The role of phosphoinositide 3-kinase signaling in intestinal inflammation

scientific article published on 9 April 2012

The role of phosphoinositide 3-kinase signaling in intestinal inflammation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2012/358476
P932PMC publication ID3337621
P698PubMed publication ID22570785
P5875ResearchGate publication ID224926677

P2093author name stringCatherine M Cahill
Jack T Rogers
W Allan Walker
P2860cites workMal connects TLR2 to PI3Kinase activation and phagocyte polarizationQ24310427
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Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.Q51981008
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The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice.Q54684259
Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer.Q54704655
Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cellsQ56901814
Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor IQ57013778
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Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammationQ73867640
Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2FQ73925270
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[Expression of phosphatidylinositol 3-kinase and effects of wortmannin on the expression of tumor necrosis factor-alpha in ulcerative colitis]Q80209923
Up-regulation of the phosphoinositide 3-kinase pathway in human lamina propria T lymphocytesQ80593225
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The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cellsQ40726959
Phosphatidylinositol 3-kinase-dependent pathways oppose Fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells. Implications for inflammatory diarrheal statesQ40781206
IRAK-2 and PI 3-kinase synergistically activate NF-kappaB and AP-1.Q40874666
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Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophagesQ41461581
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Tumor suppressor FOXO3 participates in the regulation of intestinal inflammationQ41830299
Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1.Q42010475
Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.Q42431545
Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infectionQ42566826
Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cellsQ42726346
Wound healing of intestinal epithelial cellsQ42732189
T cells of the human intestinal lamina propria are high producers of interleukin-10.Q42747570
Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cellsQ42755379
Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activityQ42826349
Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitisQ43162041
Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinaseQ43166807
Interleukin-1 receptor signaling protects mice from lethal intestinal damage caused by the attaching and effacing pathogen Citrobacter rodentium.Q43192584
Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in miceQ43261400
Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligandQ44794576
Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation.Q46311421
Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivoQ46985163
Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activationQ28253820
PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategiesQ28263112
Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophagesQ28505138
Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthmaQ28584858
Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathwaysQ28588530
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouseQ28589701
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signalingQ28593045
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismQ29547302
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasisQ29547656
TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src.Q30159856
Toll-like receptor signaling in cell proliferation and survivalQ33598805
The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation.Q33734148
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The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activationQ34308699
Phosphoinositide 3-kinases in the gut: a link between inflammation and cancer?Q34399413
Basic and translational understandings of microbial recognition by toll-like receptors in the intestineQ34588751
p53 negatively regulates intestinal immunity by delaying mucosal T cell cyclingQ34791990
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.Q35129307
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Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways.Q37671627
Inhibitors of phosphatidylinositol-3-kinase in cancer therapyQ37696628
Intestinal dendritic cells: their role in bacterial recognition, lymphocyte homing, and intestinal inflammationQ37707264
PI-3-Kinase inhibitors in colorectal cancer.Q37821024
Caco-2 cells express type I interleukin-1 receptors: ligand binding enhances proliferationQ38301983
Glycogen synthase kinase 3-β: A master regulator of toll-like receptor-mediated chronic intestinal inflammationQ38340778
A preferential p110alpha/gamma PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-kappaB-dependent manner.Q39749749
Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cellsQ39792472
The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasionQ39932134
Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells.Q40016473
A phosphorylation site in the Toll-like receptor 5 TIR domain is required for inflammatory signalling in response to flagellinQ40198699
TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expressionQ40284387
Class I and III phosphatidylinositol 3'-kinase play distinct roles in TLR signaling pathwayQ40284432
Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cellsQ40286504
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.Q40316731
A phosphatidyl-inositol-3-kinase-dependent anti-inflammatory pathway activated by Salmonella in epithelial cells.Q40466482
IL-1beta-induced phosphorylation of PKB/Akt depends on the presence of IRAK-1.Q40679156
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)358476
P577publication date2012-04-09
P1433published inJournal of Signal TransductionQ26841830
P1476titleThe role of phosphoinositide 3-kinase signaling in intestinal inflammation
P478volume2012

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cites work (P2860)
Q35108521A systems biological approach reveals multiple crosstalk mechanism between gram-positive and negative bacterial infections: an insight into core mechanism and unique molecular signatures
Q36253681Could a swimming creature inform us on intestinal diseases? Lessons from zebrafish
Q92826281For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors
Q64966153Identification and analysis of key genes associated with ulcerative colitis based on DNA microarray data.
Q54351824Modulation of gastric mucosal inflammatory responses to Helicobacter pylori via ghrelin-induced protein kinase Cδ tyrosine phosphorylation.
Q90224037Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation
Q85969244Role of ghrelin-induced phosphatidylinositol 3-kinase activation in modulation of gastric mucosal inflammatory responses to Helicobacter pylori

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