Haploinsufficiency of yeast FEN1 causes instability of expanded CAG/CTG tracts in a length-dependent manner

scientific article published on 12 February 2007

Haploinsufficiency of yeast FEN1 causes instability of expanded CAG/CTG tracts in a length-dependent manner is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.GENE.2007.01.025
P932PMC publication ID1904339
P698PubMed publication ID17383831
P5875ResearchGate publication ID6423370

P2093author name stringJiahui Yang
Catherine H Freudenreich
P2860cites workEpitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routinesQ28131620
Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeatsQ28142629
Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stabilityQ28146137
Huntington disease expansion mutations in humans can occur before meiosis is completedQ30962381
Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths.Q33869149
Trinucleotide repeat instability: a hairpin curve at the crossroads of replication, recombination, and repairQ35550042
The contribution of <i>cis</i>-elements to disease-associated repeat instability: clinical and experimental evidenceQ35550046
Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instabilityQ35661319
Replication fork dynamics and dynamic mutations: the fork-shift model of repeat instabilityQ36105938
Repeat instability: mechanisms of dynamic mutationsQ36277189
Lagging strand replication proteins in genome stability and DNA repairQ36389646
Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stabilityQ37424442
DNA ligase I competes with FEN1 to expand repetitive DNA sequences in vitroQ38290311
Mutations in Yeast Replication Proteins That Increase CAG/CTG Expansions Also Increase Repeat FragilityQ39940361
Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genomeQ40021880
Candidate DNA replication initiation regions at human trinucleotide repeat disease lociQ40654698
Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansionQ44294677
Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesisQ44626605
Structure-forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: implications for trinucleotide repeat expansion diseasesQ45295085
Trinucleotide expansion in haploid germ cells by gap repairQ45302664
Assay of yeast mating reactionQ46855519
Flap endonuclease homologs in archaebacteria exist as independent proteins.Q47613813
Dramatic, expansion-biased, age-dependent, tissue-specific somatic mosaicism in a transgenic mouse model of triplet repeat instability.Q52918724
Fen1 does not control somatic hypermutability of the (CTG)(n)*(CAG)(n) repeat in a knock-in mouse model for DM1.Q53599152
Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coliQ54611269
Yeast cell-type regulation of DNA repairQ57579918
Sensitivity of a S. cerevisiae RAD27 deletion mutant to DNA-damaging agents and in vivo complementation by the human FEN-1 geneQ73135068
Repeat expansion--all in a flap?Q73388102
Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansionQ73626789
Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturationQ73911234
Expansion and length-dependent fragility of CTG repeats in yeastQ74128701
Neurodegenerative diseases. Origins of instabilityQ74220077
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjecthaploinsufficiencyQ852654
P304page(s)110-115
P577publication date2007-02-12
P1433published inGeneQ5531065
P1476titleHaploinsufficiency of yeast FEN1 causes instability of expanded CAG/CTG tracts in a length-dependent manner
P478volume393

Reverse relations

cites work (P2860)
Q34712058A 5', 8-cyclo-2'-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β
Q36457201ATR protects the genome against CGG.CCG-repeat expansion in Fragile X premutation mice
Q37584997Abnormal base excision repair at trinucleotide repeats associated with diseases: a tissue-selective mechanism
Q35943348Altered replication in human cells promotes DMPK (CTG)(n) · (CAG)(n) repeat instability
Q37680431Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion
Q37446749CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair
Q34121171Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats
Q35881868DNA base excision repair: a mechanism of trinucleotide repeat expansion.
Q34477635Defining Genetic Factors That Modulate Intergenerational CAG Repeat Instability inDrosophila melanogaster
Q37687363Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes
Q27939094Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity
Q42086935Expansion of CAG repeats in Escherichia coli is controlled by single-strand DNA exonucleases of both polarities.
Q37593054Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age.
Q89499950FAN1 protects against repeat expansions in a Fragile X mouse model
Q34559690Functional regulation of FEN1 nuclease and its link to cancer
Q35847997Instability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesis
Q34182956Potassium bromate, a potent DNA oxidizing agent, exacerbates germline repeat expansion in a fragile X premutation mouse model
Q35680075Repeat instability during DNA repair: Insights from model systems
Q42177075Replication-dependent instability at (CTG)•(CAG) repeat hairpins in human cells
Q59132715SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress
Q36409202Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.
Q30972892Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice
Q36580985Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1.

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