Biological Activities of Natural and Engineered Cyclotides, a Novel Molecular Scaffold for Peptide-Based Therapeutics

scientific article published on November 1, 2010

Biological Activities of Natural and Engineered Cyclotides, a Novel Molecular Scaffold for Peptide-Based Therapeutics is …
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scholarly articleQ13442814

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P356DOI10.2174/1874467211003030153
P953full work available at URLhttps://europepmc.org/articles/pmc3328131?pdf=render
https://europepmc.org/articles/PMC3328131
https://europepmc.org/articles/PMC3328131?pdf=render
http://eurekaselect.com/article/download/94111
P932PMC publication ID3328131
P698PubMed publication ID20858197

P2093author name stringJulio A. Camarero
Angie E. Garcia
P2860cites workDaptomycinQ80608154
Studies on the membrane interactions of the cyclotides kalata B1 and kalata B6 on model membrane systems by surface plasmon resonanceQ81268599
Inhibition of platelet aggregation by grafting RGD and KGD sequences on the structural scaffold of small disulfide-rich proteinsQ83347729
Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinisQ24555208
Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acidQ24604552
"Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptidesQ24634502
Liver transplantation with use of cyclosporin a and prednisoneQ24645567
Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytesQ24656955
Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motifQ27620726
Circular proteins in plants: solution structure of a novel macrocyclic trypsin inhibitor from Momordica cochinchinensisQ27631076
Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanismQ27636769
Twists, knots, and rings in proteins. Structural definition of the cyclotide frameworkQ27640161
Divalent cation coordination and mode of membrane interaction in cyclotides: NMR spatial structure of ternary complex Kalata B7/Mn2+/DPC micelleQ27649924
Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug ScaffoldQ27653739
Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1Q27729926
Oldenlandia affinis (R&S;) DC. A plant containing uteroactive peptides used in African traditional medicineQ28145698
The fluorescent toolbox for assessing protein location and functionQ29615075
Synthesis of proteins by native chemical ligationQ29616750
Intracellular protein interaction mapping with FRET hybridsQ30159548
Fmoc-based synthesis of peptide alpha-thioesters using an aryl hydrazine supportQ30164046
Peptide chemical ligation inside living cells: in vivo generation of a circular protein domain.Q30167926
Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1.Q30580507
Seven novel macrocyclic polypeptides from Viola arvensisQ30654560
Structural requirements for the biosynthesis of backbone cyclic peptide libraries.Q30701399
Production of cyclic peptides and proteins in vivoQ30816360
Retrovirally delivered random cyclic Peptide libraries yield inhibitors of interleukin-4 signaling in human B cellsQ30841661
Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversityQ30862569
Use of inteins for the in vivo production of stable cyclic peptide libraries in E. coli.Q30876200
Cyclotides: a novel type of cytotoxic agentsQ31121086
A biomimetic strategy in the synthesis and fragmentation of cyclic proteinQ32048383
Split-intein mediated circular ligation used in the synthesis of cyclic peptide libraries in E. coli.Q33286530
Development of a cell-based fluorescence resonance energy transfer reporter for Bacillus anthracis lethal factor proteaseQ33288593
Discovery of antibacterial cyclic peptides that inhibit the ClpXP proteaseQ33289276
Biosynthesis of circular proteins in plantsQ33310757
The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicityQ33314505
Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteinsQ33467195
Gramicidin S and polymyxins: the revival of cationic cyclic peptide antibioticsQ33496165
Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I.Q33506664
Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanismsQ33543787
Cyclotides, a promising molecular scaffold for peptide-based therapeuticsQ33610239
Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptorsQ33650270
Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activityQ33796227
A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensinsQ33876954
Protein splicing and its applicationsQ34024340
In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1Q34115228
Conformation and mode of membrane interaction in cyclotides. Spatial structure of kalata B1 bound to a dodecylphosphocholine micelleQ34568826
Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity.Q34747442
An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfidesQ35588664
Sunflower trypsin inhibitor-1.Q35950330
Expressed protein ligation using an N-terminal cysteine containing fragment generated in vivo from a pelB fusion proteinQ35968333
The chemistry and enzymology of the type I signal peptidasesQ36280398
Synthesis of proteins by native chemical ligation using Fmoc-based chemistryQ36321187
The cyclotide family of circular miniproteins: nature's combinatorial peptide template.Q36379014
CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineeringQ36454443
Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxinQ36737682
Circling the enemy: cyclic proteins in plant defenceQ37473960
Discovery, structure and biological activities of cyclotides.Q37496224
Cyclotides as templates in drug designQ37624969
Characterization of a self-splicing mini-intein and its conversion into autocatalytic N- and C-terminal cleavage elements: facile production of protein building blocks for protein ligationQ38325022
N-terminal cysteinyl proteins can be prepared using thrombin cleavageQ38424805
An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligationQ38589907
Cyclic peptides from Oldenlandia affinis DC. Molecular and biological propertiesQ39031062
Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipesQ39598958
Chemical Synthesis of Peptides and ProteinsQ39994032
The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.Q40095221
Key role of glutamic acid for the cytotoxic activity of the cyclotide cycloviolacin O2.Q40334591
Cytotoxic cyclotides from Viola tricolorQ40585258
Post-translational peptide bond formation during concanavalin A processing in vitroQ42020870
Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep.Q42163975
Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design.Q43228777
Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffoldQ43273120
New methods for proteomic research: preparation of proteins with N-terminal cysteines for labeling and conjugationQ43278079
Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interactionQ44447645
Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot.Q44898692
Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?Q45227373
The anthelmintic activity of the cyclotides: natural variants with enhanced activityQ45741061
Biosynthesis of a fully functional cyclotide inside living bacterial cells.Q45999380
Ubiquitin fusion technique and related methodsQ46126283
Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotidesQ46215974
Oxytocic principles of Oldenlandia affinisQ46344642
Isolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide.Q46432915
Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail).Q46537354
Biosynthesis of the cyclotide Kalata B1 by using protein splicingQ46808548
Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.Q46849544
Ultra-stable peptide scaffolds for protein engineering-synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2.Q46866403
Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceaeQ46914746
Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.Q47797295
Expression of atrial natriuretic factor as a cleavable fusion protein with chloramphenicol acetyltransferase in Escherichia coliQ48322692
An asparaginyl endopeptidase mediates in vivo protein backbone cyclization.Q53534512
On the Effect of a Polypeptide Isolated from “Kalata-Kalata” (Oldenlandia affinis DC) on the Oestrogen Dominated UterusQ54026081
Protein expression using cotranslational fusion and cleavage of ubiquitin. Mutagenesis of the glutathione-binding site of human Pi class glutathione S-transferase.Q54625888
θ-Defensins Prevent HIV-1 Env-mediated Fusion by Binding gp41 and Blocking 6-Helix Bundle FormationQ57372497
Circular β-lactamase: stability enhancement by cyclizing the backboneQ57840029
Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-IIQ58231231
The leucine zipper domain controls the orientation of AP-1 in the NFAT.AP-1.DNA complexQ67426632
Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structureQ73761689
Chemical ligation of unprotected peptides directly from a solid supportQ74481443
The in vitro ligation of bacterially expressed proteins using an intein from Methanobacterium thermoautotrophicumQ77953818
Purification of proteins fused to either the amino or carboxy terminus of the Mycobacterium xenopi gyrase A inteinQ78005223
The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1Q80546763
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectprotein engineeringQ169525
P304page(s)153-163
P577publication date2010-11-01
P1433published inCurrent molecular pharmacologyQ26842459
P1476titleBiological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-based therapeutics
Biological Activities of Natural and Engineered Cyclotides, a Novel Molecular Scaffold for Peptide-Based Therapeutics
P478volume3