A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation.

scientific article

A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/LABINVEST.2011.86
P932PMC publication ID3345948
P698PubMed publication ID21691262
P5875ResearchGate publication ID51236570

P50authorAnirban MaitraQ63019787
Toby CornishQ57874316
P2093author name stringMing Zhao
Robert A Anders
Balmiki Ray
Michelle A Rudek
Amarnath Maitra
Haibo Bai
Debomoy Lahiri
Savita Bisht
Masamichi Mizuma
Mehtab A Khan
Mena Bekhit
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Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cellsQ73308051
Protective effect of curcumin in rat liver injury induced by carbon tetrachlorideQ73797820
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Multi-functional polymeric nanoparticles for tumour-targeted drug deliveryQ36409038
Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administrationQ36694655
Mouse models of liver fibrosisQ36712403
Pharmacokinetics and pharmacodynamics of curcuminQ36849531
De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activationQ36925890
Innate immune response and hepatic inflammationQ36989679
Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cellsQ37170189
Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachlorideQ37411006
Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stressQ37456073
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Mononuclear cells in liver fibrosisQ37521983
Hepatic lipocytes: the principal collagen-producing cells of normal rat liverQ37558514
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Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extractsQ37608238
Reactive oxygen and mechanisms of inflammatory liver injury: Present conceptsQ37825662
An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro.Q38311930
Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer.Q39677752
In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilitiesQ39906054
Molecular mechanisms of hepatic fibrosis and principles of therapyQ40892757
Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesisQ41055606
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophagesQ41380057
Peroxisome proliferator-activated receptors and hepatic stellate cell activationQ41758990
Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitroQ42808663
Reduced glutathione protection against rat liver microsomal injury by carbon tetrachloride. Dependence on O2Q42865606
Curcumin Enhances Oral Bioavailability and Anti-Tumor Therapeutic Efficacy of Paclitaxel upon Administration in Nanoemulsion FormulationQ42906039
Amelioration of hepatic fibrosis via Padma Hepaten is associated with altered natural killer T lymphocytesQ43297664
Synthesis of cellular fibronectin by rat liver fat-storing (Ito) cells: regulation by cytokinesQ43486795
Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growthQ44378715
The role of TGFbeta1 in initiating hepatic stellate cell activation in vivoQ44383140
Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequencesQ45236793
Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in miceQ46370419
The effects of curcumin on depressive-like behaviors in miceQ46574916
Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analoguesQ46772050
Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammationQ46897681
Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent mannersQ46939919
Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC.Q46974412
Biotransformation of curcumin through reduction and glucuronidation in miceQ48249491
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Amelioration of hepatic fibrosis via beta-glucosylceramide-mediated immune modulation is associated with altered CD8 and NKT lymphocyte distribution.Q50682895
CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice.Q52605857
P4510describes a project that usesImageJQ1659584
P433issue9
P921main subjectnanoparticleQ61231
curcuminQ312266
P304page(s)1383-1395
P577publication date2011-06-20
P1433published inLaboratory InvestigationQ6467260
P1476titleA polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation
P478volume91

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