Clinical Characteristics and Prognostic Significance of TERT Promoter Mutations in Cancer: A Cohort Study and a Meta-Analysis

scientific article published on 22 January 2016

Clinical Characteristics and Prognostic Significance of TERT Promoter Mutations in Cancer: A Cohort Study and a Meta-Analysis is …
instance of (P31):
scholarly articleQ13442814
meta-analysisQ815382

External links are
P819ADS bibcode2016PLoSO..1146803Y
P356DOI10.1371/JOURNAL.PONE.0146803
P8608Fatcat IDrelease_tghnfyvbzzgbtmfxuiuptcwk6m
P932PMC publication ID4723146
P698PubMed publication ID26799744
P5875ResearchGate publication ID291517554

P2093author name stringJian Hu
Ping Yuan
Wang Lv
Xiao-Shuai Yuan
Abudumailamu Abuduwufuer
Lu-Ming Wang
Jin-lin Cao
P2860cites workBRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrenceQ27853042
TERT promoter mutation status as an independent prognostic factor in cutaneous melanomaQ27853068
Mutations of the BRAF gene in human cancerQ27860760
Meta-analysis in clinical trialsQ27860779
Statistical aspects of the analysis of data from retrospective studies of diseaseQ27860916
Telomerase regulation at the crossroads of cell fateQ28308086
TERT promoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA.Q54347306
Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.Q54374929
Melanomas of unknown primary frequently harbor TERT-promoter mutationsQ87164455
Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q lossQ39139952
TERT promoter mutations contribute to subset prognostication of lower-grade gliomasQ39150267
TERT promoter mutation in resectable hepatocellular carcinomas: a strong association with hepatitis C infection and absence of hepatitis B infectionQ42216457
TERT promoter mutations in skin cancer: the effects of sun exposure and X-irradiation.Q42456732
TERT promoter mutations predict worse survival in laryngeal cancer patientsQ43740263
TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomasQ43801346
Telomerase reverse transcriptase gene promoter mutations help discern the origin of urogenital tumors: a genomic and molecular studyQ43848797
Molecular alterations in endometrial and ovarian clear cell carcinomas: clinical impacts of telomerase reverse transcriptase promoter mutation.Q45143637
Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma.Q47704838
High incidence of activating TERT promoter mutations in meningiomas undergoing malignant progressionQ48857394
Telomerase in differentiated thyroid cancer: promoter mutations, expression and localization.Q52998892
Recurrent TERT promoter mutations in non-small cell lung cancers.Q54182438
TERT promoter mutations are associated with distant metastases in papillary thyroid carcinoma.Q54297209
TERT promoter mutations in clear cell renal cell carcinoma.Q54314475
TERT promoter mutations: a novel independent prognostic factor in primary glioblastomasQ28397245
Highly recurrent TERT promoter mutations in human melanomaQ29614798
TERT promoter mutations in familial and sporadic melanomaQ29614920
Telomeres and human disease: ageing, cancer and beyondQ29615353
Regulation of telomerase by telomeric proteinsQ29616133
TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancerQ33682388
TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomasQ33688439
Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomasQ33688915
The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumorsQ33709979
Melanoma genetics and the development of rational therapeuticsQ33726956
TERT promoter mutations lead to high transcriptional activity under hypoxia and temozolomide treatment and predict poor prognosis in gliomasQ33769095
Expression level of hTERT is regulated by somatic mutation and common single nucleotide polymorphism at promoter region in glioblastomaQ33917659
Alternative lengthening of telomeres: models, mechanisms and implicationsQ34107386
Prognostic value analysis of mutational and clinicopathological factors in non-small cell lung cancerQ34150095
TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomasQ34313648
High frequency of TERT promoter mutation in small cell carcinoma of bladder, but not in small cell carcinoma of other originsQ34469034
TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlationsQ34499685
Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off againQ34527718
TERT promoter mutations and gene amplification: promoting TERT expression in Merkel cell carcinomaQ34654382
Oncogenic Braf induces melanocyte senescence and melanoma in miceQ34974162
Telomerase as a promising target for human cancer gene therapy.Q35126106
Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosisQ36107360
Human melanocyte biology, toxicology, and pathologyQ36314397
Telomere and telomerase in stem cellsQ36758330
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewalQ36762656
Role of telomeres and telomerase in genomic instability, senescence and cancerQ36927502
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesionsQ37064910
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.Q37149600
TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphismQ37256055
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastomaQ37316068
Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy.Q37624069
TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urineQ37663771
Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paragangliaQ38982558
The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomasQ39076273
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcomeQ39098321
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)e0146803
P577publication date2016-01-22
P1433published inPLOS OneQ564954
P1476titleClinical Characteristics and Prognostic Significance of TERT Promoter Mutations in Cancer: A Cohort Study and a Meta-Analysis
P478volume11

Reverse relations

cites work (P2860)
Q92786863Alternative lengthening of telomeres is the major telomere maintenance mechanism in astrocytoma with isocitrate dehydrogenase 1 mutation
Q47916891Characterization and Impact of TERT Promoter Region Mutations on Clinical Outcome in Renal Cell Carcinoma.
Q100526089Droplet-digital PCR reveals frequent mutations in TERT promoter region in breast fibroadenomas and phyllodes tumours, irrespective of the presence of MED12 mutations
Q52727349Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer.
Q92749153Risk Factors for Early Mortality Among Patients with Glioma: A Population-Based Study
Q41896400Severe nivolumab-induced pneumonitis preceding durable clinical remission in a patient with refractory, metastatic lung squamous cell cancer: a case report
Q64935865TERT Promoter Mutations are Associated with Visceral Spreading in Melanoma of the Trunk.
Q55443450Telomere Maintenance Mechanisms in Cancer.
Q49194424The prognostic value of NRF2 in solid tumor patients: a meta-analysis
Q49436326The prognostic value of p62 in solid tumor patients: a meta-analysis
Q51764891Trade-offs in aging lung diseases: a review on shared but opposite genetic risk variants in idiopathic pulmonary fibrosis, lung cancer and chronic obstructive pulmonary disease.

Search more.