The Role of Metabotropic Glutamate Receptors in Social Behavior in Rodents

journal article from 'International Journal of Molecular Sciences' published in 2019

The Role of Metabotropic Glutamate Receptors in Social Behavior in Rodents is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS20061412
P953full work available at URLhttps://www.mdpi.com/1422-0067/20/6/1412
P932PMC publication ID6470515
P698PubMed publication ID30897826

P50authorJohannes KornhuberQ17068400
Iulia ZoicasQ64605006
P2093author name stringJohannes Kornhuber
Iulia Zoicas
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JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male miceQ46681958
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mGlu₅-GABAB interplay in animal models of positive, negative and cognitive symptoms of schizophreniaQ48235210
JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1.Q48281536
Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidineQ48374986
Antiaggressive effects of MPEP, a selective antagonist of mGlu5 receptors, in agonistic interactions between male mice.Q48402443
Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatmentQ48412670
Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing ratQ48449710
Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: a light and electron microscopic studyQ48487757
Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampusQ48518514
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Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodentsQ48695747
Male rat sexual behaviorQ48709630
Social discrimination procedure: an alternative method to investigate juvenile recognition abilities in ratsQ48800299
Mate preference and avoidance in female rats following treatment with scopolamineQ48802456
mGluR5 activation in the nucleus accumbens is not essential for sexual behavior or cross-sensitization of amphetamine responses by sexual experience.Q48857672
A new test for social investigation in mice: effects of d-amphetamineQ49108010
Stimulation of metabotropic glutamate (mGlu) 2 receptor and blockade of mGlu1 receptor improve social memory impairment elicited by MK-801 in rats.Q50747816
LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats.Q51081613
Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats.Q51972251
Social amnesia in mice lacking the oxytocin gene.Q52025978
Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.Q52056265
Effects of (RS)-3,4-DCPG, a mixed AMPA antagonist/mGluR8 agonist, on aggressive behavior in mice.Q53861972
Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism.Q55404711
The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementiasQ56481539
Emotion regulation in social anxiety and depression: a systematic review of expressive suppression and cognitive reappraisalQ57128839
Comorbid social anxiety disorder in patients with alcohol use disorder: A systematic reviewQ57157301
Negative Allosteric Modulators of mGlu Receptor as Putative Antipsychotic DrugsQ57191778
Sex-dependent effects of in utero cannabinoid exposure on cortical functionQ58749791
Social Skills Deficits in Autism Spectrum Disorder: Potential Biological Origins and Progress in Developing Therapeutic AgentsQ58780865
Fragile X-Associated Neuropsychiatric Disorders (FXAND)Q59335598
Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brainQ71960374
The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in ratsQ79775681
Mutual activation of glutamatergic mGlu4 and muscarinic M4 receptors reverses schizophrenia-related changes in rodentsQ90582173
Social brain, social dysfunction and social withdrawalQ91655362
mGluR5 upregulation and the effects of repeated methamphetamine administration and withdrawal on the rewarding efficacy of ketamine and social interactionQ91867422
Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2-/- MiceQ93356231
Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autismQ27329063
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptorQ27627995
Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteinsQ28141190
mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase CQ28191049
Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampusQ28248856
Metabotropic glutamate receptors in the basal ganglia motor circuitQ28280931
Metabotropic glutamate receptors as novel targets for anxiety and stress disordersQ28303826
Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sitesQ28513710
Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNSQ28569174
Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapseQ28574390
Co-stimulation of mGluR5 and N-Methyl-D-aspartate Receptors Is Required for Potentiation of Excitatory Synaptic Transmission in Hippocampal NeuronsQ28577999
Autism-related deficits via dysregulated eIF4E-dependent translational controlQ28592812
Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspringQ28941206
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stressQ29618764
Opposing roles of mGluR8 in measures of anxiety involving non-social and social challengesQ30465038
The neuropeptide oxytocin facilitates pro-social behavior and prevents social avoidance in rats and miceQ30504502
Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficitsQ30578270
Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP.Q33685348
Neurogenetics of aggressive behavior: studies in rodentsQ33882380
Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.Q33923583
Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression.Q34272354
MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity.Q34299925
ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterizationQ34318862
Exaggerated translation causes synaptic and behavioural aberrations associated with autismQ34319260
Automated apparatus for quantitation of social approach behaviors in mice.Q34345417
Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in ratsQ34355480
Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeuticsQ34429155
Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depressionQ34461947
G protein-coupled receptor allosterism and complexingQ34523552
In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.Q34645676
Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving miceQ34715081
Mood disorders: regulation by metabotropic glutamate receptorsQ34731407
The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studiesQ34798345
Estrogen receptors stimulate brain region specific metabotropic glutamate receptors to rapidly initiate signal transduction pathwaysQ35137643
Divalent cations modulate the activity of metabotropic glutamate receptorsQ40595668
Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons.Q40720745
Striatal N-acetylaspartate synthetase Shati/Nat8l regulates depression-like behaviors via mGluR3-mediated serotonergic suppression in miceQ41918980
Differential regulation of CaMKIIα interactions with mGluR5 and NMDA receptors by Ca(2+) in neurons.Q41975252
Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletionQ42059359
Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptorQ42475147
Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.Q42495060
Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinaseQ43068986
Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulatorQ43108248
Neonatal phencyclidine treatment in mice induces behavioral, histological and neurochemical abnormalities in adulthoodQ43282817
[3H]LY341495 binding to group II metabotropic glutamate receptors in rat brainQ43675497
Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptorsQ43715218
Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in ratsQ44063873
Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathwaysQ44068680
Olfactory recognition of conspecifics by domestic Norway ratsQ44159776
Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes.Q44213478
MPEP, a selective metabotropic glutamate receptor 5 antagonist, attenuates conditioned taste aversion in ratsQ44437768
Effects of the dopamine reuptake inhibitor PTT on reinstatement and on food- and cocaine-maintained responding in rhesus monkeysQ44736250
A chemical LTP induced by co-activation of metabotropic and N-methyl-D-aspartate glutamate receptors in hippocampal CA1 neurons.Q44744787
Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine ReleaseQ44793030
The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in ratsQ44801606
Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: possible implications for the pharmacotherapy of autism spectrum disordersQ44968387
Functional interaction between mGlu 5 and NMDA receptors in a rat model of Parkinson's diseaseQ45279113
Behavioural profile of selective ligands for mGlu7 and mGlu8 glutamate receptors in agonistic encounters between mice.Q45923871
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptorsQ35143358
Structure of the metabotropic glutamate receptorQ35172787
Can social interaction be used to measure anxiety?Q35177016
Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.Q35760210
The role of metabotropic glutamate receptors in Alzheimer's disease.Q35801144
Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophreniaQ35810054
Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2Q35916445
Sexual behavior in male rodentsQ35951264
The group II metabotropic glutamate receptor agonist LY379268 reduces toluene-induced enhancement of brain-stimulation reward and behavioral disturbances.Q35952221
Estrogen Receptor β Activation Rapidly Modulates Male Sexual Motivation through the Transactivation of Metabotropic Glutamate Receptor 1a.Q36084405
Metabotropic Glutamate Receptor Subtype 7 in the Bed Nucleus of the Stria Terminalis is Essential for Intermale AggressionQ36449664
Effects of metabotropic glutamate receptor ligands on male sexual behavior in ratsQ36472772
Metabotropic glutamate receptors as a strategic target for the treatment of epilepsyQ36513465
Glutamate receptors and painQ36655431
The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizationsQ36805310
Metabotropic glutamate receptors: phosphorylation and receptor signalingQ36896581
Role of social encounter-induced activation of prefrontal serotonergic systems in the abnormal behaviors of isolation-reared mice.Q36927765
NMDA receptor antagonism: escalation of aggressive behavior in alcohol-drinking miceQ36959436
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The Emerging Role of Metabotropic Glutamate Receptors in the Pathophysiology of Chronic Stress-Related DisordersQ37172873
Involvement of GABAB Receptor Signaling in Antipsychotic-like Action of the Novel Orthosteric Agonist of the mGlu4 Receptor, LSP4-2022.Q37172877
Glutamate, glutamate receptors, and downstream signaling pathwaysQ37249255
Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophreniaQ37341995
Metabotropic glutamate receptors: physiology, pharmacology, and diseaseQ37670222
Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulatorQ37689367
mGluR antagonists and GABA agonists as novel pharmacological agents for the treatment of autism spectrum disordersQ38046662
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Animal models of social avoidance and social fearQ38113995
Group III metabotropic glutamate receptors: pharmacology, physiology and therapeutic potentialQ38242117
Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome.Q38285569
Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents.Q40362021
Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.Q40458602
Dopamine and sexual behaviorQ40538689
Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cellsQ40542828
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1412
P577publication date2019-01-01
2019-03-20
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleThe Role of Metabotropic Glutamate Receptors in Social Behavior in Rodents
P478volume20

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