Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice

scientific article published on 11 January 2016

Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1146326K
P356DOI10.1371/JOURNAL.PONE.0146326
P932PMC publication ID4709087
P698PubMed publication ID26751387
P5875ResearchGate publication ID290157351

P50authorMartin SteinmetzQ79983109
P2093author name stringSebastian Zimmer
Dieter Lütjohann
Georg Nickenig
Catharina Lahrmann
Tobias Asdonk
Enzo Lüsebrink
Alexander O Krogmann
P2860cites workCharacterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities.Q51030792
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Priming with synthetic oligonucleotides attenuates pressure overload-induced inflammation and cardiac hypertrophy in mice.Q54292231
Postconditioning with a CpG containing oligodeoxynucleotide ameliorates myocardial infarction in a murine closed-chest model.Q54306542
Activation of Endothelial Toll-Like Receptor 3 Impairs Endothelial FunctionQ56998027
Blocking Toll-Like Receptors 7 and 9 Reduces Postinterventional Remodeling via Reduced Macrophage Activation, Foam Cell Formation, and MigrationQ63915472
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Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of toll-like receptor 9Q80492358
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Toll-like receptor 9 and interferon-γ receptor signaling suppress the B-cell fate of uncommitted progenitors in miceQ37019912
Toll-like receptors in atherosclerosis: a 'Pandora's box' of advances and controversiesQ38153941
CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264.7).Q38288131
Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administrationQ38345478
HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9.Q39057962
Stimulatory type A CpG-DNA induces a Th2-like response in human endothelial cellsQ39494483
Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammationQ40173384
Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activityQ40524997
Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolutionQ41265554
Bacterial DNA signatures in carotid atherosclerosis represent both commensals and pathogens of skin originQ42275172
The activation of liver X receptors inhibits toll-like receptor-9-induced foam cell formationQ43202380
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathwaysQ44807760
Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shockQ44931090
A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formationQ46346484
The Toll-like receptor 9 ligand CPG-C attenuates acute inflammatory cardiac dysfunctionQ48884290
A Toll-like receptor recognizes bacterial DNAQ24290668
Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2Q24338906
Danger signaling in atherosclerosisQ26852204
Cholesterol, inflammation and innate immunityQ28086912
Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extensionQ28541982
The family of five: TIR-domain-containing adaptors in Toll-like receptor signallingQ29615457
Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptorQ30747560
CpG-B ODNs potently induce low levels of IFN-alphabeta and induce IFN-alphabeta-dependent MHC-I cross-presentation in DCs as effectively as CpG-A and CpG-C ODNsQ33343610
Toll-like receptor 9 mediated responses in cardiac fibroblastsQ34050642
Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cellsQ34083770
CpG motifs in bacterial DNA trigger direct B-cell activationQ34307394
Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrow-derived cells and parenchymal cells.Q34400381
Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.Q35015661
Microbial composition of atherosclerotic plaquesQ35031446
The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signalingQ35345969
The immunobiology of the TLR9 subfamilyQ35810913
The toll-like receptor 9 agonist, CpG-oligodeoxynucleotide 1826, ameliorates cardiac dysfunction after trauma-hemorrhageQ36103464
Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligationQ36370469
CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: involving activation of PI3K/Akt signalingQ36456832
TLR9 in health and diseaseQ36526346
In vivo TLR9 inhibition attenuates CpG-induced myocardial dysfunctionQ36830961
Selective roles for toll-like receptors 2, 4, and 9 in systemic inflammation and immune dysfunction following peripheral tissue injury.Q36896481
The Toll-like receptor 9 ligand, CpG oligodeoxynucleotide, attenuates cardiac dysfunction in polymicrobial sepsis, involving activation of both phosphoinositide 3 kinase/Akt and extracellular-signal-related kinase signalingQ36957263
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
toll-like receptorQ408004
P304page(s)e0146326
P577publication date2016-01-11
P1433published inPLOS OneQ564954
P1476titleProinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice
P478volume11

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