Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors

scientific article published on 6 August 2015

Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP12830
P932PMC publication ID4526890
P698PubMed publication ID26245983
P5875ResearchGate publication ID280871029

P50authorDonald R RonningQ56929923
Steven J SucheckQ56929936
P2093author name stringSri Kumar Veleti
Brittney N Wilson
Jared J Lindenberger
P2860cites workTotally drug-resistant tuberculosis in India.Q55055446
Five-membered ring azasugars as potent inhibitors of alpha-L-rhamnosidase (naringinase) from Penicillium decumbensQ72254494
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Structure of Streptomyces Maltosyltransferase GlgE, a Homologue of a Genetically Validated Anti-tuberculosis TargetQ27673803
Structural Insight into How Streptomyces coelicolor Maltosyl Transferase GlgE Binds α-Maltose 1-Phosphate and Forms a Maltosyl-enzyme IntermediateQ27682734
Structural basis for sugar translocation through maltoporin channels at 3.1 A resolutionQ27730332
Towards automated crystallographic structure refinement with phenix.refineQ27860678
Phasercrystallographic softwareQ27860930
Features and development of CootQ27861079
Optimized Hydrophobic Interactions and Hydrogen Bonding at the Target-Ligand Interface Leads the Pathways of Drug-DesigningQ28475117
Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathwayQ28486696
Reaching for high-hanging fruit in drug discovery at protein-protein interfacesQ29547258
Deciphering key features in protein structures with the new ENDscript serverQ29617219
electronic Ligand Builder and Optimization Workbench (eLBOW): a tool for ligand coordinate and restraint generationQ29617258
Nomenclature for sugar-binding subsites in glycosyl hydrolasesQ29618485
Synthesis of a C-phosphonate mimic of maltose-1-phosphate and inhibition studies on Mycobacterium tuberculosis GlgE.Q33622421
Does directly observed therapy (DOT) reduce drug resistant tuberculosis?Q33788435
Synthesis of a poly-hydroxypyrolidine-based inhibitor of Mycobacterium tuberculosis GlgEQ34361158
Stacking interactions between carbohydrate and protein quantified by combination of theoretical and experimental methodsQ34441077
Recent developments of transition-state analogue glycosidase inhibitors of non-natural product originQ34527463
An oxocarbenium-ion intermediate of a ribozyme reaction indicated by kinetic isotope effectsQ34787673
Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infectionQ35006626
Synthesis of 2-deoxy-2,2-difluoro-α-maltosyl fluoride and its X-ray structure in complex with Streptomyces coelicolor GlgEI-V279S.Q35811933
Hydrophobicity--shake flasks, protein folding and drug discoveryQ37636267
Glycosidase inhibition: assessing mimicry of the transition stateQ37672358
Unexpected and widespread connections between bacterial glycogen and trehalose metabolismQ37862890
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Bacterial toxin inhibitors based on multivalent scaffoldsQ38069445
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectMycobacterium tuberculosisQ130971
crystal structureQ895901
P304page(s)12830
P577publication date2015-08-06
P1433published inScientific ReportsQ2261792
P1476titleCrystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors
P478volume5

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cites work (P2860)
Q38971223Current perspectives on the families of glycoside hydrolases of Mycobacterium tuberculosis: their importance and prospects for assigning function to unknowns
Q55437850Decaprenyl-phosphoryl-ribose 2'-epimerase (DprE1): challenging target for antitubercular drug discovery.
Q38291242Ligand-bound Structures and Site-directed Mutagenesis Identify the Acceptor and Secondary Binding Sites of Streptomyces coelicolor Maltosyltransferase GlgE.
Q36330392Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism
Q36629840Targeting the trehalose utilization pathways of Mycobacterium tuberculosis
Q50203520Zwitterionic pyrrolidene-phosphonates: inhibitors of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S.

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