Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2

scientific article published in August 2015

Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.4615-14.2015
P932PMC publication ID4524980
P698PubMed publication ID26245973

P50authorChristos GkogkasQ42684302
Jean-Claude LacailleQ58670633
Arkady KhoutorskyQ93249738
P2093author name stringNahum Sonenberg
Karim Nader
Argel Aguilar-Valles
Edna Matta-Camacho
P2860cites workCorrection of fragile X syndrome in mice.Q22251255
The Autistic Neuron: Troubled Translation?Q22252314
Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmissionQ24304928
Altered synaptic plasticity in a mouse model of fragile X mental retardationQ24530695
Metabotropic glutamate receptors trigger postsynaptic protein synthesisQ24561912
A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.Q24654933
Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activationQ24657890
Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutationsQ24673663
Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autismQ27329063
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translationQ27860920
Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depressionQ28257629
The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampusQ28509500
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTDQ28585633
Autism-related deficits via dysregulated eIF4E-dependent translational controlQ28592812
The mGluR theory of fragile X mental retardationQ29615060
Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP.Q33685348
The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brainQ33838422
mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autismQ34053492
Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.Q34157712
AFQ056, a new mGluR5 antagonist for treatment of fragile X syndromeQ34164189
Fragile X syndrome: an update on developing treatment modalitiesQ34292108
Exaggerated translation causes synaptic and behavioural aberrations associated with autismQ34319260
Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndromeQ34400166
The S6 kinase signaling pathway in the control of development and growth.Q34988715
Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyondQ35614072
Reactivation of stalled polyribosomes in synaptic plasticityQ37218559
Autism spectrum disorders in tuberous sclerosis: pathogenetic pathways and implications for treatmentQ37703975
Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome.Q38285569
The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction.Q39757736
Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndromeQ41849184
Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletionQ42059359
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.Q42511063
mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient miceQ42525384
Differential distribution of group I metabotropic glutamate receptors during rat cortical developmentQ43988651
Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.Q44978632
Persistent transcription- and translation-dependent long-term potentiation induced by mGluR1 in hippocampal interneurons.Q46031520
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.Q46626541
Prolonged epileptiform discharges induced by altered group I metabotropic glutamate receptor-mediated synaptic responses in hippocampal slices of a fragile X mouse model.Q46681406
Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depressionQ46900047
Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndromeQ46923253
Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation.Q46932828
Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression.Q46958338
Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term DepressionQ60141744
P4510describes a project that usesImageJQ1659584
P433issue31
P407language of work or nameEnglishQ1860
P921main subjectautismQ38404
P304page(s)11125-11132
P577publication date2015-08-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleInhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2
P478volume35

Reverse relations

cites work (P2860)
Q50301356Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling.
Q90243427Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling
Q90244808Comparative psychopharmacology of autism and psychotic-affective disorders suggests new targets for treatment
Q38678066Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder
Q92237673Group I mGluR-Mediated Activation of Martinotti Cells Inhibits Local Cortical Circuitry in Human Cortex
Q41634132Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice
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Q36674162Label-Free Proteomic Analysis of Protein Changes in the Striatum during Chronic Ethanol Use and Early Withdrawal
Q47601432Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity
Q46936292Melanin concentrating hormone modulates oxytocin-mediated marble burying
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Q58614653Prosocial effects of an oxytocin metabolite, but not synthetic oxytocin receptor agonists, in a mouse model of autism
Q40562510Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex
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Q33562835β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X.

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