| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1027338305 |
| P356 | DOI | 10.1186/S12943-015-0399-9 |
| P8608 | Fatcat ID | release_f6zj5cwl3fbvpf77azzs6vtqp4 |
| P932 | PMC publication ID | 4511243 |
| P698 | PubMed publication ID | 26198749 |
| P5875 | ResearchGate publication ID | 280483189 |
| P50 | author | Evangelos Balafas | Q80455974 |
| Efthimios Paronis | Q85639672 | ||
| Dimitrios J Stravopodis | Q51900481 | ||
| Athanasios D Velentzas | Q58236611 | ||
| P2093 | author name string | Konstantinos N Syrigos | |
| Ema Anastasiadou | |||
| Nikolaos Kostomitsopoulos | |||
| Gerassimos E Voutsinas | |||
| Eumorphia G Konstantakou | |||
| Aggeliki-Stefania Basogianni | |||
| P2860 | cites work | ERK1/2-p90RSK-mediated phosphorylation of Na+/H+ exchanger isoform 1. A role in ischemic neuronal death | Q80704082 |
| Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7 | Q81924193 | ||
| Hallmarks of Cancer: The Next Generation | Q22252312 | ||
| Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase | Q24302381 | ||
| The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways | Q24302411 | ||
| Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis | Q24311815 | ||
| Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation | Q24323390 | ||
| p53 opens the mitochondrial permeability transition pore to trigger necrosis | Q24338796 | ||
| Understanding the Warburg effect: the metabolic requirements of cell proliferation | Q24604760 | ||
| The AMPK signalling pathway coordinates cell growth, autophagy and metabolism | Q24616273 | ||
| Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases | Q24632768 | ||
| Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells | Q24648994 | ||
| Identification and functional expression of the mitochondrial pyruvate carrier | Q27936768 | ||
| ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK | Q28140742 | ||
| Glycolysis inhibition for anticancer treatment | Q28256222 | ||
| The cancer cell's "power plants" as promising therapeutic targets: an overview | Q28296259 | ||
| Regulation of cancer cell metabolism | Q28303890 | ||
| Comprehensive molecular characterization of urothelial bladder carcinoma | Q28306864 | ||
| Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase | Q28366319 | ||
| Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition | Q28396983 | ||
| Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak | Q28572925 | ||
| An exonic splicing silencer is involved in the regulated splicing of glucose 6-phosphate dehydrogenase mRNA | Q28575145 | ||
| AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10 | Q28580635 | ||
| Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis | Q28654331 | ||
| Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death | Q28660873 | ||
| GammaH2AX and cancer | Q29614974 | ||
| AMPK: a nutrient and energy sensor that maintains energy homeostasis | Q29615410 | ||
| Molecular mechanisms of necroptosis: an ordered cellular explosion | Q29616004 | ||
| Identification of RIP1 kinase as a specific cellular target of necrostatins | Q29616006 | ||
| Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 | Q29616161 | ||
| Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis | Q29617725 | ||
| Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor | Q29619105 | ||
| Apoptosis: controlled demolition at the cellular level | Q29620114 | ||
| Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy | Q33572016 | ||
| Regulated necrosis: the expanding network of non-apoptotic cell death pathways. | Q34039639 | ||
| Bromopyruvate mediates autophagy and cardiolipin degradation to monolyso-cardiolipin in GL15 glioblastoma cells. | Q34154107 | ||
| Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. | Q34598646 | ||
| Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis | Q34612975 | ||
| The GLUT4 glucose transporter | Q34614833 | ||
| Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. | Q34626763 | ||
| Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond | Q34875637 | ||
| The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors | Q34993322 | ||
| zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway. | Q35092587 | ||
| The dynamic nature of autophagy in cancer | Q35393206 | ||
| Drugging the PI3 kinome: from chemical tools to drugs in the clinic. | Q35622141 | ||
| Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors | Q36111918 | ||
| Urothelial tumorigenesis: a tale of divergent pathways | Q36234720 | ||
| The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis. | Q36263013 | ||
| MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors | Q36489907 | ||
| Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization | Q36496658 | ||
| Advanced Urothelial Carcinoma: Overcoming Treatment Resistance through Novel Treatment Approaches | Q36589753 | ||
| AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress | Q36713683 | ||
| Deconvoluting the context-dependent role for autophagy in cancer | Q36876716 | ||
| Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury | Q37031838 | ||
| Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death | Q37095961 | ||
| Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer | Q37120167 | ||
| Expansion and evolution of cell death programmes | Q37139298 | ||
| Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells | Q37261134 | ||
| Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma | Q53562189 | ||
| p53 inactivation decreases dependence on estrogen/ERK signalling for proliferation but promotes EMT and susceptility to 3-bromopyruvate in ERα+ breast cancer MCF-7 cells | Q54380473 | ||
| mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation | Q54398394 | ||
| 3-bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective “small molecule” anti-cancer agent taken from labside to bedside: introduction to a special issue | Q54526090 | ||
| c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation | Q61872126 | ||
| Metabolic regulation by p53 family members. | Q37298047 | ||
| Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate | Q37316793 | ||
| Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate | Q37436821 | ||
| Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology | Q37612632 | ||
| Targeting metabolic transformation for cancer therapy. | Q37714309 | ||
| New Strategies in Muscle-Invasive Bladder Cancer: On the Road to Personalized Medicine | Q37854285 | ||
| Targeting cancer metabolism: a therapeutic window opens | Q37924094 | ||
| Molecular biomarkers in urothelial carcinoma of the bladder: are we there yet? | Q37967115 | ||
| The monocarboxylate transporter family—Role and regulation | Q37967617 | ||
| PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. | Q37974734 | ||
| Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug | Q37983497 | ||
| On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. | Q37990715 | ||
| Regulation of glucose transport by insulin: traffic control of GLUT4 | Q38012259 | ||
| New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs | Q38020082 | ||
| Endocytosis of Gene Delivery Vectors: From Clathrin-dependent to Lipid Raft-mediated Endocytosis | Q38099153 | ||
| Making new contacts: the mTOR network in metabolism and signalling crosstalk | Q38189969 | ||
| Unravelling mechanisms of p53-mediated tumour suppression | Q38205099 | ||
| RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. | Q38987871 | ||
| RIPK1- and RIPK3-induced cell death mode is determined by target availability | Q38987874 | ||
| GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death. | Q39156134 | ||
| Oncogenic Activation of Pak1-Dependent Pathway of Macropinocytosis Determines BCG Entry into Bladder Cancer Cells | Q39200090 | ||
| TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1. | Q39208867 | ||
| Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate. | Q39393508 | ||
| 3-Bromopyruvate induces endoplasmic reticulum stress, overcomes autophagy and causes apoptosis in human HCC cell lines | Q39714638 | ||
| PRIMA-1 reactivates mutant p53 by covalent binding to the core domain | Q39857551 | ||
| Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA. | Q39907305 | ||
| A mechanism for the activation of the Na/H exchanger NHE-1 by cytoplasmic acidification and mitogens | Q40098154 | ||
| Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs | Q43681986 | ||
| Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate | Q46302698 | ||
| Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier. | Q46465251 | ||
| DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1 | Q46784718 | ||
| Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II. | Q46862539 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P921 | main subject | bladder cancer | Q504775 |
| P304 | page(s) | 135 | |
| P577 | publication date | 2015-07-22 | |
| P1433 | published in | Molecular Cancer | Q15724585 |
| P1476 | title | 3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants | |
| P478 | volume | 14 |
| Q55332287 | Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations. |
| Q55279249 | B cell lymphoma with different metabolic characteristics show distinct sensitivities to metabolic inhibitors. |
| Q92740760 | Competitive glucose metabolism as a target to boost bladder cancer immunotherapy |
| Q92758035 | Dihydroartemisinin suppresses bladder cancer cell invasion and migration by regulating KDM3A and p21 |
| Q64226343 | Efficacy of Dual Inhibition of Glycolysis and Glutaminolysis for Therapy of Renal Lesions in Tsc2 Mice |
| Q36198159 | Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine |
| Q90270237 | Malignancy Grade-Dependent Mapping of Metabolic Landscapes in Human Urothelial Bladder Cancer: Identification of Novel, Diagnostic, and Druggable Biomarkers |
| Q50126710 | Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy |
| Q55504431 | Mutations of p53 decrease sensitivity to the anthracycline treatments in bladder cancer cells. |
| Q47274927 | PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies |
| Q99630350 | Up-regulation of DRAM2 promotes tolerance of bladder transitional cell carcinoma to gemcitabine |
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