Uncomplicating the Macrovascular Complications of Diabetes: The 2014 Edwin Bierman Award Lecture

scientific article published in August 2015

Uncomplicating the Macrovascular Complications of Diabetes: The 2014 Edwin Bierman Award Lecture is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2337/DB14-1963
P932PMC publication ID4512224
P698PubMed publication ID26207031

P50authorKarin E. BornfeldtQ87887672
P2860cites workChronic Inflammatory Disorders and Risk of Type 2 Diabetes Mellitus, Coronary Heart Disease, and StrokeQ57388112
Lack of the Antioxidant Enzyme Glutathione Peroxidase-1 Accelerates Atherosclerosis in Diabetic Apolipoprotein E–Deficient MiceQ59284858
Role of bone-marrow- and non-bone-marrow-derived receptor for advanced glycation end-products (RAGE) in a mouse model of diabetes-associated atherosclerosisQ61514318
Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetesQ62583515
COMBINED CLINICAL AND PATHOLOGIC STUDY OF DIABETIC AND NONDIABETIC PERIPHERAL ARTERIAL DISEASEQ76961606
Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohortsQ83393056
Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)Q85063666
Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and humanQ21562369
Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 DiabetesQ22250887
The response-to-retention hypothesis of early atherogenesisQ24629974
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responsesQ24631052
Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosisQ24634165
Atherosclerosis — An Inflammatory DiseaseQ26776972
Insulin resistance, hyperglycemia, and atherosclerosisQ27011696
S100A8 and S100A9 in cardiovascular biology and diseaseQ27024450
Triglycerides and cardiovascular disease: a scientific statement from the American Heart AssociationQ28235865
Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular eventsQ28238975
Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetesQ28299458
Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemiaQ28565000
Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulinQ28574224
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) GroupQ29547282
Loss-of-function mutations in APOC3, triglycerides, and coronary diseaseQ30408720
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosisQ30412997
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activationQ30431948
High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.Q33565025
Testing the role of myeloid cell glucose flux in inflammation and atherosclerosisQ33612986
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.Q33652731
Adipose tissue macrophages promote myelopoiesis and monocytosis in obesityQ33724394
The p75 neurotrophin receptor is required for the major loss of sympathetic nerves from islets under autoimmune attackQ33789390
Mouse Models for Type 1 DiabetesQ33794336
Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesisQ34021724
Type 1 diabetes mellitus and cardiovascular disease: a scientific statement from the American Heart Association and American Diabetes AssociationQ34219439
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophagesQ34316035
miR33 inhibition overcomes deleterious effects of diabetes mellitus on atherosclerosis plaque regression in mice.Q34324735
High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharideQ34334697
Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin.Q34336208
Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient miceQ34399952
Loss-of-function mutations in APOC3 and risk of ischemic vascular diseaseQ34425444
Effect of intensive diabetes treatment on albuminuria in type 1 diabetes: long-term follow-up of the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications studyQ34433105
Risk of cardiovascular disease and total mortality in adults with type 1 diabetes: Scottish registry linkage studyQ34440576
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null miceQ34485920
Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetesQ34693197
Lipolysis, and not hepatic lipogenesis, is the primary modulator of triglyceride levels in streptozotocin-induced diabetic mice.Q34734402
Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophyQ34742779
The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages.Q34801576
Diabetes adversely affects macrophages during atherosclerotic plaque regression in miceQ35043471
Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosisQ35114963
Triglycerides and heart disease: still a hypothesis?Q35120360
Fractalkine is a novel human adipochemokine associated with type 2 diabetesQ35796996
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.Q35849515
Morphological characteristics of coronary atherosclerosis in diabetes mellitusQ36405152
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.Q36603504
Type 1 diabetes and coronary artery diseaseQ36634829
Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophagesQ36742281
Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetesQ36842628
The macrophage at the crossroads of insulin resistance and atherosclerosisQ36843648
Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice.Q36883079
All-cause and cardiovascular mortality in middle-aged people with type 2 diabetes compared with people without diabetes in a large U.K. primary care databaseQ37022658
Closing the loop on inflammation and atherothrombosis: why perform the CIRT and CANTOS trials?Q37026106
The expression of inflammatory genes is upregulated in peripheral blood of patients with type 1 diabetesQ37106490
Proteoglycan mediated lipoprotein retention: a mechanism of diabetic atherosclerosisQ37201521
Increased atherosclerosis in streptozotocin-induced diabetic miceQ37353969
PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null miceQ37397476
Association between plasma monocyte chemoattractant protein-1 concentration and cardiovascular disease mortality in middle-aged diabetic and nondiabetic individualsQ37400830
Update on cardiovascular outcomes at 30 years of the diabetes control and complications trial/epidemiology of diabetes interventions and complications studyQ37403220
Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cellsQ37405753
The receptor for advanced glycation endproducts (RAGE) and cardiovascular diseaseQ37412673
Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid compositionQ37459831
Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosisQ37466366
Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesionsQ37486465
Toll-like receptor agonists promote prolonged triglyceride storage in macrophages.Q37536615
Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.Q37635856
2013 Russell Ross memorial lecture in vascular biology: cellular and molecular mechanisms of diabetes mellitus-accelerated atherosclerosisQ37666671
Cooperation between brain and islet in glucose homeostasis and diabetesQ37698362
Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosisQ37711215
Inflammation and diabetes-accelerated atherosclerosis: myeloid cell mediators.Q38059912
Metabolism of inflammation limited by AMPK and pseudo-starvationQ38074586
Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetesQ38218644
Macrophages, immunity, and metabolic diseaseQ38230879
The cardiovascular effects of metformin: lost in translation?Q38254257
Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trialQ38441000
Immunometabolism: an emerging frontierQ38876919
Suppressor of cytokine signaling 1-derived peptide inhibits Janus kinase/signal transducers and activators of transcription pathway and improves inflammation and atherosclerosis in diabetic mice.Q38976590
Cooperation of adenosine with macrophage Toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene.Q39564669
Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activatorsQ41082185
Diabetes and cardiovascular disease. The Framingham studyQ41509493
Methotrexate--how does it really work?Q43144564
Impact of interleukin-1β antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: results of secondary endpoints from a randomized, placebo-controlled trialQ43624795
Circulating inflammatory markers and the risk of vascular complications and mortality in people with type 2 diabetes and cardiovascular disease or risk factors: the ADVANCE studyQ44440008
Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitusQ44759159
Effect of streptozotocin-induced hyperglycemia on lipid profiles, formation of advanced glycation endproducts in lesions, and extent of atherosclerosis in LDL receptor-deficient miceQ45120387
Hyperlipidemia in concert with hyperglycemia stimulates the proliferation of macrophages in atherosclerotic lesions: potential role of glucose-oxidized LDL.Q45161321
Plasma levels of CXCL1 (GRO-alpha) and CXCL10 (IP-10) are elevated in type 2 diabetic patients: evidence for the involvement of inflammation and angiogenesis/angiostasis in this disease stateQ45417284
Neither B lymphocytes nor antibodies directed against self antigens of the islets of Langerhans are required for development of virus-induced autoimmune diabetes.Q45739869
Type 1 diabetes is associated with increased cyclooxygenase- and cytokine-mediated inflammationQ46513450
Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemiaQ46537808
Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic miceQ46618830
Dyslipidemia, but not hyperglycemia and insulin resistance, is associated with marked alterations in the HDL lipidome in type 2 diabetic subjects in the DIWA cohort: impact on small HDL particlesQ46805800
Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE-/- mice with or without diabetesQ47441517
Serum and urinary concentrations of calprotectin as markers of insulin resistance and type 2 diabetes.Q51353698
Treatment with insulin sensitizer metformin improves arterial properties, metabolic parameters, and liver function in patients with nonalcoholic fatty liver disease: a randomized, placebo-controlled trial.Q51376929
Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis.Q53648299
Autoimmune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin.Q54198243
Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.Q54610885
NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated AtherosclerosisQ56991358
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)2689-2697
P577publication date2015-08-01
P1433published inDiabetesQ895262
P1476titleUncomplicating the Macrovascular Complications of Diabetes: The 2014 Edwin Bierman Award Lecture
P478volume64

Reverse relations

cites work (P2860)
Q57134943Activated protein C reverses epigenetically sustained p66 expression in plaque-associated macrophages in diabetes
Q37083092Does Elevated Glucose Promote Atherosclerosis? Pros and Cons
Q36562533Plasma Prekallikrein Is Associated With Carotid Intima-Media Thickness in Type 1 Diabetes
Q47881764Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCδ Isoform Activation
Q50205101The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype

Search more.