| scholarly article | Q13442814 |
| P356 | DOI | 10.1242/DEV.125492 |
| P8608 | Fatcat ID | release_cyfqvzynfbbc3hyefnz6btwwye |
| P932 | PMC publication ID | 4510869 |
| P698 | PubMed publication ID | 26062937 |
| P50 | author | Raphael Kopan | Q41898306 |
| Andrew Zhang | Q87012136 | ||
| P2093 | author name string | Chi Zhang | |
| Mitsuru Morimoto | |||
| Zhenyi Liu | |||
| Patrick Y Jay | |||
| Barbara Varnum-Finney | |||
| Eric Brunskill | |||
| Irv Bernstein | |||
| P2860 | cites work | Mapping and quantifying mammalian transcriptomes by RNA-Seq | Q22122035 |
| Mutations in NOTCH1 cause aortic valve disease | Q24307999 | ||
| Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover | Q24315524 | ||
| Notch signaling controls multiple steps of pancreatic differentiation | Q24569636 | ||
| Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1 | Q24670708 | ||
| Coordinating tissue interactions: Notch signaling in cardiac development and disease | Q26822995 | ||
| Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity | Q27333237 | ||
| A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency | Q28203380 | ||
| The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development | Q28508689 | ||
| Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes | Q28510729 | ||
| Notch1 is required for the coordinate segmentation of somites | Q28513676 | ||
| gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis | Q28591384 | ||
| Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway | Q28592687 | ||
| Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells | Q28594415 | ||
| Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL | Q28594519 | ||
| Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation | Q28646236 | ||
| The canonical Notch signaling pathway: unfolding the activation mechanism | Q29547725 | ||
| Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis | Q29614939 | ||
| Notch1 functions as a tumor suppressor in mouse skin | Q29614987 | ||
| Notch signaling is essential for vascular morphogenesis in mice | Q29620377 | ||
| Cis-interactions between Notch and Delta generate mutually exclusive signalling states | Q30494896 | ||
| Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. | Q30497988 | ||
| Loss of NOTCH2 positively predicts survival in subgroups of human glial brain tumors | Q33288968 | ||
| Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation | Q34077697 | ||
| Heterogeneity of genetic modifiers ensures normal cardiac development | Q34193363 | ||
| Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development | Q34197865 | ||
| Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses | Q34375200 | ||
| Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. | Q34415366 | ||
| Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells | Q34627216 | ||
| Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells | Q34760390 | ||
| Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. | Q35000965 | ||
| Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells | Q35031614 | ||
| Jagged-Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype | Q35062669 | ||
| Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency | Q35177762 | ||
| Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity | Q35178905 | ||
| Genetic architecture of mouse skin inflammation and tumour susceptibility | Q35702641 | ||
| A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse | Q35729853 | ||
| Models for peripheral B cell development and homeostasis. | Q36096530 | ||
| Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow | Q36369594 | ||
| Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells | Q36403591 | ||
| Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1 | Q36421137 | ||
| Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells | Q36432890 | ||
| Notch signaling represses p63 expression in the developing surface ectoderm | Q37124587 | ||
| Notch signaling in cardiac development and disease. | Q37382226 | ||
| IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity. | Q37397830 | ||
| Regulation of Notch signaling during T- and B-cell development by O-fucose glycans | Q37548662 | ||
| A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal | Q37582286 | ||
| Mechanistic insights into Notch receptor signaling from structural and biochemical studies | Q37785192 | ||
| Gamma-secretase and the intramembrane proteolysis of Notch | Q37785197 | ||
| Notch signaling in cardiac development and disease. | Q37785202 | ||
| From Notch signaling to fine-grained patterning: Modeling meets experiments | Q37921440 | ||
| Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies | Q39929085 | ||
| Notch1 and notch2 have opposite effects on embryonal brain tumor growth | Q40497328 | ||
| Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase. | Q40686455 | ||
| Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. | Q41826001 | ||
| Epidermal ADAM17 is dispensable for notch activation | Q42064860 | ||
| CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling. | Q42492223 | ||
| Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting | Q42876374 | ||
| Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress. | Q43118025 | ||
| Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. | Q43213014 | ||
| Deficient T cell fate specification in mice with an induced inactivation of Notch1. | Q45345200 | ||
| The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis | Q45345843 | ||
| Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. | Q45345845 | ||
| Opposite effects of Notch-1 and Notch-2 on mesothelioma cell survival under hypoxia are exerted through the Akt pathway | Q46220467 | ||
| Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells | Q47640438 | ||
| Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice. | Q51951782 | ||
| The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. | Q52040186 | ||
| Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer. | Q53289449 | ||
| The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. | Q54696809 | ||
| A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea | Q73849637 | ||
| P433 | issue | 14 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | carcinogenesis | Q1637543 |
| P1104 | number of pages | 12 | |
| P304 | page(s) | 2452-2463 | |
| P577 | publication date | 2015-06-10 | |
| P1433 | published in | Development | Q3025404 |
| P1476 | title | The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis | |
| P478 | volume | 142 |
| Q42327466 | Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation |
| Q57109688 | Crosstalk between Notch, HIF-1α and GPER in Breast Cancer EMT |
| Q47291991 | Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer. |
| Q39597373 | Developing HSCs become Notch independent by the end of maturation in the AGM region |
| Q50426445 | Do as I say, Not(ch) as I do: Lateral control of cell fate. |
| Q41828280 | Downregulation of leptin inhibits growth and induces apoptosis of lung cancer cells via the Notch and JAK/STAT3 signaling pathways |
| Q50526776 | Effects of the Notch1 signaling pathway on human lung cancer A549 cells. |
| Q96950706 | Enhanced Notch3 signaling contributes to pulmonary emphysema in a Murine Model of Marfan syndrome |
| Q89976617 | Hear, Hear for Notch: Control of Cell Fates in the Inner Ear by Notch Signaling |
| Q99553768 | IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation |
| Q52653382 | Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis. |
| Q83226295 | Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation |
| Q94586315 | MiR-153 reduces stem cell-like phenotype and tumor growth of lung adenocarcinoma by targeting Jagged1 |
| Q89235892 | Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis |
| Q36960089 | Notch Signaling and the Skeleton |
| Q46795621 | Notch Signaling in Development, Tissue Homeostasis, and Disease |
| Q39141059 | Notch Signaling in Vascular Smooth Muscle Cells |
| Q89725071 | Notch Signalling: The Multitask Manager of Inner Ear Development and Regeneration |
| Q47428777 | Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation |
| Q90714490 | Notch signaling in the mammalian respiratory system, specifically the trachea and lungs, in development, homeostasis, regeneration, and disease |
| Q38923306 | Notch signalling in context |
| Q89771836 | Overview of Basic Mechanisms of Notch Signaling in Development and Disease |
| Q90614430 | Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens |
| Q92904617 | Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway |
| Q33790752 | Selective regulation of Notch ligands during angiogenesis is mediated by vimentin |
| Q48311397 | Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome |
| Q96641277 | Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity |
| Q37284219 | The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development |
| Q56979776 | The ectodomains determine ligand function and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 |
| Q38747422 | The role of Notch signaling in the mammalian ovary |
| Q92889047 | The role of oncogenic Notch2 signaling in cancer: a novel therapeutic target |
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