Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton.

scientific article published on 26 March 2012

Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.201110127
P932PMC publication ID3317799
P698PubMed publication ID22451697
P5875ResearchGate publication ID221983156

P50authorAndrea K H StavoeQ83750703
P2093author name stringDaniel A Colón-Ramos
P2860cites workActivation of Rac1 by a Crk SH3-binding protein, DOCK180Q22007972
The Structure of the Nervous System of the Nematode Caenorhabditis elegansQ22337105
Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formationQ24312204
Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processesQ24596003
Guidance molecules in synapse formation and plasticityQ24614257
Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegansQ24657430
The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegansQ28182033
Netrins and netrin receptorsQ28201850
Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansionQ28577458
Remodeling of synaptic actin induced by photoconductive stimulationQ43815517
Developmentally regulated changes in cellular compartmentation and synaptic distribution of actin in hippocampal neuronsQ44125007
SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.Q45958930
Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial functions of netrins, semaphorins, and IgCAMs.Q46053403
UNC-115, a conserved protein with predicted LIM and actin-binding domains, mediates axon guidance in C. elegansQ46103419
C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal developmentQ46324959
The netrin receptor UNC-40/DCC stimulates axon attraction and outgrowth through enabled and, in parallel, Rac and UNC-115/AbLIM.Q46349589
The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in DrosophilaQ46404564
Identification of genes involved in synaptogenesis using a fluorescent active zone marker in Caenorhabditis elegans.Q46437151
SYD-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains, specifies axon identity in C. elegansQ46453307
A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegansQ47068679
Wnt signaling positions neuromuscular connectivity by inhibiting synapse formation in C. elegansQ47068936
Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis.Q47069113
Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans.Q47069270
The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C. elegansQ47069372
Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans.Q47069421
Mutations affecting embryonic cell migrations in Caenorhabditis elegansQ47069580
Wnt4 is a local repulsive cue that determines synaptic target specificityQ47070731
UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegansQ48151727
Actin has a molecular scaffolding, not propulsive, role in presynaptic functionQ48405526
Stages of synapse development defined by dependence on F-actin.Q48822724
Mosaic analysis in the nematode Caenorhabditis elegansQ80415277
MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrinQ83161524
The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanismQ30165268
Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signalingQ30443470
Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP.Q30477376
UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegansQ30485805
Versatile fluorescent probes for actin filaments based on the actin-binding domain of utrophinQ30629061
Visualization of synaptic specializations in live C. elegans with synaptic vesicle protein-GFP fusionsQ30767423
Functions of axon guidance molecules in synapse formationQ33615279
Axon guidance: asymmetric signaling orients polarized outgrowth.Q33854522
A conserved mechanism of synaptogyrin localizationQ33944046
The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegansQ34308728
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.Q34332258
Netrin signaling leading to directed growth cone steering.Q34606429
UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendritesQ34822844
A conserved juxtacrine signal regulates synaptic partner recognition in Caenorhabditis elegansQ35089098
Investigating C. elegans development through mosaic analysisQ35210615
The actin cytoskeleton: integrating form and function at the synapseQ36200197
Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance.Q36498043
Association of Rab3A with synaptic vesicles at late stages of the secretory pathwayQ36530411
Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junctionQ37003808
Functions of Rac GTPases during neuronal development.Q37030405
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacyQ37143121
Wnt signaling in neural circuit assemblyQ37193044
Molecular mechanisms of presynaptic differentiationQ37202824
CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.Q37242270
Rapid assembly of functional presynaptic boutons triggered by adhesive contactsQ37361929
Netrin participates in the development of retinotectal synaptic connectivity by modulating axon arborization and synapse formation in the developing brainQ37416203
Hierarchical assembly of presynaptic components in defined C. elegans synapsesQ37566924
Cellular signaling of Dock family proteins in neural functionQ37606708
Cytoskeletal dynamics in growth-cone steering.Q37610679
Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cellsQ38292096
The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1.Q39454809
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegansQ39749591
UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formationQ40345230
The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegansQ41695648
Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborizationQ43056598
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
Uncharacterized protein CELE_C02F4.1Q29796453
P1104number of pages14
P304page(s)75-88
P577publication date2012-03-26
P1433published inJournal of Cell BiologyQ1524550
P1476titleNetrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton
P478volume197

Reverse relations

cites work (P2860)
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Q37618684MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans
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Q41882631Synapse location during growth depends on glia location
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Q24296506mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking

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