An Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis

scientific article published on 16 December 2015

An Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1045067H
P356DOI10.1371/JOURNAL.PONE.0145067
P932PMC publication ID4684495
P698PubMed publication ID26674348
P5875ResearchGate publication ID287213132

P2093author name stringNobuhiko Katunuma
Chihiro Kondo
Yoko Hashimoto
P2860cites workElectron microscopy of lysosomerich fractions from rat liverQ24655052
Mammalian GGAs act together to sort mannose 6-phosphate receptorsQ24672154
The lysosome: from waste bag to potential therapeutic targetQ27022248
Endo-beta-N-acetylglucosaminidase acting on carbohydrate moieties of glycoproteins. Purification and properties of the enzyme from Diplococcus pneumoniaeQ28237269
Inhibition of glioma cell lysosome exocytosis inhibits glioma invasionQ28484152
Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomesQ28572060
Lysosomal enzyme phosphorylation. Recognition of a protein-dependent determinant allows specific phosphorylation of oligosaccharides present on lysosomal enzymesQ28573945
Identification of latent procathepsins B and L in microsomal lumen: characterization of enzymatic activation and proteolytic processing in vitroQ68265043
Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophagesQ68325548
Chymostatin, a new chymotrypsin inhibitor produced by actinomycetesQ71527152
Kinetics of the pH-induced inactivation of human cathepsin LQ72067273
Specific assay method for the activities of cathepsin L-type cysteine proteinasesQ72411002
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivoQ73077056
Bi-directional trafficking between the trans-Golgi network and the endosomal/lysosomal systemQ73821934
Surface activation of pro-cathepsin LQ28592047
Lysosomal exocytosis and lipid storage disordersQ33653667
Regulated secretion of conventional lysosomesQ33960468
Causes and effects of heterogeneous perfusion in tumorsQ33997836
Transcriptional activation of lysosomal exocytosis promotes cellular clearanceQ35214694
Destination 'lysosome': a target organelle for tumour cell killing?Q35549436
Cathepsin B and its role(s) in cancer progressionQ35572269
Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cellsQ36274042
Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic beta-cellsQ36274102
Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cellsQ36323778
The tumor microenvironment and metastatic diseaseQ37187529
Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cellsQ37296811
Protein determinants impair recognition of procathepsin L phosphorylated oligosaccharides by the cation-independent mannose 6-phosphate receptor.Q38340055
Basis for low affinity binding of a lysosomal cysteine protease to the cation-independent mannose 6-phosphate receptor.Q38341571
Trafficking of lysosomal enzymes in normal and disease statesQ38351553
Significance of 32-kDa cathepsin L secreted from cancer cellsQ40242131
Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.Q40560262
Inhibitory Effect of the .ALPHA.1-Antitrypsin Pittsburgh Type-Mutant(.ALPHA.1-PIM/R) on Proinsulin Processing in the Regulated Secretory Pathway of the Pancreatic .BETA.-Cell Line MIN6Q40649680
Exocytosis of active cathepsin B enzyme activity at pH 7.0, inhibition and molecular massQ40935441
Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissueQ41845012
Glycosylation of procathepsin L does not account for species molecular-mass differences and is not required for proteolytic activityQ42795813
Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritisQ43591458
Protein sorting by selective retention in the endoplasmic reticulum and Golgi stackQ44674838
Demonstration of an endo-glycosidase acting on a glycoproteinQ44742075
Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs.Q44814891
Endo-beta-N-acetylglucosaminidases acting on the carbohydrate moieties of glycoproteins. The differential specificities of the enzymes from Streptomyces griseus and Diplococcus pneumoniaeQ45198948
Molecular cloning and sequencing of cDNA for rat cathepsin L.Q48336760
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectexocytosisQ323426
P304page(s)e0145067
P577publication date2015-12-16
P1433published inPLOS OneQ564954
P1476titleAn Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis
P478volume10

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cites work (P2860)
Q89634052A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L
Q57461457Cathepsin L Causes Proteolytic Cleavage of CHO Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation
Q64069431Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment
Q90290679Cysteine Cathepsins in Tumor-Associated Immune Cells
Q52573372Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials.
Q52665178Gelatin Zymography Using Leupeptin for the Detection of Various Cathepsin L Forms.
Q97557237The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management
Q47243896Transcriptome signature identifies distinct cervical pathways induced in LPS-mediated preterm birth.

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