Regulation of nuclear TDP-43 by NR2A-containing NMDA receptors and PTEN.

scientific article published in March 2012

Regulation of nuclear TDP-43 by NR2A-containing NMDA receptors and PTEN. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/JCS.095729
P932PMC publication ID3336381
P698PubMed publication ID22526419

P50authorHonglin TianQ64355160
P2093author name stringTianyuan Cui
Qi Wan
Mei Zheng
Dong-Sheng Fan
Mingxia Liao
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
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Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.Q29568322
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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathwaysQ29619779
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6Q30492839
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degenerationQ30493749
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesisQ30494776
Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily membersQ31836858
Chronic mitochondrial inhibition induces glutamate-mediated corticomotoneuron death in an organotypic culture modelQ31848460
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosisQ33649745
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The changing landscape of ischaemic brain injury mechanisms.Q33678157
Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).Q33799562
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Bisperoxovanadium compounds are potent PTEN inhibitors.Q34321332
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TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusionsQ35928153
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosisQ36734898
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formationQ36741538
Phosphatase PTEN in neuronal injury and brain disordersQ36980931
Glutamate receptor plasticity and activity-regulated cytoskeletal associated protein regulation in the phrenic motor nucleus may mediate spontaneous recovery of the hemidiaphragm following chronic cervical spinal cord injuryQ36990537
The nuclear affairs of PTEN.Q37063858
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Structural determinants of the cellular localization and shuttling of TDP-43.Q39924105
Preclinical testing of neuroprotective neurotrophic factors in a model of chronic motor neuron degenerationQ40922137
Recruitment of functional GABA(A) receptors to postsynaptic domains by insulinQ41094368
Neuroprotective effect of erythropoietin in amyotrophic lateral sclerosis (ALS) model in vitro. Ultrastructural studyQ43103365
In vitro neurotoxic properties and excitatory aminoacids concentration in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Relationship with the degree of certainty of disease diagnosesQ43266988
Regulation of PINK1 by NR2B-containing NMDA receptors in ischemic neuronal injuryQ43271378
Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.Q45919147
Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic toleranceQ46440028
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Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase.Q46817719
Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition.Q46852738
Differential vulnerability of autonomic and somatic motor neurons to N-methyl-D-aspartate-induced excitotoxicityQ47616716
Relative neuroprotective effects of dizocilpine and isoflurane during focal cerebral ischemia in the rat.Q47856562
Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neuronsQ48137669
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Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.Q48183466
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.Q48199429
NMDA-dependent superoxide production and neurotoxicityQ48234286
NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivoQ48241774
Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites.Q48535231
Modulation of GABAA receptor function by tyrosine phosphorylation of beta subunitsQ48679503
Abnormal glutamate metabolism in amyotrophic lateral sclerosis.Q51628220
TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.Q51920306
Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.Q53299106
Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortexQ57752898
A clinical trial of dextromethorphan in amyotrophic lateral sclerosisQ73598803
Astroglial alterations in amyotrophic lateral sclerosis (ALS) model of slow glutamate excitotoxicity in vitroQ79236027
P4510describes a project that usesImageJQ1659584
P433issuePt 6
P407language of work or nameEnglishQ1860
P304page(s)1556-1567
P577publication date2012-03-01
P1433published inJournal of Cell ScienceQ1524177
P1476titleRegulation of nuclear TDP-43 by NR2A-containing NMDA receptors and PTEN.
P478volume125

Reverse relations

cites work (P2860)
Q35194634A network of RNA and protein interactions in Fronto Temporal Dementia
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Q46082313Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries
Q36529884Differential roles of GluN2A- and GluN2B-containing NMDA receptors in neuronal survival and death.
Q55437977ERK 1/2 Activation Mediates the Neuroprotective Effect of BpV(pic) in Focal Cerebral Ischemia-Reperfusion Injury.
Q38100646GluN2A versus GluN2B: twins, but quite different
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Q35274780Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia
Q90707597MicroRNA-26b/PTEN Signaling Pathway Mediates Glycine-Induced Neuroprotection in SAH Injury
Q92187641PTEN Inhibition Protects Against Experimental Intracerebral Hemorrhage-Induced Brain Injury Through PTEN/E2F1/β-Catenin Pathway
Q38690404Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis
Q64084703Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors
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Q92236554The neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage

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