Double transgenic pigs with combined expression of human α1,2-fucosyltransferase and α-galactosidase designed to avoid hyperacute xenograft rejection

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Double transgenic pigs with combined expression of human α1,2-fucosyltransferase and α-galactosidase designed to avoid hyperacute xenograft rejection is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1001161754
P356DOI10.1007/S00005-014-0280-3
P932PMC publication ID4164832
P698PubMed publication ID24554032
P5875ResearchGate publication ID260271650

P50authorRyszard SłomskiQ18670230
Wojciech JuzwaQ57044420
Joanna ZeylandQ61108238
Marlena SzalataQ73450559
Daniel LipińskiQ77066092
Barbara GawrońskaQ86972133
Urszula MazurekQ87903141
P2093author name stringAgnieszka Nowak
Anna Woźniak
Zdzisław Smorąg
Jacek Jura
P2860cites workMolecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigenQ24321389
Clinical lung xenotransplantation--what donor genetic modifications may be necessary?Q26823663
alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 monthsQ28193880
Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopesQ28367491
Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantationQ34035421
Xenotransplantation of Galactosyl-Transferase Knockout, CD55, CD59, CD39, and Fucosyl-Transferase Transgenic Pig Kidneys Into BaboonsQ60405540
Standard karyotype of the domestic pig. Committee for the Standardized Karyotype of the Domestic PigQ68039412
Distribution of glycosyltransferases among Golgi apparatus subfractions from liver and hepatomas of the ratQ68329320
Molecular executors of cell death--differential intrarenal expression of Fas ligand, Fas, granzyme B, and perforin during acute and/or chronic rejection of human renal allograftsQ71961157
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experienceQ81199195
[Why humans and Catarrhini lack the Galalpha1-3Gal epitope, related to xenograft rejection?]Q84014807
Genetic engineering of the donor as an approach to clinical xenotransplantationQ34116605
A brief history of cross-species organ transplantationQ34249549
Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneysQ34480315
Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenograftsQ35857059
Complete absence of the αGal xenoantigen and isoglobotrihexosylceramide in α1,3galactosyltransferase knock-out pigs.Q36734731
Combined transgenic expression of alpha-galactosidase and alpha1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galalpha(1,3)GalQ36829733
Transgenic pigs designed to express human α-galactosidase to avoid humoral xenograft rejectionQ37039345
Xenotransplantation of solid organs in the pig-to-primate modelQ37309853
Antibody-mediated xenograft injury: mechanisms and protective strategiesQ37450148
Pig-to-nonhuman primate islet xenotransplantationQ37475745
Genetic modification of pigs for solid organ xenotransplantation.Q37815273
Alpha-Gal detectors in xenotransplantation research: a word of caution.Q38036376
Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis.Q38288887
Characterization of cartilage from H-transferase transgenic pigsQ39997403
Pig xenogeneic antigen modification with green coffee bean alpha-galactosidaseQ40895910
Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation.Q42287167
Heterogeneity of human anti-pig natural antibodies cross-reactive with the Gal(alpha1,3)Galactose epitopeQ42547963
The methods to generate transgenic animals and to control transgene expressionQ44079492
Expression of human alpha-galactosidase and alpha1,2-fucosyltransferase genes modifies the cell surface Galalpha1,3Gal antigen and confers resistance to human serum-mediated cytolysisQ44855716
Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissueQ45201952
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P921main subjectxenograftQ64148587
P304page(s)411-422
P577publication date2014-02-20
P1433published inArchivum Immunologiae et Therapiae ExperimentalisQ15760838
P1476titleDouble transgenic pigs with combined expression of human α1,2-fucosyltransferase and α-galactosidase designed to avoid hyperacute xenograft rejection
P478volume62