensus protocol to quantify primate anti-non-Gal xenoreactive antibodies using pig aortic endothelial cells
Q34185181Double transgenic pigs with combined expression of human α1,2-fucosyltransferase and α-galactosidase designed to avoid hyperacute xenograft rejection
Q37519520Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein.
Q47670138Effect of TNF-alpha blockade on coagulopathy and endothelial cell activation in xenoperfused porcine kidneys
Q37050158Efficient production of multi-modified pigs for xenotransplantation by 'combineering', gene stacking and gene editing
Q47643792Encouraging experience using multi-transgenic xenografts in a pig-to-baboon cardiac xenotransplantation model.
Q88059174Examining the Biosynthesis and Xenoantigenicity of Class II Swine Leukocyte Antigen Proteins
Q45994592First quantification of alpha-Gal epitope in current glutaraldehyde-fixed heart valve bioprosthesis (by Naso et al.).
Q90529783Generation by somatic cell nuclear transfer of GGTA1 knockout pigs expressing soluble human TNFRI-Fc and human HO-1
Q34018912Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection
Q28081993Immunobiological barriers to xenotransplantation
Q33440243Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts.
Q36828449Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs
Q93227584Is Transgenic Porcine Skin as Good as Allogeneic Skin for Regenerative Medicine? Comparison of Chosen Properties of Xeno- and Allogeneic Material
Q26822638Kidney xenotransplantation
Q48132200Low anti-pig antibody levels are key to the success of solid organ xenotransplantation: But is this sufficient?
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Q91681745Perspectives on the Optimal Genetically Engineered Pig in 2018 for Initial Clinical Trials of Kidney or Heart Xenotransplantation
Q47136558Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?
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Q34020948Rhesus monkeys and baboons develop clotting factor VIII inhibitors in response to porcine endothelial cells or islets
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Q90496748Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival
Q38019009Xenotransplantation literature update, March to April 2012.
Q89621137Xenotransplantation: Current Status in Preclinical Research
Q38187179Xenotransplantation: immunological hurdles and progress toward tolerance

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