The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity

scientific article published on February 1997

The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.BJP.0700892
P932PMC publication ID1564467
P698PubMed publication ID9031736
P5875ResearchGate publication ID14178195

P2093author name stringSzabó C
O'Connor M
Salzman AL
Zingarelli B
Gilad E
Southan GJ
P2860cites workIsothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivityQ42068720
Endogenous nitric oxide increases prostaglandin biosynthesis in carrageenin rat paw oedema.Q50756412
The non specificity of specific nitric oxide synthase inhibitorsQ67542879
Nitric oxide mediates interleukin-1-induced prostaglandin E2 production by vascular smooth muscle cellsQ70466078
IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxideQ71603840
Nitric oxide modulates prostacyclin biosynthesis in the lung of endotoxin-treated ratsQ71666899
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitroQ72321250
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenaseQ24563699
Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammationQ24564394
Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitorsQ28367719
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluidsQ29616817
Selective pharmacological inhibition of distinct nitric oxide synthase isoformsQ34377795
Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoidsQ34792988
Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide synthase by endotoxin in cultured cellsQ34793764
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenicQ35163045
The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthaseQ35873190
Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoformQ35873994
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthaseQ35986312
Nitric oxide activates cyclooxygenase enzymes.Q36457941
Prostaglandin and thromboxane biosynthesisQ37339535
Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammationQ40336245
Cyclooxygenase-2: regulation and relevance in inflammationQ40384073
Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoformQ41233331
Inhibition of nitric oxide formation by guanidinesQ41514913
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)357-366
P577publication date1997-02-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleThe inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity
P478volume120

Reverse relations

cites work (P2860)
Q73962333Amelioration by mercaptoethylguanidine of the vascular and energetic failure in haemorrhagic shock in the anesthetised rat
Q74075555Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation
Q44894316Effect of inducible cyclooxygenase expression on local microvessel blood flow in acute interstitial pancreatitis
Q37370840Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite
Q44322839Enhanced expression of inducible nitric oxide synthase without vasodilator effect in chronically infected lungs
Q28213026Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats
Q33567203Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia
Q35028682Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of alpha1-antiproteinase by mercaptoethylguanidine
Q36698125Molecular mechanisms involved in the reciprocal regulation of cyclooxygenase and nitric oxide synthase enzymes
Q34019768Nitric oxide and intestinal inflammation
Q34252179Nitric oxide and tissue destruction
Q46889696Peroxisome proliferator activated receptor gamma is not necessary for the development of LPS-induced tolerance in macrophages
Q33836818Peroxynitrite and inflammatory bowel disease
Q31803441Potentiation by aminoethylisothiourea of the extra-cellular Ca(2+) component of norepinephrine-induced contraction in rat femoral arteries
Q35027125Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat.
Q26852195Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications
Q36066240Role of COX-2 in microcirculatory disturbance in experimental pancreatitis
Q43545279Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury
Q46428215Scavenging of peroxynitrite reduces renal ischemia/reperfusion injury
Q41534673Selective inhibitors of neuronal nitric oxide synthase--is no NOS really good NOS for the nervous system?
Q31432554Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice.
Q33709258The inducible nitric oxide synthase in vascular and cardiac tissue
Q54251646Thiazoles and Thiazolidinones as COX/LOX Inhibitors.
Q46620938Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}.

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