Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform

scientific article published in August 1996

Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.1996.TB15589.X
P932PMC publication ID1909818
P698PubMed publication ID8842429
P5875ResearchGate publication ID14363835

P2093author name stringR Bryk
A L Salzman
C Szabó
B Zingarelli
V Bhat
D J Wolff
G J Southan
T C Gahman
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Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heartQ35980011
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthaseQ35986312
Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthaseQ36364285
Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic miceQ36686163
DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitriteQ37700756
Alterations in nitric oxide production in various forms of circulatory shockQ40399410
Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoformQ41233331
Differential regulation of constitutive and inducible nitric oxide production by inflammatory stimuli in murine endothelial cellsQ41454463
The inhibition of the constitutive and inducible nitric oxide synthase isoforms by indazole agentsQ41466305
Inhibition of nitric oxide formation by guanidinesQ41514913
Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharideQ41558166
Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivityQ42068720
Identification and characterization of a calmodulin-dependent nitric oxide synthase from GH3 pituitary cellsQ42074592
Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureasQ42275346
Nitric oxide synthesis in the CNS, endothelium and macrophages differs in its sensitivity to inhibition by arginine analoguesQ44221658
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Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation.Q48189007
Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginineQ48231585
Dexamethasone prevents vascular failure mediated by nitric oxide in hemorrhagic shock.Q49326969
NG-Methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthaseQ64921353
Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginineQ68857714
Metabolism and radioprotective effect of AET and MEG in organismQ69657010
Inactivation of nitric oxide synthase isoforms by diaminoguanidine and NG-amino-L-arginineQ70899975
Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoformQ71289429
The inhibition of the constitutive bovine endothelial nitric oxide synthase by imidazole and indazole agentsQ71659624
Aminoguanidine is an isoform-selective, mechanism-based inactivator of nitric oxide synthaseQ71671331
Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivoQ71691440
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthaseQ71694221
N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthasesQ71698622
Chemical protection against ionizing radiation. II. Mercaptoalkylamines and related compounds with protective activityQ74582617
THE MECHANISM OF ACTION OF AET. V. THE DISTRIBUTION AND THE CHEMICAL FORMS OF 2-MERCAPTOETHYLGUANIDINE AND BIS (2-GUANIDOETHYL) DISULFIDE GIVEN ORALLY IN PROTECTIVE DOSES TO MICEQ76557653
The protection of mice against radiation by 2-mercaptoethylguanidine and its disulfideQ79025784
The mechanism of action of AET. IV. The distribution and the chemical forms of 2-mercaptoethylguanidine and bis(2-guanidoethyl) disulfide in protected miceQ79615283
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)1659-1668
P577publication date1996-08-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titlePharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform
P478volume118

Reverse relations

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