Xenotransplantation of solid organs in the pig-to-primate model

scientific article published on 26 October 2008

Xenotransplantation of solid organs in the pig-to-primate model is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/J.TRIM.2008.10.005
P698PubMed publication ID18955143

P50authorDavid K. C. CooperQ87755223
P2093author name stringBruno Gridelli
Burcin Ekser
Paolo Rigotti
P2860cites workalpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 monthsQ28193880
Increased immunosuppression, not anticoagulation, extends cardiac xenograft survivalQ28213664
Viable offspring derived from fetal and adult mammalian cellsQ28304072
Absence of replication-competent human-tropic porcine endogenous retroviruses in the germ line DNA of inbred miniature SwineQ31047713
Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantationQ33342998
Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. The XEN 111 Study GroupQ33871594
Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutationsQ33904933
Cloned pigs produced by nuclear transfer from adult somatic cellsQ33918147
Production of alpha 1,3-galactosyltransferase-deficient pigsQ33963251
Xenotransplantation of the liverQ34170336
Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejectionQ34315275
Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneysQ34480315
A human CD46 transgenic pig model system for the study of discordant xenotransplantationQ34513633
Incidence of hyperacute rejection in pig-to-primate transplantation using organs from hDAF-transgenic donorsQ34608583
Animal transgenesis: state of the art and applicationsQ34608788
Xenotransplantation: infectious risk revisitedQ35861536
Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejectionQ35898992
The utility of right ventricular endomyocardial biopsy for the diagnosis of xenograft rejection after CD46 pig-to-baboon cardiac transplantation.Q36183720
Pigs taking wing with transposons and recombinases.Q36187528
Carbohydrates in xenotransplantation.Q36201681
Pathology of renal xenograft rejection in pig to non-human primate transplantationQ36539624
Selected physiologic compatibilities and incompatibilities between human and porcine organ systemsQ36632325
Progress in xenotransplantation following the introduction of gene-knockout technologyQ36713339
Pig-to-non-human primate heart transplantation: immunologic progress over 20 yearsQ36754966
Alpha1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here?Q36878996
An update on xenotransplantationQ36903599
Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature SwineQ36954781
Reappraisal of biosafety risks posed by PERVs in xenotransplantationQ36995344
Liver xenografts for the treatment of acute liver failure: clinical and experimental experience and remaining immunologic barriersQ37126193
Xenotransplantation: where are we in 2008?Q37140607
Coagulation cascade activation triggers early failure of pig hearts expressing human complement regulatory genesQ79532880
Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantationQ80020967
Antibodies directed to pig non-Gal antigens in naïve and sensitized baboonsQ80152150
The pig-to-primate immune response: relevance for xenotransplantationQ80298006
Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboonsQ80435544
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experienceQ81199195
Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infantsQ81238227
The coagulation barrier in xenotransplantation: incompatibilities and strategies to overcome them.Q37236863
Shear-induced platelet aggregationQ37582206
Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis.Q38288887
Evaluation of different alpha-Galactosyl glycoconjugates for use in xenotransplantationQ38289265
Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humansQ38312428
Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swineQ39321537
Discordant organ xenotransplantation in primates: world experience and current statusQ40841815
Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man.Q42275309
Cytomegalovirus early promoter induced expression of hCD59 in porcine organs provides protection against hyperacute rejection.Q42820266
C1-Inhibitor for treatment of acute vascular xenograft rejection in cynomolgus recipients of h-DAF transgenic porcine kidneysQ43818418
The alpha-Gal analog GAS914 ameliorates delayed rejection of hDAF transgenic pig-to-baboon renal xenograftsQ43828706
Serum anti-pig antibodies as potential indicators of acute humoral xenograft rejection in pig-to-cynomolgus monkey kidney transplantationQ43940368
Assessment of renal function during the postoperative period following liver xenotransplantation from transgenic pig to baboon.Q43963140
Prolonged function of extracorporeal hDAF transgenic pig livers perfused with human bloodQ43974590
Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to plateletsQ44139530
Life-supporting human complement regulator decay accelerating factor transgenic pig liver xenograft maintains the metabolic function and coagulation in the nonhuman primate for up to 8 days.Q44304002
Pig-to-baboon liver xenograftsQ44852598
Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.Q45171019
Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissueQ45201952
Administration of GAS914 in an orthotopic pig-to-baboon heart transplantation modelQ45252437
Cardiac xenotransplantation: recent preclinical progress with 3-month median survivalQ46695733
Recent advances in pig-to-human organ and cell transplantationQ46849311
The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of hDAF transgenic porcine kidneys in baboons receiving anti-Gal antibody neutralization therapyQ46911711
Classical pathway complement destruction is not responsible for the loss of human erythrocytes during porcine liver perfusionQ47418935
Life-supporting pig-to-primate renal xenotransplantation using genetically modified donorsQ47842680
Orthotopic heart transplantation in a transgenic pig-to-primate model.Q47842697
Alterations in the coagulation profile in renal pig-to-monkey xenotransplantation.Q51038598
Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs.Q52919756
Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts.Q53664360
Prevention of Hyperacute Rejection in a Model of Orthotopic Liver Xenotransplantation From Pig to Baboon Using Polytransgenic Pig Livers (CD55, CD59, and H-Transferase)Q57583770
Genetically engineered pigsQ72230307
Mechanisms of resistance to injury in pig livers perfused with blood from patients in liver failureQ73279753
Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsivenessQ73459820
Life supporting function for over one month of a transgenic porcine heart in a baboonQ73513215
The role of antibodies and von Willebrand factor in discordant pulmonary xenotransplantationQ73810362
Delayed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapyQ73884179
HDAF transgenic pig livers are protected from hyperacute rejection during ex vivo perfusion with human bloodQ74070801
Non-anti-Gal alpha1-3Gal antibody mechanisms are sufficient to cause hyperacute lung dysfunction in pulmonary xenotransplantationQ74350187
Analysis of the control of the anti-gal immune response in a non-human primate by galactose alpha1-3 galactose trisaccharide-polyethylene glycol conjugateQ74365695
Physiological aspects of pig-to-primate renal xenotransplantationQ74566890
Cyclophosphamide-induced postoperative anemia in cynomolgus monkey recipients of hDAF-transgenic pig organ xenograftsQ74604864
Three-month survival of HDAFF transgenic pig hearts transplanted into primatesQ74616950
Anti-CD154 monoclonal antibody and thromboembolism revistedQ74622610
Treatment with rabbit antithymocyte serum permits a cyclophosphamide-free approach to prevention of hDAF transgenic porcine kidney xenograft rejection in baboonsQ77370557
Complement activation in discordant hepatic xenotransplantationQ77895161
Extended coagulation profiles of healthy baboons and of baboons rejecting GT-KO pig heart graftsQ79293143
P433issue2
P921main subjectpigQ787
primateQ7380
P304page(s)87-92
P577publication date2008-10-26
P1433published inTransplant ImmunologyQ15758510
P1476titleXenotransplantation of solid organs in the pig-to-primate model
P478volume21

Reverse relations

cites work (P2860)
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